WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Imaging at the Speed of Life
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (44)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holt, J. R.
Right arrow Articles by Eatock, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holt, J. R.
Right arrow Articles by Eatock, R. A.

 Previous Article  |  Next Article 

Volume 17, Number 22, Issue of November 15, 1997 pp. 8739-8748

Note: Due to an author's error affecting all time and frequency values, this article has been reprinted in its entirety. The corrected version can be found here.

Mechanoelectrical Transduction and Adaptation in Hair Cells of the Mouse Utricle, a Low-Frequency Vestibular Organ

Received June 27, 1997; revised Sept. 5, 1997; accepted Sept. 9, 1997.

Jeffrey R. Holt1, David P. Corey1, and Ruth Anne Eatock2

1 Department of Neurobiology, Harvard Medical School, Department of Neurology, Massachusetts General Hospital, and Howard Hughes Medical Institute, Boston, Massachusetts 02114, and 2 The Bobby R. Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030

Hair cells of inner ear organs sensitive to frequencies above 10 Hz adapt to maintained hair bundle deflections at rates that reduce their responses to lower frequencies. Mammalian vestibular organs detect head movements at frequencies well below 10 Hz. We asked whether hair cells of the mouse utricle adapt, and if so, whether the adaptation was similar to that in higher frequency organs such as the frog saccule.

Whole-cell transduction currents were recorded from hair cells in the epithelium of the mouse utricle. Hair bundles were deflected by a fluid jet or a stiff probe. The transduction currents evoked by step deflections adapted over 10-100 msec. The mean operating range was 1.5 µm (deflection of the tip of the bundle), approximately threefold larger than in frog saccule. Taller and more compact bundles of the mouse utricle account for this difference. As in frog saccular hair cells, adaptation shifted the current-deflection (I(X)) relation along the deflection axis. These adaptive shifts had time constants of 10-20 msec and reached 60-80% of stimulus amplitude. The adaptive shift and voltage-dependent bundle movement are consistent with the motor model of adaptation. When the fluid jet was used, adaptation also broadened the I(X) relation and reduced the maximum current.

Adaptation attenuated the transduction currents evoked by sinusoidal bundle deflections below 5 Hz, within the frequency range of the utricle, but because it was incomplete, substantial responses remained. Moreover, the adaptive shift mechanism preserves sensitivity even in the presence of large stimuli that would otherwise saturate transduction.

Key words: hair cell; utricle; mechanoelectrical transduction; adaptation; inner ear; vestibular




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
A. Li, J. Xue, and E. H. Peterson
Architecture of the Mouse Utricle: Macular Organization and Hair Bundle Heights
J Neurophysiol, February 1, 2008; 99(2): 718 - 733.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. A. Stauffer and J. R. Holt
Sensory Transduction and Adaptation in Inner and Outer Hair Cells of the Mouse Auditory System
J Neurophysiol, December 1, 2007; 98(6): 3360 - 3369.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. R. Holt, E. A. Stauffer, D. Abraham, and G. S. G. Geleoc
Dominant-Negative Inhibition of M-Like Potassium Conductances in Hair Cells of the Mouse Inner Ear
J. Neurosci., August 15, 2007; 27(33): 8940 - 8951.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
F. Mammano, M. Bortolozzi, S. Ortolano, and F. Anselmi
Ca2+ Signaling in the Inner Ear
Physiology, April 1, 2007; 22(2): 131 - 144.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
J.-H. Nam, J. R. Cotton, and W. Grant
A Virtual Hair Cell, I: Addition of Gating Spring Theory into a 3-D Bundle Mechanical Model
Biophys. J., March 15, 2007; 92(6): 1918 - 1928.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Jia, P. Dallos, and D. Z. Z. He
Mechanoelectric Transduction of Adult Inner Hair Cells
J. Neurosci., January 31, 2007; 27(5): 1006 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. H. Rowe and E. H. Peterson
Autocorrelation Analysis of Hair Bundle Structure in the Utricle
J Neurophysiol, November 1, 2006; 96(5): 2653 - 2669.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. McGee, R. J. Goodyear, D. R. McMillan, E. A. Stauffer, J. R. Holt, K. G. Locke, D. G. Birch, P. K. Legan, P. C. White, E. J. Walsh, et al.
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles.
J. Neurosci., June 14, 2006; 26(24): 6543 - 6553.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. M. Highstein, R. D. Rabbitt, G. R. Holstein, and R. D. Boyle
Determinants of Spatial and Temporal Coding by Semicircular Canal Afferents
J Neurophysiol, May 1, 2005; 93(5): 2359 - 2370.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. D. Rabbitt, R. Boyle, G. R. Holstein, and S. M. Highstein
Hair-Cell Versus Afferent Adaptation in the Semicircular Canals
J Neurophysiol, January 1, 2005; 93(1): 424 - 436.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. S. G. Geleoc, J. R. Risner, and J. R. Holt
Developmental Acquisition of Voltage-Dependent Conductances and Sensory Signaling in Hair Cells of the Embryonic Mouse Inner Ear
J. Neurosci., December 8, 2004; 24(49): 11148 - 11159.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Carattino, S. Sheng, and T. R. Kleyman
Epithelial Na+ Channels Are Activated by Laminar Shear Stress
J. Biol. Chem., February 6, 2004; 279(6): 4120 - 4126.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Vollrath and R. A. Eatock
Time Course and Extent of Mechanotransducer Adaptation in Mouse Utricular Hair Cells: Comparison With Frog Saccular Hair Cells
J Neurophysiol, October 1, 2003; 90(4): 2676 - 2689.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. R. Meyers, R. B. MacDonald, A. Duggan, D. Lenzi, D. G. Standaert, J. T. Corwin, and D. P. Corey
Lighting up the Senses: FM1-43 Loading of Sensory Cells through Nonselective Ion Channels
J. Neurosci., May 15, 2003; 23(10): 4054 - 4065.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Bozovic and A. J. Hudspeth
Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog
PNAS, February 4, 2003; 100(3): 958 - 963.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
O. P. Hamill and B. Martinac
Molecular Basis of Mechanotransduction in Living Cells
Physiol Rev, April 1, 2001; 81(2): 685 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. R. Holt and D. P. Corey
Two mechanisms for transducer adaptation in vertebrate hair cells
PNAS, October 24, 2000; 97(22): 11730 - 11735.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. J. Hudspeth, Y. Choe, A. D. Mehta, and P. Martin
Putting ion channels to work: Mechanoelectrical transduction, adaptation, and amplification by hair cells
PNAS, October 24, 2000; 97(22): 11765 - 11772.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. W. Y. Chen and R. A. Eatock
Major Potassium Conductance in Type I Hair Cells From Rat Semicircular Canals: Characterization and Modulation by Nitric Oxide
J Neurophysiol, July 1, 2000; 84(1): 139 - 151.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. R. Holt, D. C. Johns, S. Wang, Z.-Y. Chen, R. J. Dunn, E. Marban, and D. P. Corey
Functional Expression of Exogenous Proteins in Mammalian Sensory Hair Cells Infected With Adenoviral Vectors
J Neurophysiol, April 1, 1999; 81(4): 1881 - 1888.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Rusch, A. Lysakowski, and R. A. Eatock
Postnatal Development of Type I and Type II Hair Cells in the Mouse Utricle: Acquisition of Voltage-Gated Conductances and Differentiated Morphology
J. Neurosci., September 15, 1998; 18(18): 7487 - 7501.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-