 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
Volume 17, Number 23, Issue of December 1, 1997 pp. 9308-9314
CA3-Driven Hippocampal-Entorhinal Loop Controls Rather than Sustains In Vitro Limbic Seizures
Received July 7, 1997; revised Sept. 9, 1997; accepted Sept. 15, 1997.
Michaela Barbarosie and Massimo Avoli Research Group on Cell Biology of Excitable Tissues, Montreal Neurological Institute, Departments of Neurology and Neurosurgery, and of Physiology, McGill University, Montreal, Québec, Canada H3A 2B4
Continuous application of 4-aminopyridine (4-AP, 50 µM) to combined slices of hippocampus-entorhinal cortex obtained from adult mice induces (1) interictal discharges that initiate in the CA3 area and propagate via the hippocampal regions CA1 and subiculum to the entorhinal cortex and return to the hippocampus through the dentate gyrus; and (2) ictal discharges that originate in the entorhinal cortex and propagate via the dentate gyrus to the hippocampus proper. Ictal discharges disappear over time, whereas synchronous interictal discharges continue to occur throughout the experiment. Lesioning the Schaffer collaterals abolishes interictal discharges in CA1, entorhinal cortex, and dentate gyrus and discloses entorhinal ictal discharges that propagate, via the dentate gyrus, to the CA3 subfield. Interictal discharges originating in CA3 also prevent the occurrence of ictal events generated in the entorhinal cortex during application of Mg2+-free medium. In both models, ictal discharge generation recorded in the entorhinal cortex after Schaffer collateral cut is prevented by mimicking CA3 neuronal activity through rhythmic electrical stimulation (0.25-1.5 Hz) of the CA1 hippocampal output region. Our findings demonstrate that interictal discharges of hippocampal origin control the expression of ictal epileptiform activity in the entorhinal cortex. Sectioning the Schaffer collaterals may model the chronic epileptic condition in which cell damage in the CA3 subfield results in loss of CA3 control over the entorhinal cortex. Hence, we propose that the functional integrity of hippocampal output neurons may represent a critical control point in temporal lobe epileptogenesis.
Key words: hippocampus; entorhinal cortex; seizures; CA3; 4-aminopyridine; Mg2+-free
This article has been cited by other articles:
M. Derchansky, S. S. Jahromi, M. Mamani, D. S. Shin, A. Sik, and P. L. Carlen
Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation
J. Physiol., January 15, 2008; 586(2): 477 - 494.
[Abstract] [Full Text] [PDF]
Y. Schiller and Y. Bankirer
Cellular Mechanisms Underlying Antiepileptic Effects of Low- and High-Frequency Electrical Stimulation in Acute Epilepsy in Neocortical Brain Slices In Vitro
J Neurophysiol, March 1, 2007; 97(3): 1887 - 1902.
[Abstract] [Full Text] [PDF]
J. Ziburkus, J. R. Cressman, E. Barreto, and S. J. Schiff
Interneuron and Pyramidal Cell Interplay During In Vitro Seizure-Like Events
J Neurophysiol, June 1, 2006; 95(6): 3948 - 3954.
[Abstract] [Full Text] [PDF]
S. Jamali, F. Bartolomei, A. Robaglia-Schlupp, A. Massacrier, J.-C. Peragut, J. Regis, H. Dufour, R. Ravid, P. Roll, S. Pereira, et al.
Large-scale expression study of human mesial temporal lobe epilepsy: evidence for dysregulation of the neurotransmission and complement systems in the entorhinal cortex
Brain, March 1, 2006; 129(3): 625 - 641.
[Abstract] [Full Text] [PDF]
F Manseau, M Danik, and S Williams
A functional glutamatergic neurone network in the medial septum and diagonal band area
J. Physiol., August 1, 2005; 566(3): 865 - 884.
[Abstract] [Full Text] [PDF]
R. Benini and M. Avoli
Rat subicular networks gate hippocampal output activity in an in vitro model of limbic seizures
J. Physiol., August 1, 2005; 566(3): 885 - 900.
[Abstract] [Full Text] [PDF]
Z. Feng and D. M. Durand
Decrease in Synaptic Transmission Can Reverse the Propagation Direction of Epileptiform Activity in Hippocampus In Vivo
J Neurophysiol, March 1, 2005; 93(3): 1158 - 1164.
[Abstract] [Full Text] [PDF]
T. I. Netoff, R. Clewley, S. Arno, T. Keck, and J. A. White
Epilepsy in Small-World Networks
J. Neurosci., September 15, 2004; 24(37): 8075 - 8083.
[Abstract] [Full Text] [PDF]
M. D'Antuono, J. Louvel, R. Kohling, D. Mattia, A. Bernasconi, A. Olivier, B. Turak, A. Devaux, R. Pumain, and M. Avoli
GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex
Brain, July 1, 2004; 127(7): 1626 - 1640.
[Abstract] [Full Text] [PDF]
V. I. Dzhala and K. J. Staley
Transition from Interictal to Ictal Activity in Limbic Networks In Vitro
J. Neurosci., August 27, 2003; 23(21): 7873 - 7880.
[Abstract] [Full Text] [PDF]
R. Stoop, F. Conquet, B. Zuber, L. L. Voronin, and E. Pralong
Activation of Metabotropic Glutamate 5 and NMDA Receptors Underlies the Induction of Persistent Bursting and Associated Long-Lasting Changes in CA3 Recurrent Connections
J. Neurosci., July 2, 2003; 23(13): 5634 - 5644.
[Abstract] [Full Text] [PDF]
A. Agmon and J. E. Wells
The Role of the Hyperpolarization-Activated Cationic Current Ih in the Timing of Interictal Bursts in the Neonatal Hippocampus
J. Neurosci., May 1, 2003; 23(9): 3658 - 3668.
[Abstract] [Full Text] [PDF]
A. Rosati, Y. Aghakhani, A. Bernasconi, A. Olivier, F. Andermann, J. Gotman, and F. Dubeau
Intractable temporal lobe epilepsy with rare spikes is less severe than with frequent spikes
Neurology, April 22, 2003; 60(8): 1290 - 1295.
[Abstract] [Full Text] [PDF]
H. Khosravani, P. L. Carlen, and J. L. P. Velazquez
The Control of Seizure-Like Activity in the Rat Hippocampal Slice
Biophys. J., January 1, 2003; 84(1): 687 - 695.
[Abstract] [Full Text] [PDF]
W. H. Theodore, K. Hunter, R. Chen, F. Vega-Bermudez, B. Boroojerdi, P. Reeves-Tyer, K. Werhahn, K. R. Kelley, and L. Cohen
Transcranial magnetic stimulation for the treatment of seizures: A controlled study
Neurology, August 27, 2002; 59(4): 560 - 562.
[Abstract] [Full Text] [PDF]
T. I. Netoff and S. J. Schiff
Decreased Neuronal Synchronization during Experimental Seizures
J. Neurosci., August 15, 2002; 22(16): 7297 - 7307.
[Abstract] [Full Text] [PDF]
M. Bikson, S. C. Baraban, and D. M. Durand
Conditions Sufficient for Nonsynaptic Epileptogenesis in the CA1 Region of Hippocampal Slices
J Neurophysiol, January 1, 2002; 87(1): 62 - 71.
[Abstract] [Full Text] [PDF]
M. D'Antuono, R. Benini, G. Biagini, G. D'Arcangelo, M. Barbarosie, V. Tancredi, and M. Avoli
Limbic Network Interactions Leading to Hyperexcitability in a Model of Temporal Lobe Epilepsy
J Neurophysiol, January 1, 2002; 87(1): 634 - 639.
[Abstract] [Full Text] [PDF]
G. Sansig, T. J. Bushell, V. R. J. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini, M. Schmutz, K. Klebs, R. Shigemoto, et al.
Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7
J. Neurosci., November 15, 2001; 21(22): 8734 - 8745.
[Abstract] [Full Text] [PDF]
B. J. Gluckman, H. Nguyen, S. L. Weinstein, and S. J. Schiff
Adaptive Electric Field Control of Epileptic Seizures
J. Neurosci., January 15, 2001; 21(2): 590 - 600.
[Abstract] [Full Text] [PDF]
M. E. Calcagnotto, M. Barbarosie, and M. Avoli
Hippocampus-Entorhinal Cortex Loop and Seizure Generation in the Young Rodent Limbic System
J Neurophysiol, May 1, 2000; 83(5): 3183 - 3187.
[Abstract] [Full Text] [PDF]
M. Barbarosie, J. Louvel, I. Kurcewicz, and M. Avoli
CA3-Released Entorhinal Seizures Disclose Dentate Gyrus Epileptogenicity and Unmask a Temporoammonic Pathway
J Neurophysiol, March 1, 2000; 83(3): 1115 - 1124.
[Abstract] [Full Text] [PDF]
L. L. Thio, M. Wong, and K. A. Yamada
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission
Neurology, January 25, 2000; 54(2): 325 - 325.
[Abstract] [Full Text] [PDF]
C. Borck and J. G. R. Jefferys
Seizure-Like Events in Disinhibited Ventral Slices of Adult Rat Hippocampus
J Neurophysiol, November 1, 1999; 82(5): 2130 - 2142.
[Abstract] [Full Text] [PDF]
R. Motalli, J. Louvel, V. Tancredi, I. Kurcewicz, D. Wan-Chow-Wah, R. Pumain, and M. Avoli
GABAB Receptor Activation Promotes Seizure Activity in the Juvenile Rat Hippocampus
J Neurophysiol, August 1, 1999; 82(2): 638 - 647.
[Abstract] [Full Text] [PDF]
J. L. Weiner, T. V. Dunwiddie, and C. F. Valenzuela
Ethanol Inhibition of Synaptically Evoked Kainate Responses in Rat Hippocampal CA3 Pyramidal Neurons
Mol. Pharmacol., July 1, 1999; 56(1): 85 - 90.
[Abstract] [Full Text]
P. Golshani and E. G. Jones
Synchronized Paroxysmal Activity in the Developing Thalamocortical Network Mediated by Corticothalamic Projections and "Silent" Synapses
J. Neurosci., April 15, 1999; 19(8): 2865 - 2875.
[Abstract] [Full Text] [PDF]
P. A. Rutecki and Y. Yang
Ictal Epileptiform Activity in the CA3 Region of Hippocampal Slices Produced by Pilocarpine
J Neurophysiol, June 1, 1998; 79(6): 3019 - 3029.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|