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Volume 17, Number 24, Issue of December 15, 1997 pp. 9686-9705

Insular Cortical Projections to Functional Regions of the Striatum Correlate with Cortical Cytoarchitectonic Organization in the Primate

Received May 5, 1997; revised Sept. 10, 1997; accepted Sept. 24, 1997.

Masanori Chikama¹, Nikolaus R. McFarland², David G. Amaral³, and Suzanne N. Haber²

¹ Department of Neurological Surgery, University of Okayama Medical School, Okayama 700, Japan, ² Department of Neurobiology and Anatomy, University of Rochester School of Medicine, Rochester, New York 14642, and ³  Center for Neuroscience, University of California Davis, Davis, California 95616

We examined the striatal projections from different cytoarchitectonic regions of the insular cortex using anterograde and retrograde techniques. The shell and medial ventral striatum receive inputs primarily from the agranular and ventral dysgranular insula. The central ventral striatum receives inputs primarily from the dorsal agranular and dysgranular insula. Projections to the central ventral striatum originate from more posterior and dorsal insular regions than projections to the medial ventral striatum. The dorsolateral striatum receives projections primarily from the dorsal dysgranular and granular insula.

These results show that cytoarchitectonically less differentiated (agranular) insular regions project to the ventromedial "limbic" part of the ventral striatum, whereas more differentiated (granular) insular regions project to the dorsolateral "sensorimotor" part of the striatum. The finding that the ventral "limbic" striatum receives inputs from less differentiated regions of the insula is consistent with the general principle that less differentiated cortical regions project primarily to the "limbic" striatum. Functionally, the ventral striatum receives insular projections primarily related to integrating feeding behavior with rewards and memory, whereas the dorsolateral striatum receives insular inputs related to the somatosensation. Information regarding food acquisition in the insula may be sent to the intermediate area of the striatum.

Key words: insular cortex; orbital and medial prefrontal cortex; cingulate cortex; gustation; limbic; paralimbic; association cortex

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