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Volume 17, Number 6,
Issue of March 15, 1997
pp. 2200-2211
Copyright ©1997 Society for Neuroscience
Group I Metabotropic Glutamate Receptors mGluR1 and mGluR5a:
Localization in Both Synaptic Layers of the Rat Retina
Received Oct. 10, 1996; revised Jan. 6, 1997; accepted Jan. 9, 1997.
Peter Koulen1,
Rainer Kuhn2,
Heinz Wässle1, and
Johann Helmut Brandstätter1
1 Max-Planck-Institut für Hirnforschung,
Abteilung für Neuroanatomie, D-60528 Frankfurt am Main, Germany,
and 2 CNS Research, CIBA, CH-4002 Basel, Switzerland
We examined the distribution of the group I metabotropic glutamate
receptors, mGluR1 and mGluR5a, in the adult rat retina and during
postnatal development using receptor-specific antisera. In contrast to
the restricted localization of group II and group III mGluRs to either
the outer plexiform layer (OPL) or the inner plexiform layer (IPL),
group I mGluRs are present in both synaptic layers in the rat retina.
Double-labeling experiments and electron microscopy showed that in the
OPL the two receptors are localized on the dendritic tips of bipolar
cells postsynaptic to photoreceptor terminals. In the IPL the two
mGluRs are localized on amacrine cell processes postsynaptic to bipolar
cell terminals. These results suggest that group I mGluRs are involved
in synaptic processing in both plexiform layers and in both the
scotopic and photopic pathways in the rat retina. We propose that
mGluR1 and mGluR5a play an important modulatory role in the
responses of retinal neurons to inhibitory and excitatory
neurotransmitters.
Key words:
mGluR1;
mGluR5a;
bipolar cells;
amacrine cells;
outer
plexiform layer;
inner plexiform layer;
rat retina;
retinal
development;
immunocytochemistry
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