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Volume 17, Number 7, Issue of April 1, 1997 pp. 2469-2476
Copyright ©1997 Society for NeuroscienceNR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex
Received Nov. 18, 1996; revised Jan. 17, 1997; accepted Jan. 23, 1997.
Alexander C. Flint1, Ulrike S. Maisch2, 3, Jochen H. Weishaupt3, Arnold R. Kriegstein1, 2, and Hannah Monyer3 1 Center for Neurobiology and Behavior and 2 Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, and 3 Center for Molecular Biology, University of Heidelberg, D-69120 Heidelberg, Germany
NMDA receptors play important roles in learning and memory and in sculpting neural connections during development. After the period of peak cortical plasticity, NMDA receptor-mediated EPSCs (NMDAR EPSCs) decrease in duration. A likely mechanism for this change in NMDA receptor properties is the molecular alteration of NMDA receptor structure by regulation of NMDA receptor subunit gene expression. The four modulatory NMDAR2A-D (NR2A-D) NMDA receptor subunits are known to alter NMDA receptor properties, and the expression of these subunits is regulated developmentally. It is unclear, however, how the four NR2 subunits are expressed in individual neurons and which NR2 subunits are important to the regulation of NMDA receptor properties during development in vivo. Analysis of NR2 subunit gene expression in single characterized neurons of postnatal neocortex revealed that cells expressing NR2A subunit mRNA had faster NMDAR EPSCs than cells not expressing this subunit, regardless of postnatal age. Expression of NR2A subunit mRNA in cortical neurons at even low levels seemed sufficient to alter the NMDA receptor time course. The proportion of cells expressing NR2A and displaying fast NMDAR EPSCs increased developmentally, thus providing a molecular basis for the developmental change in mean NMDAR EPSC duration.
Key words: NMDA receptors; ion channel subunit expression; single-cell RT-PCR; dot-blot hybridization; phosphorimager analysis; patch clamp; neocortical development; neocortical physiology; synaptic transmission; EPSCs
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Bidirectional, experience-dependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development
PNAS, October 26, 1999; 96(22): 12876 - 12880.
[Abstract] [Full Text] [PDF]
G. Martin, S. H. Ahmed, T. Blank, J. Spiess, G. F. Koob, and G. R. Siggins
Chronic Morphine Treatment Alters NMDA Receptor-Mediated Synaptic Transmission in the Nucleus Accumbens
J. Neurosci., October 15, 1999; 19(20): 9081 - 9089.
[Abstract] [Full Text] [PDF]
L. L. Stark and D. J. Perkel
Two-Stage, Input-Specific Synaptic Maturation in a Nucleus Essential for Vocal Production in the Zebra Finch
J. Neurosci., October 15, 1999; 19(20): 9107 - 9116.
[Abstract] [Full Text] [PDF]
N. Chen, T. Luo, and L. A. Raymond
Subtype-Dependence of NMDA Receptor Channel Open Probability
J. Neurosci., August 15, 1999; 19(16): 6844 - 6854.
[Abstract] [Full Text] [PDF]
E. B. Roberts and A. S. Ramoa
Enhanced NR2A Subunit Expression and Decreased NMDA Receptor Decay Time at the Onset of Ocular Dominance Plasticity in the Ferret
J Neurophysiol, May 1, 1999; 81(5): 2587 - 2591.
[Abstract] [Full Text] [PDF]
F. Conti, P. Barbaresi, M. Melone, and A. Ducati
Neuronal and Glial Localization of NR1 and NR2A/B Subunits of the NMDA Receptor in the Human Cerebral Cortex
Cereb Cortex, March 1, 1999; 9(2): 110 - 120.
[Abstract] [Full Text] [PDF]
S. C. Noctor, S. L. Palmer, T. Hasling, and S. L. Juliano
Interference with the Development of Early Generated Neocortex Results in Disruption of Radial Glia and Abnormal Formation of Neocortical Layers
Cereb Cortex, March 1, 1999; 9(2): 121 - 136.
[Abstract] [Full Text] [PDF]
S. M. Logan, F. E. Rivera, and J. P. Leonard
Protein Kinase C Modulation of Recombinant NMDA Receptor Currents: Roles for the C-Terminal C1 Exon and Calcium Ions
J. Neurosci., February 1, 1999; 19(3): 974 - 986.
[Abstract] [Full Text] [PDF]
E. Morikawa, H. Mori, Y. Kiyama, M. Mishina, T. Asano, and T. Kirino
Attenuation of Focal Ischemic Brain Injury in Mice Deficient in the epsilon 1 (NR2A) Subunit of NMDA Receptor
J. Neurosci., December 1, 1998; 18(23): 9727 - 9732.
[Abstract] [Full Text] [PDF]
J. H. Singer, E. M. Talley, D. A. Bayliss, and A. J. Berger
Development of Glycinergic Synaptic Transmission to Rat Brain Stem Motoneurons
J Neurophysiol, November 1, 1998; 80(5): 2608 - 2620.
[Abstract] [Full Text] [PDF]
M. C Bellingham, R. Lim, and B. Walmsley
Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in rat
J. Physiol., September 15, 1998; 511(3): 861 - 869.
[Abstract] [Full Text] [PDF]
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