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Previous Article | Next Article
The Journal of Neuroscience, January 1, 1998, 18(1):26-35
Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence
Christopher S. Wallace1, Gregory L. Lyford2, Paul F. Worley2, 3, and Oswald Steward1 1 Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, and Departments of 2 Neuroscience and 3 Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205
This study characterizes the differential targeting of recently synthesized immediate early gene (IEG) mRNAs to neuronal cell bodies versus dendrites and tests the hypothesis that this targeting is based on signals in the encoded proteins. A single electroconvulsive seizure induces the expression of a number of IEG mRNAs in granule cells of the dentate gyrus. Most of these IEG mRNAs remain in the cell body, including two that are characterized in the present study (the mRNAs for NGFI-A and COX-2). In contrast, the mRNA for Arc moved rapidly into dendrites at an apparent rate of ~300 µm/hr. Inhibiting protein synthesis with cycloheximide did not disrupt the differential mRNA sorting, demonstrating that the differential targeting of mRNAs is not dependent on translation.
Key words: Arc; dendritic mRNA; mRNA localization; electroconvulsive seizure; mRNA transport; immediate early gene; dendrite
Copyright © 1998 Society for Neuroscience 0270-6474/98/18126-10$05.00/0
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