QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (30) Citing Articles via Google Scholar Google Scholar Articles by McNay, E. C. Articles by Gold, P. E. Search for Related Content PubMed PubMed Citation Articles by McNay, E. C. Articles by Gold, P. E.

 Previous Article  |  Next Article 

The Journal of Neuroscience, May 15, 1998, 18(10):3853-3858

Memory Modulation Across Neural Systems: Intra-Amygdala Glucose Reverses Deficits Caused by Intraseptal Morphine on a Spatial Task But Not on an Aversive Task

Ewan C. McNay and Paul E. Gold

Neuroscience Program and Department of Psychology, University of Virginia, Charlottesville, Virginia 22903

Based largely on dissociations of the effects of different lesions on learning and memory, memories for different attributes appear to be organized in independent neural systems. Results obtained with direct injections of drugs into one brain region at a time support a similar conclusion. The present experiments investigated the effects of simultaneous pharmacological manipulation of two neural systems, the amygdala and the septohippocampal system, to examine possible interactions of memory modulation across systems. Morphine injected into the medial septum impaired memory both for avoidance training and during spontaneous alternation. When glucose was concomitantly administered to the amygdala, glucose reversed the morphine-induced deficits in memory during alternation but not for avoidance training. These results suggest that the amygdala is involved in modulation of spatial memory processes and that direct injections of memory-modulating drugs into the amygdala do not always modulate memory for aversive events. These findings are contrary to predictions from the findings of lesion studies and of studies using direct injections of drugs into single brain areas. Thus, the independence of neural systems responsible for processing different classes of memory is less clear than implied by studies using lesions or injections of drugs into single brain areas.

Key words: glucose; memory; neural systems; medial septum; amygdala; morphine; spontaneous alternation; inhibitory avoidance

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/18103853-06$05.00/0

This article has been cited by other articles:

				E. C. McNay, A. Williamson, R. J. McCrimmon, and R. S. Sherwin Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia. Diabetes, April 1, 2006; 55(4): 1088 - 1095. [Abstract] [Full Text] [PDF]

				C. E. Canal, S. J. Stutz, and P. E. Gold Glucose injections into the dorsal hippocampus or dorsolateral striatum of rats prior to T-maze training: Modulation of learning rates and strategy selection Learn. Mem., July 1, 2005; 12(4): 367 - 374. [Abstract] [Full Text] [PDF]

				E. C. McNay and P. E. Gold Food for thought: fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulation. Behav Cogn Neurosci Rev, December 1, 2002; 1(4): 264 - 280. [Abstract] [PDF]

				E. C. McNay and P. E. Gold Age-Related Differences in Hippocampal Extracellular Fluid Glucose Concentration During Behavioral Testing and Following Systemic Glucose Administration J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2001; 56(2): 66B - 71. [Abstract] [Full Text]

				E. C. McNay, T. M. Fries, and P. E. Gold Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task PNAS, March 14, 2000; 97(6): 2881 - 2885. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help