 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, July 15, 1998, 18(14):5203-5211
Neuronal Matrix Metalloproteinase-2 Degrades and Inactivates a Neurite-Inhibiting Chondroitin Sulfate Proteoglycan
Jian Zuo1, Toby A. Ferguson1, Yosbani J. Hernandez1, William G. Stetler-Stevenson2, and David Muir1 1 Departments of Pediatrics (Neurology Division) and Neuroscience, University of Florida Brain Institute and College of Medicine, Gainesville, Florida 32610-0296, and 2 Extracellular Matrix Pathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
Chondroitin sulfate proteoglycans (CSPGs) are implicated in the regulation of axonal growth. We previously reported that the neurite-promoting activity of laminin is inhibited by association with a Schwann cell-derived CSPG and that endoneurial laminin may be inhibited by this CSPG as well [Zuo J, Hernandez YJ, Muir D (1998) Chondroitin sulfate proteoglycan with neurite-inhibiting activity is upregulated after peripheral nerve injury. J Neurobiol 34:41-54]. Mechanisms regulating axonal growth were studied by using an in vitro bioassay in which regenerating embryonic dorsal root ganglionic neurons (DRGn) were grown on sections of normal adult nerve. DRGn achieved slow neuritic growth on sections of normal nerve, which was reduced significantly by treatment with metalloproteinase inhibitors. Similar results were obtained on a synthetic substratum composed of laminin and inhibitory CSPG. DRGn expressed the matrix metalloproteinase, MMP-2, which was transported to the growth cone. Recombinant MMP-2 inactivated the neurite-inhibiting CSPG without hindering the neurite-promoting potential of laminin. Similarly, neuritic growth by DRGn cultured on normal nerve sections was increased markedly by first treating the nerve sections with MMP-2. The proteolytic deinhibition by MMP-2 was equivalent to and nonadditive with that achieved by chondroitinase, suggesting that both enzymes inactivated inhibitory CSPG. Additionally, the increases in neuritic growth resulting from treating nerve sections with MMP-2 or chondroitinase were blocked by anti-laminin antibodies. From these results we conclude that MMP-2 provides a mechanism for the deinhibition of laminin in the endoneurial basal lamina and may play an important role in the regeneration of peripheral nerve.
Key words: chondroitin sulfate proteoglycan; matrix metalloproteinase; neuronal regeneration; neurite inhibitor; basal lamina; peripheral nerve; laminin; cryoculture
Copyright © 1998 Society for Neuroscience 0270-6474/98/18145203-09$05.00/0
This article has been cited by other articles:
C. M. Miller, A. Page-McCaw, and H. T. Broihier
Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo
Development, January 1, 2008; 135(1): 95 - 109.
[Abstract] [Full Text] [PDF]
B Gonthier, C Nasarre, L Roth, M Perraut, N Thomasset, G Roussel, D Aunis, and D Bagnard
Functional Interaction between Matrix Metalloproteinase-3 and Semaphorin-3C during Cortical Axonal Growth and Guidance
Cereb Cortex, July 1, 2007; 17(7): 1712 - 1721.
[Abstract] [Full Text] [PDF]
Y. Zhang, H. J. Klassen, B. A. Tucker, M.-T. R. Perez, and M. J. Young
CNS Progenitor Cells Promote a Permissive Environment for Neurite Outgrowth via a Matrix Metalloproteinase-2-Dependent Mechanism
J. Neurosci., April 25, 2007; 27(17): 4499 - 4506.
[Abstract] [Full Text] [PDF]
T. Suzuki, M. Mandai, M. Akimoto, N. Yoshimura, and M. Takahashi
The Simultaneous Treatment of MMP-2 Stimulants in Retinal Transplantation Enhances Grafted Cell Migration into the Host Retina
Stem Cells, November 1, 2006; 24(11): 2406 - 2411.
[Abstract] [Full Text] [PDF]
J.-Y. C. Hsu, R. McKeon, S. Goussev, Z. Werb, J.-U. Lee, A. Trivedi, and L. J. Noble-Haeusslein
Matrix Metalloproteinase-2 Facilitates Wound Healing Events That Promote Functional Recovery after Spinal Cord Injury
J. Neurosci., September 27, 2006; 26(39): 9841 - 9850.
[Abstract] [Full Text] [PDF]
E. Pastrana, M. T. Moreno-Flores, E. N. Gurzov, J. Avila, F. Wandosell, and J. Diaz-Nido
Genes associated with adult axon regeneration promoted by olfactory ensheathing cells: a new role for matrix metalloproteinase 2.
J. Neurosci., May 17, 2006; 26(20): 5347 - 5359.
[Abstract] [Full Text] [PDF]
F. Mannello, G. A.M. Tonti, G. P. Bagnara, and S. Papa
Role and Function of Matrix Metalloproteinases in the Differentiation and Biological Characterization of Mesenchymal Stem Cells
Stem Cells, March 1, 2006; 24(3): 475 - 481.
[Abstract] [Full Text] [PDF]
S. Hall
The response to injury in the peripheral nervous system
J Bone Joint Surg Br, October 1, 2005; 87-B(10): 1309 - 1319.
[Full Text] [PDF]
C. L. Hehr, J. C. Hocking, and S. McFarlane
Matrix metalloproteinases are required for retinal ganglion cell axon guidance at select decision points
Development, August 1, 2005; 132(15): 3371 - 3379.
[Abstract] [Full Text] [PDF]
V. J. Tom, C. M. Doller, A. T. Malouf, and J. Silver
Astrocyte-Associated Fibronectin Is Critical for Axonal Regeneration in Adult White Matter
J. Neurosci., October 20, 2004; 24(42): 9282 - 9290.
[Abstract] [Full Text] [PDF]
P. H. Larsen and V. W. Yong
The Expression of Matrix Metalloproteinase-12 by Oligodendrocytes Regulates Their Maturation and Morphological Differentiation
J. Neurosci., September 1, 2004; 24(35): 7597 - 7603.
[Abstract] [Full Text] [PDF]
P. H. Larsen, J. E. Wells, W. B. Stallcup, G. Opdenakker, and V. W. Yong
Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan
J. Neurosci., December 3, 2003; 23(35): 11127 - 11135.
[Abstract] [Full Text] [PDF]
C. A. Krekoski, D. Neubauer, J. B. Graham, and D. Muir
Metalloproteinase-Dependent Predegeneration In Vitro Enhances Axonal Regeneration within Acellular Peripheral Nerve Grafts
J. Neurosci., December 1, 2002; 22(23): 10408 - 10415.
[Abstract] [Full Text] [PDF]
C. A. Webber, J. C. Hocking, V. W. Yong, C. L. Stange, and S. McFarlane
Metalloproteases and Guidance of Retinal Axons in the Developing Visual System
J. Neurosci., September 15, 2002; 22(18): 8091 - 8100.
[Abstract] [Full Text] [PDF]
E. Llano, G. Adam, A. M. Pendas, V. Quesada, L. M. Sanchez, I. Santamaria, S. Noselli, and C. Lopez-Otin
Structural and Enzymatic Characterization of Drosophila Dm2-MMP, a Membrane-bound Matrix Metalloproteinase with Tissue-specific Expression
J. Biol. Chem., June 21, 2002; 277(26): 23321 - 23329.
[Abstract] [Full Text] [PDF]
A. Szklarczyk, J. Lapinska, M. Rylski, R. D. G. McKay, and L. Kaczmarek
Matrix Metalloproteinase-9 Undergoes Expression and Activation during Dendritic Remodeling in Adult Hippocampus
J. Neurosci., February 1, 2002; 22(3): 920 - 930.
[Abstract] [Full Text] [PDF]
H. Hayashita-Kinoh, H. Kinoh, A. Okada, K. Komori, Y. Itoh, T. Chiba, M. Kajita, I. Yana, and M. Seiki
Membrane-Type 5 Matrix Metalloproteinase Is Expressed in Differentiated Neurons and Regulates Axonal Growth
Cell Growth Differ., November 1, 2001; 12(11): 573 - 580.
[Abstract] [Full Text] [PDF]
C. A. Krekoski, D. Neubauer, J. Zuo, and D. Muir
Axonal Regeneration into Acellular Nerve Grafts Is Enhanced by Degradation of Chondroitin Sulfate Proteoglycan
J. Neurosci., August 15, 2001; 21(16): 6206 - 6213.
[Abstract] [Full Text] [PDF]
M. L. Condic
Adult Neuronal Regeneration Induced by Transgenic Integrin Expression
J. Neurosci., July 1, 2001; 21(13): 4782 - 4788.
[Abstract] [Full Text] [PDF]
L. B. Siconolfi and N. W. Seeds
Induction of the Plasminogen Activator System Accompanies Peripheral Nerve Regeneration after Sciatic Nerve Crush
J. Neurosci., June 15, 2001; 21(12): 4336 - 4347.
[Abstract] [Full Text] [PDF]
M. S. Ramer, I. Duraisingam, J. V. Priestley, and S. B. McMahon
Two-Tiered Inhibition of Axon Regeneration at the Dorsal Root Entry Zone
J. Neurosci., April 15, 2001; 21(8): 2651 - 2660.
[Abstract] [Full Text] [PDF]
X. Wang, J. Jung, M. Asahi, W. Chwang, L. Russo, M. A. Moskowitz, C. E. Dixon, M. E. Fini, and E. H. Lo
Effects of Matrix Metalloproteinase-9 Gene Knock-Out on Morphological and Motor Outcomes after Traumatic Brain Injury
J. Neurosci., September 15, 2000; 20(18): 7037 - 7042.
[Abstract] [Full Text] [PDF]
J. Jaworski, I. W. Biedermann, J. Lapinska, A. Szklarczyk, I. Figiel, D. Konopka, D. Nowicka, R. K. Filipkowski, M. Hetman, A. Kowalczyk, et al.
Neuronal Excitation-driven and AP-1-dependent Activation of Tissue Inhibitor of Metalloproteinases-1 Gene Expression in Rodent Hippocampus
J. Biol. Chem., October 1, 1999; 274(40): 28106 - 28112.
[Abstract] [Full Text] [PDF]
L. Y. S. Oh, P. H. Larsen, C. A. Krekoski, D. R. Edwards, F. Donovan, Z. Werb, and V. W. Yong
Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes
J. Neurosci., October 1, 1999; 19(19): 8464 - 8475.
[Abstract] [Full Text] [PDF]
H. Nagase and J. F. Woessner Jr.
Matrix Metalloproteinases
J. Biol. Chem., July 30, 1999; 274(31): 21491 - 21494.
[Full Text] [PDF]
S. J. Price, D. R. Greaves, and H. Watkins
Identification of Novel, Functional Genetic Variants in the Human Matrix Metalloproteinase-2 Gene. ROLE OF Sp1 IN ALLELE-SPECIFIC TRANSCRIPTIONAL REGULATION
J. Biol. Chem., March 2, 2001; 276(10): 7549 - 7558.
[Abstract] [Full Text] [PDF]
S. Kiryu-Seo, M. Sasaki, H. Yokohama, S. Nakagomi, T. Hirayama, S. Aoki, K. Wada, and H. Kiyama
Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers
PNAS, April 11, 2000; 97(8): 4345 - 4350.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|