WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (72)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheng, C. M.
Right arrow Articles by Bondy, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheng, C. M.
Right arrow Articles by Bondy, C. A.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 1998, 18(15):5673-5681

Biochemical and Morphometric Analyses Show that Myelination in the Insulin-like Growth Factor 1 Null Brain Is Proportionate to Its Neuronal Composition

Clara M. Cheng1, George Joncas1, Rickey R. Reinhardt1, Robert Farrer2, Richard Quarles2, Jeremy Janssen1, Michael P. McDonald3, Jacqueline N. Crawley3, Lynn Powell-Braxton4, and Carolyn A. Bondy1

1 Developmental Endocrinology Branch, National Institute of Child Health and Human Development, 2 Myelin and Brain Development Section, Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Diseases and Stroke, 3 Section on Behavioral Neuropharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, and 4 Department of Cardiovascular Research, Genentech, San Francisco, California 94080

To elucidate the role of insulin-like growth factor 1 (IGF1) in the normal development of brain myelination, we used behavioral, biochemical, and histological analyses to compare the myelination of brains from Igf1-/- and wild-type (WT) littermate mice. The studies were conducted at postnatal day 40, at which time the Igf1-/- mice weighed ~66% less than wild-type mice. However, the Igf1-/- brain weight was only reduced by ~34%. Formal neurological testing showed no sign of central or peripheral myelinopathy in Igf1-/- mice. Myelin composition was not significantly different, and myelin concentration, normalized to brain weight or protein, was equal in Igf1-/- and WT mice. Likewise, concentrations of myelin-specific proteins (MBP, myelin proteolipid protein, MAG, and 2',3'-cyclic nucleotide,3'-phosphodiesterase) were not significantly different in Igf1-/- and WT mice. The myelin-associated lipids galactocerebroside and sulfatide were modestly reduced in Igf1-/- brains. Regional oligodendrocyte populations and myelin staining patterns were comparable in Igf1-/- and WT brains, with the notable exception of the olfactory system. The Igf1-/- olfactory bulb was profoundly reduced in size and was depleted of mitral neurons and oligodendrocytes, and its efferent tracts were depleted of myelin.

In summary, this study shows that myelination of the Igf1-/- brain is proportionate to its neuronal composition. Where projection neurons are preserved despite the deletion of IGF1, as in the cerebellar system, oligodendrocytes and myelination are indistinguishable from wild type. Where projection neurons are depleted, as in the olfactory bulb, oligodendrocytes are also depleted, and myelination is reduced in proportion to the reduced projection neuron mass. These data make a strong case for the primacy of axonal factors, not including IGF1, in determining oligodendrocyte survival and myelination.

Key words: IGF1; oligodendrocyte; olfactory bulb; myelin basic protein (MBP); myelin proteolipid protein (PLP); 2',3'-cyclic nucleotide, 3'-phosphodiesterase (CNPase); myelin-associated glycoprotein (MAG)

Copyright © 1998 Society for Neuroscience  0270-6474/98/18155673-09$05.00/0


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
G. Mairet-Coello, A. Tury, and E. DiCicco-Bloom
Insulin-Like Growth Factor-1 Promotes G1/S Cell Cycle Progression through Bidirectional Regulation of Cyclins and Cyclin-Dependent Kinase Inhibitors via the Phosphatidylinositol 3-Kinase/Akt Pathway in Developing Rat Cerebral Cortex
J. Neurosci., January 21, 2009; 29(3): 775 - 788.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Joseph D'Ercole and P. Ye
Expanding the Mind: Insulin-Like Growth Factor I and Brain Development
Endocrinology, December 1, 2008; 149(12): 5958 - 5962.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Romanelli, A. P. LeBeau, C. G. Fulmer, D. A. Lazzarino, A. Hochberg, and T. L. Wood
Insulin-like Growth Factor Type-I Receptor Internalization and Recycling Mediate the Sustained Phosphorylation of Akt
J. Biol. Chem., August 3, 2007; 282(31): 22513 - 22524.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
V. C. Russo, P. D. Gluckman, E. L. Feldman, and G. A. Werther
The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain
Endocr. Rev., December 1, 2005; 26(7): 916 - 943.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. M. Cheng, V. Tseng, J. Wang, D. Wang, L. Matyakhina, and C. A. Bondy
Tau Is Hyperphosphorylated in the Insulin-Like Growth Factor-I Null Brain
Endocrinology, December 1, 2005; 146(12): 5086 - 5091.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O. Tschopp, Z.-Z. Yang, D. Brodbeck, B. A. Dummler, M. Hemmings-Mieszczak, T. Watanabe, T. Michaelis, J. Frahm, and B. A. Hemmings
Essential role of protein kinase B{gamma} (PKB{gamma}/Akt3) in postnatal brain development but not in glucose homeostasis
Development, July 1, 2005; 132(13): 2943 - 2954.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. M. Easton, H. Cho, K. Roovers, D. W. Shineman, M. Mizrahi, M. S. Forman, V. M.-Y. Lee, M. Szabolcs, R. de Jong, T. Oltersdorf, et al.
Role for Akt3/Protein Kinase B{gamma} in Attainment of Normal Brain Size
Mol. Cell. Biol., March 1, 2005; 25(5): 1869 - 1878.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. L. Mason, S. Xuan, I. Dragatsis, A. Efstratiadis, and J. E. Goldman
Insulin-Like Growth Factor (IGF) Signaling through Type 1 IGF Receptor Plays an Important Role in Remyelination
J. Neurosci., August 20, 2003; 23(20): 7710 - 7718.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Vicario-Abejon, M. J. Yusta-Boyo, C. Fernandez-Moreno, and F. de Pablo
Locally Born Olfactory Bulb Stem Cells Proliferate in Response to Insulin-Related Factors and Require Endogenous Insulin-Like Growth Factor-I for Differentiation into Neurons and Glia
J. Neurosci., February 1, 2003; 23(3): 895 - 906.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Ye, L. Li, R. G. Richards, R. P. DiAugustine, and A. J. D'Ercole
Myelination Is Altered in Insulin-Like Growth Factor-I Null Mutant Mice
J. Neurosci., July 15, 2002; 22(14): 6041 - 6051.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Camarero, C. Avendano, C. Fernandez-Moreno, A. Villar, J. Contreras, F. de Pablo, J. G. Pichel, and I. Varela-Nieto
Delayed Inner Ear Maturation and Neuronal Loss in Postnatal Igf-1-Deficient Mice
J. Neurosci., October 1, 2001; 21(19): 7630 - 7641.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Pencea, K. D. Bingaman, S. J. Wiegand, and M. B. Luskin
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus
J. Neurosci., September 1, 2001; 21(17): 6706 - 6717.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. M. CHENG, M. COHEN, J. WANG, and C. A. BONDY
Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex
FASEB J, April 1, 2001; 15(6): 907 - 915.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. M. Cheng, R. R. Reinhardt, W.-H. Lee, G. Joncas, S. C. Patel, and C. A. Bondy
Insulin-like growth factor 1 regulates developing brain glucose metabolism
PNAS, August 17, 2000; (2000) 170008497.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
M. M. Niblock, J. K. Brunso-Bechtold, and D. R. Riddle
Insulin-Like Growth Factor I Stimulates Dendritic Growth in Primary Somatosensory Cortex
J. Neurosci., June 1, 2000; 20(11): 4165 - 4176.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. I. Aberg, N. D. Aberg, H. Hedbacker, J. Oscarsson, and P. S. Eriksson
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
J. Neurosci., April 15, 2000; 20(8): 2896 - 2903.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. WANG, J. ZHOU, and C. A. BONDY
Igf1 promotes longitudinal bone growth by insulin-like actions augmenting chondrocyte hypertrophy
FASEB J, November 1, 1999; 13(14): 1985 - 1990.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. M. Cheng, R. R. Reinhardt, W.-H. Lee, G. Joncas, S. C. Patel, and C. A. Bondy
Insulin-like growth factor 1 regulates developing brain glucose metabolism
PNAS, August 29, 2000; 97(18): 10236 - 10241.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-