 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, September 1, 1998, 18(17):6650-6661
Inwardly Rectifying Potassium (IRK) Currents Are Correlated with IRK Subunit Expression in Rat Nucleus Accumbens Medium Spiny Neurons
Paul G. Mermelstein, Wen-Jie Song, Tatiana Tkatch, Zhen Yan, and D. James Surmeier Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis Tennessee 38163
Inwardly rectifying K+ (IRK) channels are critical for shaping cell excitability. Whole-cell patch-clamp and single-cell RT-PCR techniques were used to characterize the inwardly rectifying K+ currents found in projection neurons of the rat nucleus accumbens. Inwardly rectifying currents were highly selective for K+ and blocked by low millimolar concentrations of Cs+ or Ba2+. In a subset of neurons, the inwardly rectifying current appeared to inactivate at hyperpolarized membrane potentials. In an attempt to identify this subset, neurons were profiled using single-cell RT-PCR. Neurons expressing substance P mRNA exhibited noninactivating inward rectifier currents, whereas neurons expressing enkephalin mRNA exhibited inactivating inward rectifier currents. The inactivation of the inward rectifier was correlated with the expression of IRK1 mRNA. These results demonstrate a clear physiological difference in the properties of medium spiny neurons and suggest that this difference could influence active state transitions driven by cortical and hippocampal excitatory input.
Key words: ventral striatum; medium spiny neurons; single-cell RT-PCR; voltage clamp; potassium channels; inward rectifier; enkephalin; substance P
Copyright © 1998 Society for Neuroscience 0270-6474/98/18176650-12$05.00/0
This article has been cited by other articles:
A. R. A. Rodrigues and D. Oertel
Hyperpolarization-Activated Currents Regulate Excitability in Stellate Cells of the Mammalian Ventral Cochlear Nucleus
J Neurophysiol, January 1, 2006; 95(1): 76 - 87.
[Abstract] [Full Text] [PDF]
J. A. Wolf, J. T. Moyer, M. T. Lazarewicz, D. Contreras, M. Benoit-Marand, P. O'Donnell, and L. H. Finkel
NMDA/AMPA Ratio Impacts State Transitions and Entrainment to Oscillations in a Computational Model of the Nucleus Accumbens Medium Spiny Projection Neuron
J. Neurosci., October 5, 2005; 25(40): 9080 - 9095.
[Abstract] [Full Text] [PDF]
N. Gu, K. Vervaeke, H. Hu, and J. F Storm
Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells
J. Physiol., August 1, 2005; 566(3): 689 - 715.
[Abstract] [Full Text] [PDF]
M. A. Ariano, C. Cepeda, C. R. Calvert, J. Flores-Hernandez, E. Hernandez-Echeagaray, G. J. Klapstein, S. H. Chandler, N. Aronin, M. DiFiglia, and M. S. Levine
Striatal Potassium Channel Dysfunction in Huntington's Disease Transgenic Mice
J Neurophysiol, May 1, 2005; 93(5): 2565 - 2574.
[Abstract] [Full Text] [PDF]
Y. Dong, D. Cooper, F. Nasif, X.-T. Hu, and F. J. White
Dopamine Modulates Inwardly Rectifying Potassium Currents in Medial Prefrontal Cortex Pyramidal Neurons
J. Neurosci., March 24, 2004; 24(12): 3077 - 3085.
[Abstract] [Full Text] [PDF]
W. Shen, S. Hernandez-Lopez, T. Tkatch, J. E. Held, and D. J. Surmeier
Kv1.2-Containing K+ Channels Regulate Subthreshold Excitability of Striatal Medium Spiny Neurons
J Neurophysiol, March 1, 2004; 91(3): 1337 - 1349.
[Abstract] [Full Text] [PDF]
R Vergara, C Rick, S Hernandez-Lopez, J A Laville, J N Guzman, E Galarraga, D J Surmeier, and J Bargas
Spontaneous voltage oscillations in striatal projection neurons in a rat corticostriatal slice
J. Physiol., November 15, 2003; 553(1): 169 - 182.
[Abstract] [Full Text] [PDF]
J. N. Guzman, A. Hernandez, E. Galarraga, D. Tapia, A. Laville, R. Vergara, J. Aceves, and J. Bargas
Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum
J. Neurosci., October 1, 2003; 23(26): 8931 - 8940.
[Abstract] [Full Text] [PDF]
A. J. Gruber, S. A. Solla, D. J. Surmeier, and J. C. Houk
Modulation of Striatal Single Units by Expected Reward: A Spiny Neuron Model Displaying Dopamine-Induced Bistability
J Neurophysiol, August 1, 2003; 90(2): 1095 - 1114.
[Abstract] [Full Text] [PDF]
S. Yasumoto, E. Tanaka, G. Hattori, H. Maeda, and H. Higashi
Direct and Indirect Actions of Dopamine on the Membrane Potential in Medium Spiny Neurons of the Mouse Neostriatum
J Neurophysiol, March 1, 2002; 87(3): 1234 - 1243.
[Abstract] [Full Text] [PDF]
A. E. Stewart and R. C. Foehring
Effects of Spike Parameters and Neuromodulators on Action Potential Waveform-Induced Calcium Entry Into Pyramidal Neurons
J Neurophysiol, April 1, 2001; 85(4): 1412 - 1423.
[Abstract] [Full Text] [PDF]
M. Roudbaraki, A. Lorsignol, L. Langouche, G. Callewaert, H. Vankelecom, and C. Denef
Target Cells of {gamma}3-Melanocyte-Stimulating Hormone Detected through Intracellular Ca2+ Responses in Immature Rat Pituitary Constitute a Fraction of All Main Pituitary Cell Types, but Mostly Express Multiple Hormone Phenotypes at the Messenger Ribonucleic Acid Level. Refractoriness to Melanocortin-3 Receptor Blockade in the Lacto-Somatotroph Lineage
Endocrinology, October 1, 1999; 140(10): 4874 - 4885.
[Abstract] [Full Text]
R. Wessel, W. B. Kristan Jr, and D. Kleinfeld
Supralinear Summation of Synaptic Inputs by an Invertebrate Neuron: Dendritic Gain Is Mediated by an "Inward Rectifier" K+ Current
J. Neurosci., July 15, 1999; 19(14): 5875 - 5888.
[Abstract] [Full Text] [PDF]
E. Galarraga, S. Hernandez-Lopez, A. Reyes, I. Miranda, F. Bermudez-Rattoni, C. Vilchis, and J. Bargas
Cholinergic Modulation of Neostriatal Output: A Functional Antagonism between Different Types of Muscarinic Receptors
J. Neurosci., May 1, 1999; 19(9): 3629 - 3638.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|