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 Previous Article
The Journal of Neuroscience, September 1, 1998, 18(17):7040-7046
Neurotrophin 4 Is Required for the Survival of a Subclass of Hair
Follicle Receptors
Cheryl L.
Stucky1,
Thomas
DeChiara2,
Ronald M.
Lindsay2,
George D.
Yancopoulos2, and
Martin
Koltzenburg1
1 Department of Neurology, University of
Würzburg, D-97080 Würzburg, Germany, and
2 Regeneron Pharmaceuticals, Tarrytown, New York
10591
Neurotrophin-4 (NT4) is the most recently discovered neurotrophic
factor in mammals and, functionally, the least well understood. Here,
we used mice that lack NT4 to determine whether NT4 is required for the
survival of functionally identified subclasses of cutaneous sensory
neurons. By using three independent methods of histological and
electrophysiological analysis, we show that NT4 is specifically required for the survival of down hair (D-hair) receptors that innervate a subpopulation of hair follicles. All other functionally distinct types of afferents neurons innervating hairy skin were not
affected in their survival or in their function. Previous studies have
shown that BDNF is required for the mechanical sensitivity of slowly
adapting (SA) mechanoreceptors but not for the postnatal survival of
myelinated cutaneous afferent fibers. In contrast, the receptive
properties of SA mechanoreceptors were not impaired in animals lacking
NT4. Consequently, these data show that the two trkB ligands, NT4 and
BDNF, have distinct and nonoverlapping roles in supporting cutaneous
sensory neurons. Whereas NT4 is required for the survival of D-hair
receptors, BDNF supports the mechanical function of SA fibers.
Key words:
Key Words: NT4; brain-derived neurotrophin factor; NT3 (neurotrophin
3) wild-type mice; D-hair; skin innervation
Copyright © 1998 Society for Neuroscience 0270-6474/98/18177040-07$05.00/0
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