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Previous Article | Next Article
The Journal of Neuroscience, September 15, 1998, 18(18):7178-7188
Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity
Tatsuya Ingi1, Andrejs M. Krumins3, Peter Chidiac3, Greg M. Brothers4, Stephen Chung4, Bryan E. Snow4, Carol A. Barnes5, Anthony A. Lanahan1, David P. Siderovski4, Elliott M. Ross3, Alfred G. Gilman3, and Paul F. Worley1, 2 Departments of 1 Neuroscience and 2 Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21210, 3 Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, 4 Quantitative Biology Laboratory, Amgen Institute, Toronto, Ontario M5G 2C1, Canada, and 5 Department of Psychology and Neurology and Division of Neuronal Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 84724
Long-term neuronal plasticity is known to be dependent on rapid de novo synthesis of mRNA and protein, and recent studies provide insight into the molecules involved in this response. Here, we demonstrate that mRNA encoding a member of the regulator of G-protein signaling (RGS) family, RGS2, is rapidly induced in neurons of the hippocampus, cortex, and striatum in response to stimuli that evoke plasticity. Although several members of the RGS family are expressed in brain with discrete neuronal localizations, RGS2 appears unique in that its expression is dynamically responsive to neuronal activity. In biochemical assays, RGS2 stimulates the GTPase activity of the
subunit of Gq and Gi1. The effect on Gi1 was observed only after reconstitution of the protein in phospholipid vesicles containing M2 muscarinic acetylcholine receptors. RGS2 also inhibits both Gq- and Gi-dependent responses in transfected cells. These studies suggest a novel mechanism linking neuronal activity and signal transduction.
Key words: RGS; immediate early genes; seizure; neuronal plasticity; G-protein; GTPase-activating proteins; MAP kinase
Copyright © 1998 Society for Neuroscience 0270-6474/98/18187178-11$05.00/0
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