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The Journal of Neuroscience, October 1, 1998, 18(19):8086-8094

Ascending Projections of Simple and Complex Cells in Layer 6 of the Cat Striate Cortex

Judith A. Hirsch, Christine A. Gallagher, José-Manuel Alonso, and Luis M. Martinez

Laboratory of Neurobiology, The Rockefeller University, New York, New York 10021

Receptive field properties vary systematically across the different layers of the cat striate cortex. Understanding how these functional differences emerge requires a precise description of the interlaminar connections and the quality of information that they transmit. This study examines the contribution of the two physiological types of neuron in layer 6, simple and complex, to the cortical microcircuit. The approach was to make whole-cell recordings with dye-filled electrodes in vivo to correlate visual response property with intracortical projection pattern. The two simple cells we stained projected to layer 4, as previously reported (; ). Six of the eight complex cells that we labeled projected to the superficial layers, a pathway not previously described in the cat. The remaining two cells targeted the infragranular layers. Layer 4 is dominated by simple cells, whereas layers 5 and 2+3 are mainly composed of complex cells (; ). Hence, our results indicate that the ascending projections of simple cells in layer 6 target other simple cells. In parallel, the ascending projections of a population of complex cells in layer 6 favor other complex cells. Anatomical experiments in several species (; ; ; ) had also demonstrated that layer 6 gives rise to two separate intracortical pathways. Pooling the results of these anatomical studies with our own suggests a common feature of the laminar organization: cells that project to different intracortical targets have distinct functional characteristics.

Key words: visual cortex; patch recording in vivo; simple cell; complex cell; layer 6; pyramidal cell

Copyright © 1998 Society for Neuroscience  0270-6474/98/18198086-09$05.00/0


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