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The Journal of Neuroscience, October 15, 1998, 18(20):8539-8549
Synaptic Regulation of Action Potential Timing in Neostriatal
Cholinergic Interneurons
Ben D.
Bennett and
Charles J.
Wilson
Department of Anatomy and Neurobiology, University of Tennessee,
Memphis, Tennessee 38163
Action potentials in neostriatal cholinergic interneurons recorded
in vivo are triggered by summation of two or three
discrete synaptic depolarizations (). The ability
and precision with which EPSPs and IPSPs regulate action potential timing was therefore investigated in vitro. Cholinergic
interneurons were identified on the basis of morphological and
electrophysiological characteristics in neostriatal slices taken from
2- to 3-week-old postnatal rats recorded at 24-26°C.
During periods of induced regular firing, intrastriatal stimuli were
used to evoke pharmacologically isolated monosynaptic AMPA
receptor-mediated EPSPs or GABAA receptor-mediated IPSPs. EPSPs evoked during the interspike interval (ISI) produced a
phase-dependent decrease in the ISI, whereas IPSPs produced a
phase-independent prolongation of the ISI. Injection of brief
depolarizing currents mimicked the action of EPSPs and revealed an
alteration in the input resistance during the ISI. In contrast to
IPSPs, the ability of brief hyperpolarizing current injections to delay
spike generation was phase-dependent. After blockade of GABAergic and
glutamatergic synaptic transmission, stimuli failed to produce a
detectable conductance change but could still prolong the subsequent
ISI primarily through a D1 dopamine receptor-mediated enhancement of
the afterhyperpolarization (AHP).
Hence, EPSPs are ideally suited to provide a precise regulation of
spike timing in cholinergic cells, whereas IPSPs are more likely to
influence the overall level of excitability. The D1-mediated modulation
of the AHP may contribute to the prolonged ISI seen in tonically active
neurons in vivo in monkeys trained to respond to a
sensory cue.
Key words:
neostriatum; basal ganglia; AMPA; GABAA; neuromodulation; firing; TANs; D1
receptors
Copyright © 1998 Society for Neuroscience 0270-6474/98/18208539-11$05.00/0
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