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Previous Article | Next Article
The Journal of Neuroscience, November 15, 1998, 18(22):9539-9546
Relationships between the Prefrontal Cortex and the Basal Ganglia in the Rat: Physiology of the Corticosubthalamic Circuits
Nicolas Maurice1, Jean-Michel Deniau2, Jacques Glowinski1, and Anne-Marie Thierry1 1 Chaire de Neuropharmacologie, Institut National de la Santé et de la Recherche Médicale U 114, Collège de France, 75231 Paris Cedex 05, France, and 2 Université Pierre et Marie Curie, Département de Neurochimie-Neuroanatomie, Institut des Neurosciences, Unité de Recherche Associée 1488, 75230 Paris Cedex 05, France
The prelimbic-medial orbital areas (PL/MO) of the prefrontal cortex are connected to the medial part of the subthalamic nucleus (STN) through a direct projection and an indirect circuit that involves the core of the nucleus accumbens (NAcc) and the ventral pallidum (VP). In the present study, the influence of the PL/MO on the discharge of STN cells has been characterized. The major pattern of the responses observed after stimulation of PL/MO consisted of two excitatory peaks often separated by a brief inhibitory period. The early excitation was most likely to be caused by the activation of direct cortical inputs because its latency matches the conduction time of the prefrontal STN projections. The late excitation resulted from the activation of the indirect PL/MO-STN pathway that operates through a disinhibitory process. Indeed, the late excitation was no longer observed after acute blockade of the glutamatergic corticostriatal transmission by CNQX application into the NAcc. A similar effect was obtained after the blockade of the GABAergic striatopallidal transmission by bicuculline application into the VP. Finally, the brief inhibition that followed the early excitation was likely to result from the activation of a feedback inhibitory loop through VP because this inhibition was no longer observed after the blockade of STN inputs by CNQX application into the VP. This study further indicates the implication of STN in prefrontal basal ganglia circuits and underlines that in addition to a direct excitatory input, medial STN receives an indirect excitatory influence from PL/MO through an NAcc-VP-STN disinhibitory circuit.
Key words: basal ganglia circuits; prefrontal cortex; subthalamic nucleus; ventral striatum; nucleus accumbens; ventral pallidum; in vivo single unit recordings; rat
Copyright © 1998 Society for Neuroscience 0270-6474/98/18229539-08$05.00/0
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