QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (178) Citing Articles via Google Scholar Google Scholar Articles by Harrington, D. L. Articles by Knight, R. T. Search for Related Content PubMed PubMed Citation Articles by Harrington, D. L. Articles by Knight, R. T.

 Previous Article  |  Next Article 

The Journal of Neuroscience, February 1, 1998, 18(3):1085-1095

Cortical Networks Underlying Mechanisms of Time Perception

Deborah L. Harrington¹, Kathleen Y. Haaland¹, and Robert T. Knight²

¹ Research and Psychology Services, Veterans Affairs Medical Center and the University of New Mexico, Albuquerque, New Mexico 87108, and ² Department of Neurology and Center for Neuroscience, University of California, Davis, and Veterans Affairs Medical Center, Martinez, California 94553

Precise timing of sensory information from multiple sensory streams is essential for many aspects of human perception and action. Animal and human research implicates the basal ganglia and cerebellar systems in timekeeping operations, but investigations into the role of the cerebral cortex have been limited. Individuals with focal left (LHD) or right hemisphere (RHD) lesions and control subjects performed two time perception tasks (duration perception, wherein the standard tone pair interval was 300 or 600 msec) and a frequency perception task, which controlled for deficits in time-independent processes shared by both tasks. When frequency perception deficits were controlled, only patients with RHD showed time perception deficits. Time perception competency was correlated with an independent test of switching nonspatial attention in the RHD but not the LHD patients, despite attention deficits in both groups. Lesion overlays of patients with RHD and impaired timing showed that 100% of the patients with anterior damage had lesions in premotor and prefrontal cortex (Brodmann areas 6, 8, 9, and 46), and 100% with posterior damage had lesions in the inferior parietal cortex. All LHD patients with normal timing had damage in these same regions, whereas few, if any, RHD patients with normal timing had similar lesion distributions. These results implicate a right hemisphere prefrontal-inferior parietal network in timing. Time-dependent attention and working memory functions may contribute to temporal perception deficits observed after damage to this network.

Key words: timing; hemispheric asymmetry; prefrontal cortex; inferior parietal cortex; basal ganglia; cerebellum; frequency perception; attention; working memory

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/1831085-11$05.00/0

This article has been cited by other articles:

				D. Bueti, B. Bahrami, and V. Walsh Sensory and association cortex in time perception. J. Cogn. Neurosci., June 1, 2008; 20(6): 1054 - 1062. [Abstract] [Full Text] [PDF]

				D. Bueti, V. Walsh, C. Frith, and G. Rees Different brain circuits underlie motor and perceptual representations of temporal intervals. J. Cogn. Neurosci., February 1, 2008; 20(2): 204 - 214. [Abstract] [Full Text] [PDF]

				J. Danckert, S. Ferber, C. Pun, C. Broderick, C. Striemer, S. Rock, and D. Stewart Neglected time: impaired temporal perception of multisecond intervals in unilateral neglect. J. Cogn. Neurosci., October 1, 2007; 19(10): 1706 - 1720. [Abstract] [Full Text] [PDF]

				G. L. Malcolm and J. J. S. Barton "Sequence Agnosia" in Balint's Syndrome: Defects in Visuotemporal Processing after Bilateral Parietal Damage. J. Cogn. Neurosci., January 1, 2007; 19(1): 102 - 108. [Abstract] [Full Text] [PDF]

				M. Fiorio, M. Gambarin, E. M. Valente, P. Liberini, M. Loi, G. Cossu, G. Moretto, K. P. Bhatia, G. Defazio, S. M. Aglioti, et al. Defective temporal processing of sensory stimuli in DYT1 mutation carriers: a new endophenotype of dystonia? Brain, January 1, 2007; 130(1): 134 - 142. [Abstract] [Full Text] [PDF]

				D. S. Bassett, A. Meyer-Lindenberg, S. Achard, T. Duke, and E. Bullmore From the Cover: Adaptive reconfiguration of fractal small-world human brain functional networks PNAS, December 19, 2006; 103(51): 19518 - 19523. [Abstract] [Full Text] [PDF]

				Y. Noguchi and R. Kakigi Time Representations Can Be Made from Nontemporal Information in the Brain: An MEG Study Cereb Cortex, December 1, 2006; 16(12): 1797 - 1808. [Abstract] [Full Text] [PDF]

				M. Jahanshahi, C. R. G. Jones, G. Dirnberger, and C. D. Frith The Substantia Nigra Pars Compacta and Temporal Processing. J. Neurosci., November 22, 2006; 26(47): 12266 - 12273. [Abstract] [Full Text] [PDF]

				G. Garraux, C. McKinney, T. Wu, K. Kansaku, G. Nolte, and M. Hallett Shared Brain Areas But Not Functional Connections Controlling Movement Timing and Order J. Neurosci., June 1, 2005; 25(22): 5290 - 5297. [Abstract] [Full Text] [PDF]

				R. B. Ivry and R. M. C. Spencer Evaluating the role of the cerebellum in temporal processing: beware of the null hypothesis Brain, August 1, 2004; 127(8): E13 - E13. [Full Text] [PDF]

				D. L. Harrington, R. R. Lee, L. A. Boyd, S. Z. Rapcsak, and R. T. Knight Reply to: Evaluating the role of the cerebellum in temporal processing: beware of the null hypothesis Brain, August 1, 2004; 127(8): E14 - E14. [Full Text] [PDF]

				K. J. Jantzen, F. L. Steinberg, and J. A. S. Kelso Brain networks underlying human timing behavior are influenced by prior context PNAS, April 27, 2004; 101(17): 6815 - 6820. [Abstract] [Full Text] [PDF]

				M. A. Pastor, B. L. Day, E. Macaluso, K. J. Friston, and R. S. J. Frackowiak The Functional Neuroanatomy of Temporal Discrimination J. Neurosci., March 10, 2004; 24(10): 2585 - 2591. [Abstract] [Full Text] [PDF]

				D. L. Harrington, R. R. Lee, L. A. Boyd, S. Z. Rapcsak, and R. T. Knight Does the representation of time depend on the cerebellum?: Effect of cerebellar stroke Brain, March 1, 2004; 127(3): 561 - 574. [Abstract] [Full Text] [PDF]

				G. Koch, M. Oliveri, S. Torriero, and C. Caltagirone Underestimation of time perception after repetitive transcranial magnetic stimulation Neurology, June 10, 2003; 60(11): 1844 - 1846. [Abstract] [Full Text] [PDF]

				S Katai, T Maruyama, T Hashimoto, and S Ikeda Event based and time based prospective memory in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, June 1, 2003; 74(6): 704 - 709. [Abstract] [Full Text] [PDF]

				U. R. Karmarkar and D. V. Buonomano Temporal Specificity of Perceptual Learning in an Auditory Discrimination Task Learn. Mem., March 1, 2003; 10(2): 141 - 147. [Abstract] [Full Text] [PDF]

				G. Koch, M. Oliveri, G. A. Carlesimo, and C. Caltagirone Selective deficit of time perception in a patient with right prefrontal cortex lesion Neurology, November 26, 2002; 59(10): 1658 - 1658. [Full Text] [PDF]

				N. Ramnani and R. E. Passingham Changes in the Human Brain during Rhythm Learning J. Cogn. Neurosci., October 1, 2001; 13(7): 952 - 966. [Abstract] [Full Text] [PDF]

				K. Y. Haaland, D. L. Harrington, and R. T. Knight Neural representations of skilled movement Brain, November 1, 2000; 123(11): 2306 - 2313. [Abstract] [Full Text] [PDF]

				C. Marshuetz, E. E. Smith, J. Jonides, J. DeGutis, and T. L. Chenevert Order Information in Working Memory: fMRI Evidence for Parietal and Prefrontal Mechanisms J. Cogn. Neurosci., November 1, 2000; 12(90002): 130S - 144. [Abstract] [Full Text]

				R. C. Leiguarda and C. D. Marsden Limb apraxias: Higher-order disorders of sensorimotor integration Brain, May 1, 2000; 123(5): 860 - 879. [Abstract] [Full Text] [PDF]

				D. V. Buonomano Decoding Temporal Information: A Model Based on Short-Term Synaptic Plasticity J. Neurosci., February 1, 2000; 20(3): 1129 - 1141. [Abstract] [Full Text] [PDF]

				C. D. Tesche and J. Karhu Theta oscillations index human hippocampal activation during a working memory task PNAS, January 18, 2000; 97(2): 919 - 924. [Abstract] [Full Text] [PDF]

				K. Sakai, O. Hikosaka, S. Miyauchi, R. Takino, T. Tamada, N. K. Iwata, and M. Nielsen Neural Representation of a Rhythm Depends on Its Interval Ratio J. Neurosci., November 15, 1999; 19(22): 10074 - 10081. [Abstract] [Full Text] [PDF]

				C. Miniussi, E. L. Wilding, J. T. Coull, and A. C. Nobre Orienting attention in time: Modulation of brain potentials Brain, August 1, 1999; 122(8): 1507 - 1518. [Abstract] [Full Text] [PDF]

				D. L. Harrington, S. M. Rao, K. Y. Haaland, J. A. Bobholz, A. R. Mayer, J. R. Binder, and R. W. Cox Specialized Neural Systems Underlying Representations of Sequential Movements J. Cogn. Neurosci., January 1, 1999; 12(1): 56 - 77. [Abstract] [Full Text]

				J. T. Coull and A. C. Nobre Where and When to Pay Attention: The Neural Systems for Directing Attention to Spatial Locations and to Time Intervals as Revealed by Both PET and fMRI J. Neurosci., September 15, 1998; 18(18): 7426 - 7435. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help