 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, February 1, 1998, 18(3):1161-1170
Variability and Correlated Noise in the Discharge of Neurons in Motor and Parietal Areas of the Primate Cortex
Daeyeol Lee1, 2, Nicholas L. Port1, 2, 5, Wolfgang Kruse1, 2, and Apostolos P. Georgopoulos1, 2, 3, 4, 5 1 Brain Sciences Center, Veterans Administration Medical Center, Minneapolis, Minnesota 55417, Departments of 2 Physiology, 3 Neurology, and 4 Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, and 5 Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455
We analyzed the magnitude and interneuronal correlation of the variability in the activity of single neurons that were recorded simultaneously using a multielectrode array in the primary motor cortex and parietal areas 2/5 in rhesus monkeys. The animals were trained to move their arms in one of eight directions as instructed by a visual target. The relationship between variability (SD) and mean of the discharge rate was described by a power function with a similar exponent (~0.57), regardless of the cortical area or the behavioral condition. We examined whether the deviation from mean activity between target onset and the end of the movement was correlated on a trial-by-trial basis with variability in activity during the hold period before target onset. In both cortical areas, for about a quarter of the neurons, the neuronal noise of these two periods was positively correlated, whereas significant negative correlations were seldom observed. Overall, neurons with higher signal correlation (i.e., similar directional pattern) showed higher noise correlation in both cortical areas. On the other hand, when the data were divided according to the distance between the electrode tips from which the neurons were recorded, a consistent relationship between the signal and noise correlations was found only for pairs of neurons recorded through the same electrode. These results suggest that nearby neurons with similar directional tuning carry primarily redundant messages, whereas neurons in separate cortical columns perform more independent processing.
Key words: directional tuning; motor cortex; noise correlation; parietal cortex; synchronized firing; rhesus monkey
Copyright © 1998 Society for Neuroscience 0270-6474/98/1831161-10$05.00/0
This article has been cited by other articles:
R. Moreno-Bote, A. Renart, and N. Parga
Theory of Input Spike Auto- and Cross-Correlations and Their Effect on the Response of Spiking Neurons
Neural Comput., July 1, 2008; 20(7): 1651 - 1705.
[Abstract] [Full Text] [PDF]
J. Poort and P. R. Roelfsema
Noise Correlations Have Little Influence on the Coding of Selective Attention in Area V1
Cereb Cortex, June 13, 2008; (2008) bhn103v1.
[Abstract] [Full Text] [PDF]
Y. Yanai, N. Adamit, R. Harel, Z. Israel, and Y. Prut
Connected Corticospinal Sites Show Enhanced Tuning Similarity at the Onset of Voluntary Action
J. Neurosci., November 7, 2007; 27(45): 12349 - 12357.
[Abstract] [Full Text] [PDF]
A. Nevet, G. Morris, G. Saban, D. Arkadir, and H. Bergman
Lack of Spike-Count and Spike-Time Correlations in the Substantia Nigra Reticulata Despite Overlap of Neural Responses
J Neurophysiol, October 1, 2007; 98(4): 2232 - 2243.
[Abstract] [Full Text] [PDF]
H. Seo, D. J. Barraclough, and D. Lee
Dynamic Signals Related to Choices and Outcomes in the Dorsolateral Prefrontal Cortex
Cereb Cortex, September 1, 2007; 17(suppl_1): i110 - i117.
[Abstract] [Full Text] [PDF]
J. F. Medina and S. G. Lisberger
Variation, Signal, and Noise in Cerebellar Sensory-Motor Processing for Smooth-Pursuit Eye Movements
J. Neurosci., June 20, 2007; 27(25): 6832 - 6842.
[Abstract] [Full Text] [PDF]
S. Deneve, J.-R. Duhamel, and A. Pouget
Optimal Sensorimotor Integration in Recurrent Cortical Networks: A Neural Implementation of Kalman Filters
J. Neurosci., May 23, 2007; 27(21): 5744 - 5756.
[Abstract] [Full Text] [PDF]
X. Hu, H. Jiang, C. Gu, C. Li, and D. L. Sparks
Reliability of oculomotor command signals carried by individual neurons
PNAS, May 8, 2007; 104(19): 8137 - 8142.
[Abstract] [Full Text] [PDF]
I. Asher, E. Stark, M. Abeles, and Y. Prut
Comparison of Direction and Object Selectivity of Local Field Potentials and Single Units in Macaque Posterior Parietal Cortex During Prehension
J Neurophysiol, May 1, 2007; 97(5): 3684 - 3695.
[Abstract] [Full Text] [PDF]
W. J. Kargo, B. Szatmary, and D. A. Nitz
Adaptation of Prefrontal Cortical Firing Patterns and Their Fidelity to Changes in Action-Reward Contingencies
J. Neurosci., March 28, 2007; 27(13): 3548 - 3559.
[Abstract] [Full Text] [PDF]
F. Montani, A. Kohn, M. A. Smith, and S. R. Schultz
The Role of Correlations in Direction and Contrast Coding in the Primary Visual Cortex
J. Neurosci., February 28, 2007; 27(9): 2338 - 2348.
[Abstract] [Full Text] [PDF]
F. Klam, R. S. Zemel, and A. Pouget
Population Coding with Motion Energy Filters: The Impact of Correlations
Neural Comput., January 1, 2007; 20(1): 146 - 175.
[Abstract] [Full Text] [PDF]
G. La Camera, A. Rauch, D. Thurbon, H.-R. Luscher, W. Senn, and S. Fusi
Multiple Time Scales of Temporal Response in Pyramidal and Fast Spiking Cortical Neurons
J Neurophysiol, December 1, 2006; 96(6): 3448 - 3464.
[Abstract] [Full Text] [PDF]
K. Karmeier, J. H. van Hateren, R. Kern, and M. Egelhaaf
Encoding of Naturalistic Optic Flow by a Population of Blowfly Motion-Sensitive Neurons
J Neurophysiol, September 1, 2006; 96(3): 1602 - 1614.
[Abstract] [Full Text] [PDF]
M. Shamir and H. Sompolinsky
Implications of Neuronal Diversity on Population Coding
Neural Comput., August 1, 2006; 18(8): 1951 - 1986.
[Abstract] [Full Text] [PDF]
B. B. Averbeck and D. Lee
Effects of Noise Correlations on Information Encoding and Decoding
J Neurophysiol, June 1, 2006; 95(6): 3633 - 3644.
[Abstract] [Full Text] [PDF]
H. Nakahara, S.-i. Amari, and B. J. Richmond
A comparison of descriptive models of a single spike train by information-geometric measure.
Neural Comput., March 1, 2006; 18(3): 545 - 568.
[Abstract] [Full Text] [PDF]
A. Lerchner, C. Ursta, J. Hertz, M. Ahmadi, P. Ruffiot, and S. Enemark
Response variability in balanced cortical networks.
Neural Comput., March 1, 2006; 18(3): 634 - 659.
[Abstract] [Full Text] [PDF]
P. Miller and X.-J. Wang
Power-Law Neuronal Fluctuations in a Recurrent Network Model of Parametric Working Memory
J Neurophysiol, February 1, 2006; 95(2): 1099 - 1114.
[Abstract] [Full Text] [PDF]
C. D. Takahashi, D. Nemet, C. M. Rose-Gottron, J. K. Larson, D. M. Cooper, and D. J. Reinkensmeyer
Effect of muscle fatigue on internal model formation and retention during reaching with the arm
J Appl Physiol, February 1, 2006; 100(2): 695 - 706.
[Abstract] [Full Text] [PDF]
J. M. Carmena, M. A. Lebedev, C. S. Henriquez, and M. A. L. Nicolelis
Stable Ensemble Performance with Single-Neuron Variability during Reaching Movements in Primates
J. Neurosci., November 16, 2005; 25(46): 10712 - 10716.
[Abstract] [Full Text] [PDF]
K. Karmeier, H. G. Krapp, and M. Egelhaaf
Population Coding of Self-Motion: Applying Bayesian Analysis to a Population of Visual Interneurons in the Fly
J Neurophysiol, September 1, 2005; 94(3): 2182 - 2194.
[Abstract] [Full Text] [PDF]
M. A. Lebedev, J. M. Carmena, J. E. O'Doherty, M. Zacksenhouse, C. S. Henriquez, J. C. Principe, and M. A. L. Nicolelis
Cortical Ensemble Adaptation to Represent Velocity of an Artificial Actuator Controlled by a Brain-Machine Interface
J. Neurosci., May 11, 2005; 25(19): 4681 - 4693.
[Abstract] [Full Text] [PDF]
A. Kohn and M. A. Smith
Stimulus Dependence of Neuronal Correlation in Primary Visual Cortex of the Macaque
J. Neurosci., April 6, 2005; 25(14): 3661 - 3673.
[Abstract] [Full Text] [PDF]
H. Homayoun, M. E. Jackson, and B. Moghaddam
Activation of Metabotropic Glutamate 2/3 Receptors Reverses the Effects of NMDA Receptor Hypofunction on Prefrontal Cortex Unit Activity in Awake Rats
J Neurophysiol, April 1, 2005; 93(4): 1989 - 2001.
[Abstract] [Full Text] [PDF]
L. Paninski, S. Shoham, M. R. Fellows, N. G. Hatsopoulos, and J. P. Donoghue
Superlinear Population Encoding of Dynamic Hand Trajectory in Primary Motor Cortex
J. Neurosci., September 29, 2004; 24(39): 8551 - 8561.
[Abstract] [Full Text] [PDF]
W. J. Kargo and D. A. Nitz
Improvements in the Signal-to-Noise Ratio of Motor Cortex Cells Distinguish Early versus Late Phases of Motor Skill Learning
J. Neurosci., June 16, 2004; 24(24): 5560 - 5569.
[Abstract] [Full Text] [PDF]
M. Shamir and H. Sompolinsky
Nonlinear Population Codes
Neural Comput., June 1, 2004; 16(6): 1105 - 1136.
[Abstract] [Full Text] [PDF]
D. Cohen and M. A. L. Nicolelis
Reduction of Single-Neuron Firing Uncertainty by Cortical Ensembles during Motor Skill Learning
J. Neurosci., April 7, 2004; 24(14): 3574 - 3582.
[Abstract] [Full Text] [PDF]
D. J. Reinkensmeyer, M. G. Iobbi, L. E. Kahn, D. G. Kamper, and C. D. Takahashi
Modeling Reaching Impairment After Stroke Using a Population Vector Model of Movement Control That Incorporates Neural Firing-Rate Variability
Neural Comput., November 1, 2003; 15(11): 2619 - 2642.
[Abstract] [Full Text] [PDF]
Y. Prut and S. I. Perlmutter
Firing Properties of Spinal Interneurons during Voluntary Movement. I. State-Dependent Regularity of Firing
J. Neurosci., October 22, 2003; 23(29): 9600 - 9610.
[Abstract] [Full Text] [PDF]
Y. Prut and S. I. Perlmutter
Firing Properties of Spinal Interneurons during Voluntary Movement. II. Interactions between Spinal Neurons
J. Neurosci., October 22, 2003; 23(29): 9611 - 9619.
[Abstract] [Full Text] [PDF]
M. R. DeWeese, M. Wehr, and A. M. Zador
Binary Spiking in Auditory Cortex
J. Neurosci., August 27, 2003; 23(21): 7940 - 7949.
[Abstract] [Full Text] [PDF]
B. B. Averbeck and D. Lee
Neural Noise and Movement-Related Codes in the Macaque Supplementary Motor Area
J. Neurosci., August 20, 2003; 23(20): 7630 - 7641.
[Abstract] [Full Text] [PDF]
C. D. Takahashi, D. Nemet, C. M. Rose-Gottron, J. K. Larson, D. M. Cooper, and D. J. Reinkensmeyer
Neuromotor Noise Limits Motor Performance, But Not Motor Adaptation, in Children
J Neurophysiol, August 1, 2003; 90(2): 703 - 711.
[Abstract] [Full Text] [PDF]
D. Lee
Coherent Oscillations in Neuronal Activity of the Supplementary Motor Area during a Visuomotor Task
J. Neurosci., July 30, 2003; 23(17): 6798 - 6809.
[Abstract] [Full Text] [PDF]
S. Panzeri, G. Pola, and R. S. Petersen
Coding of Sensory Signals by Neuronal Populations: The Role of Correlated Activity
Neuroscientist, June 1, 2003; 9(3): 175 - 180.
[Abstract] [PDF]
S. N. Baker, E. M. Pinches, and R. N. Lemon
Synchronization in Monkey Motor Cortex During a Precision Grip Task. II. Effect of Oscillatory Activity on Corticospinal Output
J Neurophysiol, April 1, 2003; 89(4): 1941 - 1953.
[Abstract] [Full Text] [PDF]
Y. Ben-Shaul, E. Stark, I. Asher, R. Drori, Z. Nadasdy, and M. Abeles
Dynamical Organization of Directional Tuning in the Primate Premotor and Primary Motor Cortex
J Neurophysiol, February 1, 2003; 89(2): 1136 - 1142.
[Abstract] [Full Text] [PDF]
C. Constantinidis and P. S. Goldman-Rakic
Correlated Discharges Among Putative Pyramidal Neurons and Interneurons in the Primate Prefrontal Cortex
J Neurophysiol, December 1, 2002; 88(6): 3487 - 3497.
[Abstract] [Full Text] [PDF]
E. Todorov
Cosine Tuning Minimizes Motor Errors
Neural Comput., June 1, 2002; 14(6): 1233 - 1260.
[Abstract] [Full Text]
S. Wu, S.-i. Amari, and H. Nakahara
Population Coding and Decoding in a Neural Field: A Computational Study
Neural Comput., May 1, 2002; 14(5): 999 - 1026.
[Abstract] [Full Text]
S.J.D. Prince, A. D. Pointon, B. G. Cumming, and A. J. Parker
Quantitative Analysis of the Responses of V1 Neurons to Horizontal Disparity in Dynamic Random-Dot Stereograms
J Neurophysiol, January 1, 2002; 87(1): 191 - 208.
[Abstract] [Full Text] [PDF]
S. D. Wilke and C. W. Eurich
Representational Accuracy of Stochastic Neural Populations
Neural Comput., January 1, 2002; 14(1): 155 - 189.
[Abstract] [Full Text] [PDF]
M. C. Wiener, M. W. Oram, Z. Liu, and B. J. Richmond
Consistency of Encoding in Monkey Visual Cortex
J. Neurosci., October 15, 2001; 21(20): 8210 - 8221.
[Abstract] [Full Text] [PDF]
M. W. Oram, N. G. Hatsopoulos, B. J. Richmond, and J. P. Donoghue
Excess Synchrony in Motor Cortical Neurons Provides Redundant Direction Information With That From Coarse Temporal Measures
J Neurophysiol, October 1, 2001; 86(4): 1700 - 1716.
[Abstract] [Full Text] [PDF]
H. E. Wheat and A. W. Goodwin
Tactile Discrimination of Edge Shape: Limits on Spatial Resolution Imposed by Parameters of the Peripheral Neural Population
J. Neurosci., October 1, 2001; 21(19): 7751 - 7763.
[Abstract] [Full Text] [PDF]
H. Nakahara, S. Wu, and S.-i. Amari
Attention Modulation of Neural Tuning Through Peak and Base Rate
Neural Comput., September 1, 2001; 13(9): 2031 - 2047.
[Abstract] [Full Text] [PDF]
C. Constantinidis, M. N. Franowicz, and P. S. Goldman-Rakic
Coding Specificity in Cortical Microcircuits: A Multiple-Electrode Analysis of Primate Prefrontal Cortex
J. Neurosci., May 15, 2001; 21(10): 3646 - 3655.
[Abstract] [Full Text] [PDF]
S. Wu, H. Nakahara, and S.-i. Amari
Population Coding with Correlation and an Unfaithful Model
Neural Comput., April 1, 2001; 13(4): 775 - 797.
[Abstract] [Full Text]
W. Bair, E. Zohary, and W. T. Newsome
Correlated Firing in Macaque Visual Area MT: Time Scales and Relationship to Behavior
J. Neurosci., March 1, 2001; 21(5): 1676 - 1697.
[Abstract] [Full Text] [PDF]
S. N. Baker, R. Spinks, A. Jackson, and R. N. Lemon
Synchronization in Monkey Motor Cortex During a Precision Grip Task. I. Task-Dependent Modulation in Single-Unit Synchrony
J Neurophysiol, February 1, 2001; 85(2): 869 - 885.
[Abstract] [Full Text] [PDF]
S. N. Baker and R. N. Lemon
Precise Spatiotemporal Repeating Patterns in Monkey Primary and Supplementary Motor Areas Occur at Chance Levels
J Neurophysiol, October 1, 2000; 84(4): 1770 - 1780.
[Abstract] [Full Text] [PDF]
H. E. Wheat and A. W. Goodwin
Tactile Discrimination of Gaps by Slowly Adapting Afferents: Effects of Population Parameters and Anisotropy in the Fingerpad
J Neurophysiol, September 1, 2000; 84(3): 1430 - 1444.
[Abstract] [Full Text] [PDF]
R. S. Petersen and M. E. Diamond
Spatial-Temporal Distribution of Whisker-Evoked Activity in Rat Somatosensory Cortex and the Coding of Stimulus Location
J. Neurosci., August 15, 2000; 20(16): 6135 - 6143.
[Abstract] [Full Text] [PDF]
M. W. Jung, Y. Qin, D. Lee, and I. Mook-Jung
Relationship among Discharges of Neighboring Neurons in the Rat Prefrontal Cortex During Spatial Working Memory Tasks
J. Neurosci., August 15, 2000; 20(16): 6166 - 6172.
[Abstract] [Full Text] [PDF]
Q. Pauluis and S. N. Baker
An Accurate Measure of the Instantaneous Discharge Probability, with Application to Unitary Joint-Event Analysis
Neural Comput., March 1, 2000; 12(3): 647 - 669.
[Abstract] [Full Text]
S. Furukawa, L. Xu, and J. C. Middlebrooks
Coding of Sound-Source Location by Ensembles of Cortical Neurons
J. Neurosci., February 1, 2000; 20(3): 1216 - 1228.
[Abstract] [Full Text] [PDF]
R. I. Grossman
BRAIN IMAGING
AJNR Am. J. Neuroradiol., January 1, 2000; 21(1): 9 - 18.
[Full Text] [PDF]
M. C. Wiener and B. J. Richmond
Using Response Models to Estimate Channel Capacity for Neuronal Classification of Stationary Visual Stimuli Using Temporal Coding
J Neurophysiol, Decemb
