 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, February 15, 1998, 18(4):1270-1279
D1/D5 Dopamine Receptors Inhibit Depotentiation at CA1 Synapses via cAMP-Dependent Mechanism
Nonna A. Otmakhova and John E. Lisman Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254
Recent work has shown that D1/D5 dopamine receptors can enhance long-term potentiation (LTP). We investigated whether D1/D5 receptors also affect depotentiation, the reversal of LTP by low-frequency stimulation. D1/D5 agonists greatly reduced depotentiation, an effect that was inhibited by a D1/D5 antagonist. The D1/D5 effect appears to be mediated by adenylyl cyclase (AC) and cAMP-dependent protein kinase (PKA), because it was mimicked by the AC activator forskolin and was inhibited by the AC and PKA inhibitors. In vivo studies show that dopamine is released when a reward occurs. Our results raise the possibility that the memory of events before reward might be retained selectively, because dopamine blocks their erasure.
Key words: adenylyl cyclase;
-adrenoreceptors; CA1; cAMP; cAMP-dependent protein kinase; depotentiation; D1/D5 dopamine receptors; early LTP; field EPSP; hippocampus; learning
Copyright © 1998 Society for Neuroscience 0270-6474/98/1841270-10$05.00/0
This article has been cited by other articles:
O. B. Kwon, D. Paredes, C. M. Gonzalez, J. Neddens, L. Hernandez, D. Vullhorst, and A. Buonanno
Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors
PNAS, October 7, 2008; 105(40): 15587 - 15592.
[Abstract] [Full Text] [PDF]
N. Granado, O. Ortiz, L. M. Suarez, E. D. Martin, V. Cena, J. M. Solis, and R. Moratalla
D1 but not D5 Dopamine Receptors Are Critical for LTP, Spatial Learning, and LTP-Induced arc and zif268 Expression in the Hippocampus
Cereb Cortex, January 1, 2008; 18(1): 1 - 12.
[Abstract] [Full Text] [PDF]
E. M. Izhikevich
Solving the Distal Reward Problem through Linkage of STDP and Dopamine Signaling
Cereb Cortex, October 1, 2007; 17(10): 2443 - 2452.
[Abstract] [Full Text] [PDF]
B. G. Mockett, D. Guevremont, J. M. Williams, and W. C. Abraham
Dopamine D1/D5 Receptor Activation Reverses NMDA Receptor-Dependent Long-Term Depression in Rat Hippocampus
J. Neurosci., March 14, 2007; 27(11): 2918 - 2926.
[Abstract] [Full Text] [PDF]
C. M. O'Carroll, S. J. Martin, J. Sandin, B. Frenguelli, and R. G.M. Morris
Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory
Learn. Mem., November 1, 2006; 13(6): 760 - 769.
[Abstract] [Full Text] [PDF]
N. Lemon and D. Manahan-Vaughan
Dopamine D1/D5 Receptors Gate the Acquisition of Novel Information through Hippocampal Long-Term Potentiation and Long-Term Depression
J. Neurosci., July 19, 2006; 26(29): 7723 - 7729.
[Abstract] [Full Text] [PDF]
N. A. Otmakhova, J. Lewey, B. Asrican, and J. E. Lisman
Inhibition of Perforant Path Input to the CA1 Region by Serotonin and Noradrenaline
J Neurophysiol, August 1, 2005; 94(2): 1413 - 1422.
[Abstract] [Full Text] [PDF]
D. H. O'Connor, G. M. Wittenberg, and S. S.-H. Wang
Dissection of Bidirectional Synaptic Plasticity Into Saturable Unidirectional Processes
J Neurophysiol, August 1, 2005; 94(2): 1565 - 1573.
[Abstract] [Full Text] [PDF]
M. A. Nitsche, J. Grundey, D. Liebetanz, N. Lang, F. Tergau, and W. Paulus
Catecholaminergic Consolidation of Motor Cortical Neuroplasticity in Humans
Cereb Cortex, November 1, 2004; 14(11): 1240 - 1245.
[Abstract] [Full Text] [PDF]
N. H. Woo and P. V. Nguyen
Protein Synthesis Is Required for Synaptic Immunity to Depotentiation
J. Neurosci., February 15, 2003; 23(4): 1125 - 1132.
[Abstract] [Full Text] [PDF]
S. Bao, V. T. Chan, L. I. Zhang, and M. M. Merzenich
Suppression of cortical representation through backward conditioning
PNAS, February 4, 2003; 100(3): 1405 - 1408.
[Abstract] [Full Text] [PDF]
D. Manahan-Vaughan and A. Kulla
Regulation of Depotentiation and Long-term Potentiation in the Dentate Gyrus of Freely Moving Rats by Dopamine D2-like Receptors
Cereb Cortex, February 1, 2003; 13(2): 123 - 135.
[Abstract] [Full Text] [PDF]
C.-H. Lin, C.-C. Lee, and P.-W. Gean
Involvement of a Calcineurin Cascade in Amygdala Depotentiation and Quenching of Fear Memory
Mol. Pharmacol., January 1, 2003; 63(1): 44 - 52.
[Abstract] [Full Text] [PDF]
N. Lezcano and C. Bergson
D1/D5 Dopamine Receptors Stimulate Intracellular Calcium Release in Primary Cultures of Neocortical and Hippocampal Neurons
J Neurophysiol, April 1, 2002; 87(4): 2167 - 2175.
[Abstract] [Full Text] [PDF]
S. Jones, J. L. Kornblum, and J. A. Kauer
Amphetamine Blocks Long-Term Synaptic Depression in the Ventral Tegmental Area
J. Neurosci., August 1, 2000; 20(15): 5575 - 5580.
[Abstract] [Full Text] [PDF]
N. A. Otmakhova, N. Otmakhov, L. H. Mortenson, and J. E. Lisman
Inhibition of the cAMP Pathway Decreases Early Long-Term Potentiation at CA1 Hippocampal Synapses
J. Neurosci., June 15, 2000; 20(12): 4446 - 4451.
[Abstract] [Full Text] [PDF]
A. Kulla and D. Manahan-Vaughan
Depotentiation in the Dentate Gyrus of Freely Moving Rats is Modulated by D1/D5 Dopamine Receptors
Cereb Cortex, June 1, 2000; 10(6): 614 - 620.
[Abstract] [Full Text] [PDF]
C.-C. Huang, Y.-C. Liang, and K.-S. Hsu
A Role for Extracellular Adenosine in Time-Dependent Reversal of Long-Term Potentiation by Low-Frequency Stimulation at Hippocampal CA1 Synapses
J. Neurosci., November 15, 1999; 19(22): 9728 - 9738.
[Abstract] [Full Text] [PDF]
N. A. Otmakhova and J. E. Lisman
Dopamine Selectively Inhibits the Direct Cortical Pathway to the CA1 Hippocampal Region
J. Neurosci., February 15, 1999; 19(4): 1437 - 1445.
[Abstract] [Full Text] [PDF]
D. A. Hoffman and D. Johnston
Downregulation of Transient K+ Channels in Dendrites of Hippocampal CA1 Pyramidal Neurons by Activation of PKA and PKC
J. Neurosci., May 15, 1998; 18(10): 3521 - 3528.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|