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The Journal of Neuroscience, February 15, 1998, 18(4):1428-1439
Widespread Elimination of Naturally Occurring Neuronal Death in
Bax-Deficient Mice
Fletcher A.
White1,
Cynthia R.
Keller-Peck1,
C.
Michael
Knudson2,
Stanley J.
Korsmeyer2, 3 and
William D.
Snider1
1 Department of Neurology, Center for the Study of
Nervous System Injury, 2 Departments of Pathology and
Medicine, and 3 Howard Hughes Medical Institute, Washington
University School of Medicine, St. Louis, Missouri 63110
The proapoptotic molecule BAX is required for death of sympathetic
and motor neurons in the setting of trophic factor deprivation. Furthermore, adult Bax / mice have more motor neurons
than do their wild-type counterparts. These findings raise the
possibility that BAX regulates naturally occurring cell death during
development in many neuronal populations. To test this idea, we
assessed apoptosis using TUNEL labeling in several well-studied neural
systems during embryonic and early postnatal development in
Bax/ mice. Remarkably, naturally occurring cell
death is virtually eliminated between embryonic day 11.5 (E11.5) and
postnatal day 1 (PN1) in most peripheral ganglia, in motor pools in the
spinal cord, and in the trigeminal brainstem nuclear complex.
Additionally, reduction, although not elimination, of cell death was
noted throughout the developing cerebellum, in some layers of the
retina, and in the hippocampus. Saving of cells was verified by axon
counts of dorsal and ventral roots, as well as facial and optic nerves
that revealed 24-35% increases in axon number. Interestingly, many of
the supernumerary axons had very small cross-sectional areas,
suggesting that the associated neurons are not normal. We conclude that
BAX is a critical mediator of naturally occurring death of peripheral
and CNS neurons during embryonic life. However, rescue from naturally
occurring cell death does not imply that the neurons will develop
normal functional capabilities.
Key words:
primary afferent neurons; motor neuron; apoptosis; programmed cell death; Bcl-2 gene family; BAX
Copyright © 1998 Society for Neuroscience 0270-6474/98/1841428-12$05.00/0
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135(24):
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135(24):
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28(47):
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149(9):
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135(9):
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[Full Text]
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|
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|
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28(14):
3577 - 3585.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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March 12, 2008;
28(11):
2941 - 2948.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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27(52):
14392 - 14403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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81(14):
7504 - 7516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Coultas, S. Terzano, T. Thomas, A. Voss, K. Reid, E. G. Stanley, C. L. Scott, P. Bouillet, P. Bartlett, J. Ham, et al.
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J. Cell Sci.,
June 15, 2007;
120(12):
2044 - 2052.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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134(11):
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[Full Text]
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|
|
|
|
|
|
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J. Jodoin, S. Laroche-Pierre, C. G. Goodyer, and A. C. LeBlanc
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J. Neurosci.,
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27(19):
5081 - 5091.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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104(12):
5229 - 5234.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Shacka, B. J. Klocke, C. Young, M. Shibata, J. W. Olney, Y. Uchiyama, P. Saftig, and K. A. Roth
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J. Neurosci.,
February 21, 2007;
27(8):
2081 - 2090.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. R. Buss, T. W. Gould, J. Ma, S. Vinsant, D. Prevette, A. Winseck, K. A. Toops, J. A. Hammarback, T. L. Smith, and R. W. Oppenheim
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26(52):
13413 - 13427.
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|
|
|
|
|
|
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6640 - 6652.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
H. K. Wong, M. Fricker, A. Wyttenbach, A. Villunger, E. M. Michalak, A. Strasser, and A. M. Tolkovsky
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25(19):
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[Abstract]
[Full Text]
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|
|
|
|
|
|
|
Y. Jiang, A. de Bruin, H. Caldas, J. Fangusaro, J. Hayes, E. M. Conway, M. L. Robinson, and R. A. Altura
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J. Neurosci.,
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25(30):
6962 - 6970.
[Abstract]
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[PDF]
|
|
|
|
|
|
|
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25(23):
5595 - 5603.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Jacob, C. L. Bengston, and N. G. Forger
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J. Neurosci.,
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25(23):
5638 - 5644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Lei, F. Laub, M. Lush, M. Romero, J. Zhou, B. Luikart, L. Klesse, F. Ramirez, and L. F. Parada
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June 1, 2005;
19(11):
1354 - 1364.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Hudson, P. J. Morris, D. S. Latchman, and V. S. Budhram-Mahadeo
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J. Biol. Chem.,
March 25, 2005;
280(12):
11851 - 11858.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Finnberg, J. J. Gruber, P. Fei, D. Rudolph, A. Bric, S.-H. Kim, T. F. Burns, H. Ajuha, R. Page, G. S. Wu, et al.
DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis
Mol. Cell. Biol.,
March 1, 2005;
25(5):
2000 - 2013.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Lingor, P. Koeberle, S. Kugler, and M. Bahr
Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo
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March 1, 2005;
128(3):
550 - 558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Weiner, X. Wang, J. C. Tapia, and J. R. Sanes
Inaugural Article: Gamma protocadherins are required for synaptic development in the spinal cord
PNAS,
January 4, 2005;
102(1):
8 - 14.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Chiesa, P. Piccardo, S. Dossena, L. Nowoslawski, K. A. Roth, B. Ghetti, and D. A. Harris
Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease
PNAS,
January 4, 2005;
102(1):
238 - 243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Sun, A. Winseck, S. Vinsant, O.-h. Park, H. Kim, and R. W. Oppenheim
Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene Bax
J. Neurosci.,
December 8, 2004;
24(49):
11205 - 11213.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Wiggins, G. Wei, E. Doxakis, C. Wong, A. A. Tang, K. Zang, E. J. Luo, R. L. Neve, L. F. Reichardt, and E. J. Huang
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
J. Cell Biol.,
October 25, 2004;
167(2):
257 - 267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. B. Jacobs, G. S. Walsh, and F. D. Miller
Neuronal Survival and p73/p63/p53: A Family Affair
Neuroscientist,
October 1, 2004;
10(5):
443 - 455.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. G. Forger, G. J. Rosen, E. M. Waters, D. Jacob, R. B. Simerly, and G. J. de Vries
Deletion of Bax eliminates sex differences in the mouse forebrain
PNAS,
September 14, 2004;
101(37):
13666 - 13671.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Yang, D. Bula, J. G. Arroyo, and D. F. Chen
Preventing Retinal Detachment-Associated Photoreceptor Cell Loss in Bax-Deficient Mice
Invest. Ophthalmol. Vis. Sci.,
February 1, 2004;
45(2):
648 - 654.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Dong, A. Fazzaro, C. Xiang, S. J. Korsmeyer, M. F. Jacquin, and J. W. McDonald
Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration
J. Neurosci.,
September 24, 2003;
23(25):
8682 - 8691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Wei, X.-M. Xia, J. Tang, H. Ao, S. Ko, J. Liauw, C.-S. Qiu, and M. Zhuo
Calmodulin Regulates Synaptic Plasticity in the Anterior Cingulate Cortex and Behavioral Responses: A Microelectroporation Study in Adult Rodents
J. Neurosci.,
September 10, 2003;
23(23):
8402 - 8409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Sun, T. W. Gould, S. Vinsant, D. Prevette, and R. W. Oppenheim
Neuromuscular Development after the Prevention of Naturally Occurring Neuronal Death by Bax Deletion
J. Neurosci.,
August 13, 2003;
23(19):
7298 - 7310.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gianino, J. R. Grider, J. Cresswell, H. Enomoto, and R. O. Heuckeroth
GDNF availability determines enteric neuron number by controlling precursor proliferation
Development,
May 15, 2003;
130(10):
2187 - 2198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bechade, C. Mallecourt, F. Sedel, S. Vyas, and A. Triller
Motoneuron-Derived Neurotrophin-3 Is a Survival Factor for PAX2-Expressing Spinal Interneurons
J. Neurosci.,
October 15, 2002;
22(20):
8779 - 8784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. R. Russell, Y. Lee, H. L. Miller, J. Zhao, and P. J. McKinnon
Murine Ovarian Development Is Not Affected by Inactivation of the Bcl-2 Family Member Diva
Mol. Cell. Biol.,
October 1, 2002;
22(19):
6866 - 6870.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Kerr, T. Larsen, S. H. Cook, Y.-R. Fannjiang, E. Choi, D. E. Griffin, J. M. Hardwick, and D. N. Irani
BCL-2 and BAX Protect Adult Mice from Lethal Sindbis Virus Infection but Do Not Protect Spinal Cord Motor Neurons or Prevent Paralysis
J. Virol.,
September 11, 2002;
76(20):
10393 - 10400.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Kirkland, J. A. Windelborn, J. M. Kasprzak, and J. L. Franklin
A Bax-Induced Pro-Oxidant State Is Critical for Cytochrome c Release during Programmed Neuronal Death
J. Neurosci.,
August 1, 2002;
22(15):
6480 - 6490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. P. Rakowicz, C. S. Staples, J. Milbrandt, J. E. Brunstrom, and E. M. Johnson Jr
Glial Cell Line-Derived Neurotrophic Factor Promotes the Survival of Early Postnatal Spinal Motor Neurons in the Lateral and Medial Motor Columns in Slice Culture
J. Neurosci.,
May 15, 2002;
22(10):
3953 - 3962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. Papermaster
The Birth and Death of Photoreceptors : The Friedenwald Lecture
Invest. Ophthalmol. Vis. Sci.,
May 1, 2002;
43(5):
1300 - 1309.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. D. Russell, H. Chiarini-Garcia, S. J. Korsmeyer, and C. M. Knudson
Bax-Dependent Spermatogonia Apoptosis Is Required for Testicular Development and Spermatogenesis
Biol Reprod,
April 1, 2002;
66(4):
950 - 958.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Windebank and E. Mcdonald
Book Review: Cell Death in the Peripheral Nervous System: Potential Rescue Strategies
Neuroscientist,
February 1, 2002;
8(1):
62 - 72.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Middleton and A. M. Davies
Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo
Development,
December 1, 2001;
128(23):
4715 - 4728.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-B. Charrier, F. Lapointe, N. M. L. Douarin, and M.-A. Teillet
Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis
Development,
October 15, 2001;
128(20):
4011 - 4020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Seidl, B. Bidmon, M. Bajo, B. C. Yoo, N. Cairns, E. C. LaCasse, and G. Lubec
Evidence for Apoptosis in the Fetal Down Syndrome Brain
J Child Neurol,
June 1, 2001;
16(6):
438 - 442.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G Middleton, S Wyatt, N Ninkina, and A. Davies
Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival
Development,
January 2, 2001;
128(3):
447 - 457.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Ghatan, S. Larner, Y. Kinoshita, M. Hetman, L. Patel, Z. Xia, R. J. Youle, and R. S. Morrison
p38 Map Kinase Mediates Bax Translocation in Nitric Oxide-Induced Apoptosis in Neurons
J. Cell Biol.,
July 24, 2000;
150(2):
335 - 348.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Selimi, M. W. Vogel, and J. Mariani
Bax Inactivation in Lurcher Mutants Rescues Cerebellar Granule Cells But Not Purkinje Cells or Inferior Olivary Neurons
J. Neurosci.,
July 15, 2000;
20(14):
5339 - 5345.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. V. Putcha, M. Deshmukh, and E. M. Johnson Jr.
Inhibition of Apoptotic Signaling Cascades Causes Loss of Trophic Factor Dependence during Neuronal Maturation
J. Cell Biol.,
May 29, 2000;
149(5):
1011 - 1018.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Doughty, P. L. De Jager, S. J. Korsmeyer, and N. Heintz
Neurodegeneration in Lurcher Mice Occurs via Multiple Cell Death Pathways
J. Neurosci.,
May 15, 2000;
20(10):
3687 - 3694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. F. X. ALMEIDA, G. L. CONDÉ, C. CROCHEMORE, B. A. DEMENEIX, D. FISCHER, A. H. S. HASSAN, M. MEYER, F. HOLSBOER, and T. M. MICHAELIDIS
Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate
FASEB J,
April 1, 2000;
14(5):
779 - 790.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. J. Chong, M. R. Murray, E. C. Gosink, H. R. C. Russell, A. Srinivasan, M. Kapsetaki, S. J. Korsmeyer, and P. J. McKinnon
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system
PNAS,
January 18, 2000;
97(2):
889 - 894.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Roth, C.-Y. Kuan, T. F. Haydar, C. D'Sa-Eipper, K. S. Shindler, T. S. Zheng, K. Kuida, R. A. Flavell, and P. Rakic
Epistatic and independent functions of Caspase-3 and Bcl-XL in developmental programmed cell death
PNAS,
January 4, 2000;
97(1):
466 - 471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Raoul, C. E. Henderson, and B. Pettmann
Programmed Cell Death of Embryonic Motoneurons Triggered through the FAS Death Receptor
J. Cell Biol.,
November 29, 1999;
147(5):
1049 - 1062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. V. Putcha, M. Deshmukh, and E. M. Johnson Jr
BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases
J. Neurosci.,
September 1, 1999;
19(17):
7476 - 7485.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. I. Lentz, C. M. Knudson, S. J. Korsmeyer, and W. D. Snider
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February 1, 1999;
19(3):
1038 - 1048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. Moulder, O. Onodera, J. R. Burke, W. J. Strittmatter, and E. M. Johnson Jr
Generation of Neuronal Intranuclear Inclusions by Polyglutamine-GFP: Analysis of Inclusion Clearance and Toxicity as a Function of Polyglutamine Length
J. Neurosci.,
January 15, 1999;
19(2):
705 - 715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Wetts and J. E. Vaughn
Peripheral and Central Target Requirements for Survival of Embryonic Rat Dorsal Root Ganglion Neurons in Slice Cultures
J. Neurosci.,
September 1, 1998;
18(17):
6905 - 6913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Vila, V. Jackson-Lewis, S. Vukosavic, R. Djaldetti, G. Liberatore, D. Offen, S. J. Korsmeyer, and S. Przedborski
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
PNAS,
February 27, 2001;
98(5):
2837 - 2842.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Linnarsson, A. Mikaels, C. Baudet, and P. Ernfors
Activation by GDNF of a transcriptional program repressing neurite growth in dorsal root ganglia
PNAS,
December 4, 2001;
98(25):
14681 - 14686.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Orike, G. Middleton, E. Borthwick, V. Buchman, T. Cowen, and A. M. Davies
Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons
J. Cell Biol.,
September 3, 2001;
154(5):
995 - 1006.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
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