 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, February 15, 1998, 18(4):1595-1601
Modulation of Hippocampal Acetylcholine Release and Spontaneous Alternation Scores by Intrahippocampal Glucose Injections
Michael E. Ragozzino, Shanthi N. Pal, Katharine Unick, Mark R. Stefani and Paul E. Gold Department of Psychology, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903
Recent evidence indicates that systemic glucose treatment enhances memory while producing a corresponding increase in hippocampal acetylcholine (ACh) output. The present experiments examined whether unilateral intrahippocampal infusions of glucose would enhance spontaneous alternation performance and whether there would be a corresponding increase in ACh output in the ipsilateral and contralateral hippocampus. Extracellular ACh was assessed in samples collected at 12 min intervals using in vivo microdialysis with HPLC with electrochemical detection. Twelve minutes after a unilateral infusion of artificial cerebrospinal fluid (CSF) or glucose (6.6 mM), rats were tested in a cross maze for spontaneous alternation behavior with concurrent microdialysis collection. In two experiments, glucose infusions significantly increased alternation scores (67.5 and 59%) compared with CSF controls (42.4 and 39.5%, respectively). In both experiments, behavioral testing resulted in increased ACh output in the hippocampus. Glucose administration at the time of alternation tests enhanced ACh output beyond that of behavioral testing alone both ipsilateral (+93.8%) and contralateral (+85%) to the infusion site, as compared with ACh output (+36.1% and +55.5%) of CSF controls. Glucose infusions did not affect hippocampal ACh output in rats kept in a holding chamber. These results suggest that glucose may enhance alternation scores by modulating ACh release. The findings also indicate that unilateral glucose infusions increase hippocampal ACh output both ipsilateral and contralateral to the site of injection. Furthermore, glucose increased ACh output only during maze testing, suggesting that specific behavioral demands, perhaps requiring activation of cholinergic neurons, determine the efficacy of glucose in modulating ACh release.
Key words: glucose; memory; learning; hippocampus; acetylcholine; microdialysis
Copyright © 1998 Society for Neuroscience 0270-6474/98/1841595-07$05.00/0
This article has been cited by other articles:
S. Ma, F. E. Olucha-Bordonau, M. A. Hossain, F. Lin, C. Kuei, C. Liu, J. D. Wade, S. W. Sutton, A. Nunez, and A. L. Gundlach
Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus
Learn. Mem., October 30, 2009; 16(11): 730 - 742.
[Abstract] [Full Text] [PDF]
A. L. Albiston, C. J. Morton, H. L. Ng, V. Pham, H. R. Yeatman, S. Ye, R. N. Fernando, D. De Bundel, D. B. Ascher, F. A. O. Mendelsohn, et al.
Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
FASEB J, December 1, 2008; 22(12): 4209 - 4217.
[Abstract] [Full Text] [PDF]
M Akhtar, K. Pillai, and D Vohora
Effect of thioperamide on oxidative stress markers in middle cerebral artery occlusion model of focal cerebral ischemia in rats
Human and Experimental Toxicology, October 1, 2008; 27(10): 761 - 767.
[Abstract] [PDF]
R. C. LENNARTZ
The role of extramaze cues in spontaneous alternation in a plus-maze
Learn Behav, May 1, 2008; 36(2): 138 - 144.
[Abstract] [PDF]
D. L. Krebs-Kraft, M. G. Wheeler, and M. B. Parent
The memory-impairing effects of septal GABA receptor activation involve GABAergic septo-hippocampal projection neurons
Learn. Mem., December 17, 2007; 14(12): 833 - 841.
[Abstract] [Full Text] [PDF]
A.-M. Linden, C. Sandu, M. I. Aller, O. Y. Vekovischeva, P. H. Rosenberg, W. Wisden, and E. R. Korpi
TASK-3 Knockout Mice Exhibit Exaggerated Nocturnal Activity, Impairments in Cognitive Functions, and Reduced Sensitivity to Inhalation Anesthetics
J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 924 - 934.
[Abstract] [Full Text] [PDF]
P. K. Dash, S. A. Orsi, and A. N. Moore
Spatial Memory Formation and Memory-Enhancing Effect of Glucose Involves Activation of the Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway
J. Neurosci., August 2, 2006; 26(31): 8048 - 8056.
[Abstract] [Full Text] [PDF]
J. C. Pych, Q. Chang, C. Colon-Rivera, R. Haag, and P. E. Gold
Acetylcholine release in the hippocampus and striatum during place and response training
Learn. Mem., November 1, 2005; 12(6): 564 - 572.
[Abstract] [Full Text] [PDF]
C. E. Canal, S. J. Stutz, and P. E. Gold
Glucose injections into the dorsal hippocampus or dorsolateral striatum of rats prior to T-maze training: Modulation of learning rates and strategy selection
Learn. Mem., July 1, 2005; 12(4): 367 - 374.
[Abstract] [Full Text] [PDF]
M. W. McElroy and D. L. Korol
Intrahippocampal muscimol shifts learning strategy in gonadally intact young adult female rats
Learn. Mem., March 1, 2005; 12(2): 150 - 158.
[Abstract] [Full Text] [PDF]
J. P. Schroeder and M. G. Packard
Facilitation of Memory for Extinction of Drug-Induced Conditioned Reward: Role of Amygdala and Acetylcholine
Learn. Mem., September 1, 2004; 11(5): 641 - 647.
[Abstract] [Full Text] [PDF]
M. B. Parent and M. G. Baxter
Septohippocampal Acetylcholine: Involved in but not Necessary for Learning and Memory?
Learn. Mem., January 1, 2004; 11(1): 9 - 20.
[Abstract] [Full Text] [PDF]
G. Pepeu and M. G. Giovannini
Changes in Acetylcholine Extracellular Levels During Cognitive Processes
Learn. Mem., January 1, 2004; 11(1): 21 - 27.
[Abstract] [Full Text] [PDF]
Q. Chang and P. E. Gold
Switching Memory Systems during Learning: Changes in Patterns of Brain Acetylcholine Release in the Hippocampus and Striatum in Rats
J. Neurosci., April 1, 2003; 23(7): 3001 - 3005.
[Abstract] [Full Text] [PDF]
R. J Kaplan, C. E Greenwood, G. Winocur, and T. M. Wolever
Dietary protein, carbohydrate, and fat enhance memory performance in the healthy elderly
Am. J. Clinical Nutrition, November 1, 2001; 74(5): 687 - 693.
[Abstract] [Full Text] [PDF]
R. J Kaplan, C. E Greenwood, G. Winocur, and T. M. Wolever
Reply to UN Das
Am. J. Clinical Nutrition, September 1, 2001; 74(3): 410 - 411.
[Full Text]
L. P. Reagan, N. Gorovits, E. K. Hoskin, S. E. Alves, E. B. Katz, C. A. Grillo, G. G. Piroli, B. S. McEwen, and M. J. Charron
Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats
PNAS, February 8, 2001; (2001) 51629798.
[Abstract] [Full Text]
E. C. McNay and P. E. Gold
Age-Related Differences in Hippocampal Extracellular Fluid Glucose Concentration During Behavioral Testing and Following Systemic Glucose Administration
J Gerontol A Biol Sci Med Sci, February 1, 2001; 56(2): B66 - B71.
[Abstract] [Full Text] [PDF]
M. R. Stefani and P. E. Gold
Intrahippocampal Infusions of K-ATP Channel Modulators Influence Spontaneous Alternation Performance: Relationships to Acetylcholine Release in the Hippocampus
J. Neurosci., January 15, 2001; 21(2): 609 - 614.
[Abstract] [Full Text] [PDF]
A. Degroot and M. B. Parent
Increasing Acetylcholine Levels in the Hippocampus or Entorhinal Cortex Reverses the Impairing Effects of Septal GABA Receptor Activation on Spontaneous Alternation
Learn. Mem., September 1, 2000; 7(5): 293 - 302.
[Abstract] [Full Text]
E. C. McNay, T. M. Fries, and P. E. Gold
Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task
PNAS, March 14, 2000; 97(6): 2881 - 2885.
[Abstract] [Full Text] [PDF]
L. P. Reagan, N. Gorovits, E. K. Hoskin, S. E. Alves, E. B. Katz, C. A. Grillo, G. G. Piroli, B. S. McEwen, and M. J. Charron
Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats
PNAS, February 27, 2001; 98(5): 2820 - 2825.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|