WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (49)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamaguchi, S.
Right arrow Articles by Kobayashi, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamaguchi, S.
Right arrow Articles by Kobayashi, S.

 Previous Article  |  Next Article 

The Journal of Neuroscience, March 1, 1998, 18(5):1869-1878

Contributions of the Dopaminergic System to Voluntary and Automatic Orienting of Visuospatial Attention

Shuhei Yamaguchi and Shotai Kobayashi

Department of Internal Medicine III, Shimane Medical University, Izumo 693, Japan

Visuospatial attention can be directed by voluntary or involuntary control independent of eye movement. The involvement of cortical and subcortical neural structures in this covert orienting mechanism has been studied using neuroimaging and electrophysiological techniques. This study was designed to investigate the role of the dopaminergic system in both voluntary and automatic orienting mechanisms of visuospatial attention. We recorded event-related evoked potentials (ERPs) and reaction time (RT) during a cued priming task in both patients with idiopathic Parkinson's disease (PD) and control subjects. Voluntary and automatic shifts in attention were studied by using central and peripheral cues, respectively. In the experiment using a central cue, the RT data showed that when the cue-target interval was long, PD patients' responses were delayed, and cue validity effects were reduced, whereas in the peripheral cue experiment the validity effects persisted across all trials. The ERPs demonstrated reduced sustained negativities preceding the imperative targets in both the central and peripheral cue experiments in PD patients. Furthermore, during the long cue-target interval in the central cue experiment, PD patients showed reduced attention shift-related negativities (ARNs) at the anterior scalp sites, whereas ARNs were generated widely in the peripheral cue experiment. The ERP findings were consistent with the RT data. These findings suggest that the dopaminergic system may contribute to voluntary and sustained control of visuospatial attention as well as to the neural system for response preparation, whereas automatic control of visuospatial attention is relatively independent of the dopamine system.

Key words: visuospatial attention; voluntary shift; automatic shift; dopamine system; Parkinson's disease; event-related evoked potential; cue; response preparation

Copyright © 1998 Society for Neuroscience  0270-6474/98/1851869-10$05.00/0


This article has been cited by other articles:


Home page
 BrainHome page
N. J. Cordato, A. J. Duggins, G. M. Halliday, J. G. L. Morris, and C. Pantelis
Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy
Brain, June 1, 2005; 128(6): 1259 - 1266.
[Abstract] [Full Text] [PDF]

Home page
 J PsychopharmacolHome page
M. A. Mehta, E. C. Hinton, A. J. Montgomery, R. A. Bantick, and P. M. Grasby
Sulpiride and mnemonic function: effects of a dopamine D2 receptor antagonist on working memory, emotional memory and long-term memory in healthy volunteers
J Psychopharmacol, January 1, 2005; 19(1): 29 - 38.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
P. N. Tobler, A. Dickinson, and W. Schultz
Coding of Predicted Reward Omission by Dopamine Neurons in a Conditioned Inhibition Paradigm
J. Neurosci., November 12, 2003; 23(32): 10402 - 10410.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. Williams, A. Kuhn, A. Kupsch, M. Tijssen, G. van Bruggen, H. Speelman, G. Hotton, K. Yarrow, and P. Brown
Behavioural cues are associated with modulations of synchronous oscillations in the human subthalamic nucleus
Brain, September 1, 2003; 126(9): 1975 - 1985.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. Poliakoff, D. J. O'Boyle, A. P. Moore, F. P. McGlone, F. W. J. Cody, and C. Spence
Orienting of attention and Parkinson's disease: tactile inhibition of return and response inhibition
Brain, September 1, 2003; 126(9): 2081 - 2092.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. N. Haber, J. L. Fudge, and N. R. McFarland
Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum
J. Neurosci., March 15, 2000; 20(6): 2369 - 2382.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. C. Davidson and R. T. Marrocco
Local Infusion of Scopolamine Into Intraparietal Cortex Slows Covert Orienting in Rhesus Monkeys
J Neurophysiol, March 1, 2000; 83(3): 1536 - 1549.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-