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The Journal of Neuroscience, April 1, 1998, 18(7):2423-2436
Role of Actin in Anchoring Postsynaptic Receptors in Cultured Hippocampal Neurons: Differential Attachment of NMDA versus AMPA Receptors
Daniel W. Allison1, Vladimir I. Gelfand1, Ilan Spector2, and Ann Marie Craig1 1 Department of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801, and 2 Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794
We used actin-perturbing agents and detergent extraction of primary hippocampal cultures to test directly the role of the actin cytoskeleton in localizing GABAA receptors, AMPA- and NMDA-type glutamate receptors, and potential anchoring proteins at postsynaptic sites. Excitatory postsynaptic sites on dendritic spines contained a high concentration of F-actin that was resistant to cytochalasin D but could be depolymerized using the novel compound latrunculin A. Depolymerization of F-actin led to a 40% decrease in both the number of synaptic NMDA receptor (NMDAR1) clusters and the number of AMPA receptor (GluR1)-labeled spines. The nonsynaptic NMDA receptors appeared to remain clustered and to coalesce in cell bodies.
-Actinin-2, which binds both actin and NMDA receptors, dissociated from the receptor clusters, but PSD-95 remained associated with both the synaptic and nonsynaptic receptor clusters, consistent with a proposed cross-linking function. AMPA receptors behaved differently; on GABAergic neurons, the clusters redistributed to nonsynaptic sites, whereas on pyramidal neurons, many of the clusters appeared to disperse. Furthermore, in control neurons, AMPA receptors were detergent extractable from pyramidal cell spines, whereas AMPA receptors on GABAergic neurons and NMDA receptors were unextractable. GABAA receptors were not dependent on F-actin for the maintenance or synaptic localization of clusters. These results indicate fundamental differences in the mechanisms of receptor anchoring at postsynaptic sites, both regarding the anchoring of a single receptor (the AMPA receptor) in pyramidal cells versus GABAergic interneurons and regarding the anchoring of different receptors (AMPA vs NMDA receptors) at a single class of postsynaptic sites on pyramidal cell dendritic spines.
Key words: actin; postsynaptic density; AMPA receptor; NMDA receptor; GABA receptor; dendritic spine; PSD-95
Copyright © 1998 Society for Neuroscience 0270-6474/98/1872423-14$05.00/0
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[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text] [PDF]
R. D. Shoop, N. Yamada, and D. K. Berg
Cytoskeletal Links of Neuronal Acetylcholine Receptors Containing alpha 7 Subunits
J. Neurosci., June 1, 2000; 20(11): 4021 - 4029.
[Abstract] [Full Text] [PDF]
C. Racca, F. A. Stephenson, P. Streit, J. D. B. Roberts, and P. Somogyi
NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 Area
J. Neurosci., April 1, 2000; 20(7): 2512 - 2522.
[Abstract] [Full Text] [PDF]
S. N. Gomperts, R. Carroll, R. C. Malenka, and R. A. Nicoll
Distinct Roles for Ionotropic and Metabotropic Glutamate Receptors in the Maturation of Excitatory Synapses
J. Neurosci., March 15, 2000; 20(6): 2229 - 2237.
[Abstract] [Full Text] [PDF]
P. Penzes, R. C. Johnson, M. R. Alam, V. Kambampati, R. E. Mains, and B. A. Eipper
An Isoform of Kalirin, a Brain-specific GDP/GTP Exchange Factor, Is Enriched in the Postsynaptic Density Fraction
J. Biol. Chem., February 25, 2000; 275(9): 6395 - 6403.
[Abstract] [Full Text] [PDF]
A. F. Ernst, G. Gallo, P. C. Letourneau, and S. C. McLoon
Stabilization of Growing Retinal Axons by the Combined Signaling of Nitric Oxide and Brain-Derived Neurotrophic Factor
J. Neurosci., February 15, 2000; 20(4): 1458 - 1469.
[Abstract] [Full Text] [PDF]
R. Sattler, Z. Xiong, W.-Y. Lu, J. F. MacDonald, and M. Tymianski
Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity
J. Neurosci., January 1, 2000; 20(1): 22 - 33.
[Abstract] [Full Text] [PDF]
Q.-s. Liu and D. K. Berg
Actin Filaments and the Opposing Actions of CaM Kinase II and Calcineurin in Regulating alpha 7-Containing Nicotinic Receptors on Chick Ciliary Ganglion Neurons
J. Neurosci., December 1, 1999; 19(23): 10280 - 10288.
[Abstract] [Full Text] [PDF]
A. Dunaevsky, A. Tashiro, A. Majewska, C. Mason, and R. Yuste
Developmental regulation of spine motility in the mammalian central nervous system
PNAS, November 9, 1999; 96(23): 13438 - 13443.
[Abstract] [Full Text] [PDF]
R. Gerlai, N. Shinsky, A. Shih, P. Williams, J. Winer, M. Armanini, B. Cairns, J. Winslow, W.-Q. Gao, and H. S. Phillips
Regulation of Learning by EphA Receptors: a Protein Targeting Study
J. Neurosci., November 1, 1999; 19(21): 9538 - 9549.
[Abstract] [Full Text] [PDF]
Y. Shiraishi, A. Mizutani, H. Bito, K. Fujisawa, S. Narumiya, K. Mikoshiba, and T. Furuichi
Cupidin, an Isoform of Homer/Vesl, Interacts with the Actin Cytoskeleton and Activated Rho Family Small GTPases and Is Expressed in Developing Mouse Cerebellar Granule Cells
J. Neurosci., October 1, 1999; 19(19): 8389 - 8400.
[Abstract] [Full Text] [PDF]
L. D. Walensky, S. Blackshaw, D. Liao, C. C. Watkins, H.-U. G. Weier, M. Parra, R. L. Huganir, J. G. Conboy, N. Mohandas, and S. H. Snyder
A Novel Neuron-Enriched Homolog of the Erythrocyte Membrane Cytoskeletal Protein 4.1
J. Neurosci., August 1, 1999; 19(15): 6457 - 6467.
[Abstract] [Full Text] [PDF]
M. Wyszynski, J. G. Valtschanoff, S. Naisbitt, A. W. Dunah, E. Kim, D. G. Standaert, R. Weinberg, and M. Sheng
Association of AMPA Receptors with a Subset of Glutamate Receptor-Interacting Protein In Vivo
J. Neurosci., August 1, 1999; 19(15): 6528 - 6537.
[Abstract] [Full Text] [PDF]
C.-H. Kim and J. E. Lisman
A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation
J. Neurosci., June 1, 1999; 19(11): 4314 - 4324.
[Abstract] [Full Text] [PDF]
K. Hayashi and T. Shirao
Change in the Shape of Dendritic Spines Caused by Overexpression of Drebrin in Cultured Cortical Neurons
J. Neurosci., May 15, 1999; 19(10): 3918 - 3925.
[Abstract] [Full Text] [PDF]
R. Dingledine, K. Borges, D. Bowie, and S. F. Traynelis
The Glutamate Receptor Ion Channels
Pharmacol. Rev., March 1, 1999; 51(1): 7 - 62.
[Abstract] [Full Text] [PDF]
D. V. Lissin, R. C. Carroll, R. A. Nicoll, R. C. Malenka, and M. v. Zastrow
Rapid, Activation-Induced Redistribution of Ionotropic Glutamate Receptors in Cultured Hippocampal Neurons
J. Neurosci., February 15, 1999; 19(4): 1263 - 1272.
[Abstract] [Full Text] [PDF]
T. Furuyashiki, K. Fujisawa, A. Fujita, P. Madaule, S. Uchino, M. Mishina, H. Bito, and S. Narumiya
Citron, a Rho-Target, Interacts with PSD-95/SAP-90 at Glutamatergic Synapses in the Thalamus
J. Neurosci., January 1, 1999; 19(1): 109 - 118.
[Abstract] [Full Text] [PDF]
S. Halpain, A. Hipolito, and L. Saffer
Regulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin
J. Neurosci., December 1, 1998; 18(23): 9835 - 9844.
[Abstract] [Full Text] [PDF]
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