QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (37) Citing Articles via Google Scholar Google Scholar Articles by Khasar, S. G. Articles by Levine, J. D. Search for Related Content PubMed PubMed Citation Articles by Khasar, S. G. Articles by Levine, J. D.

 Previous Article  |  Next Article 

The Journal of Neuroscience, April 15, 1998, 18(8):3043-3049

Vagotomy-Induced Enhancement of Mechanical Hyperalgesia in the Rat Is Sympathoadrenal-Mediated

Sachia G. Khasar¹, Frederick J.-P. Miao¹, Wilfrid Jänig², and Jon D. Levine¹

¹ Departments of Anatomy, Medicine, and Oral and Maxillofacial Surgery, Division of Neuroscience and Biomedical Sciences Program, University of California at San Francisco, San Francisco, California 94143-0452, and ² Physiologisches Institut, Christian-Albrechts-Universität zu Kiel, 24098 Kiel, Germany

We have recently shown that subdiaphragmatic vagotomy enhances bradykinin-induced hyperalgesic behavior and decreases baseline paw withdrawal threshold to mechanical stimulation of the hindpaw skin in rats by a peripheral mechanism. To elucidate the underlying mechanism, we studied whether lesions of efferent neuroendocrine pathways could prevent or reverse the potentiating effect of vagotomy. In groups of sham-vagotomized or vagotomized rats, we surgically removed or denervated the adrenal medulla. Bradykinin was injected intradermally into the skin of the dorsal surface of the rat hindpaw. Threshold of paw withdrawal to mechanical stimulation of the skin was measured.

Vagotomy induced a decrease in mechanical baseline paw withdrawal threshold and enhancement of bradykinin-induced mechanical hyperalgesic behavior, both of which were maintained over the 5 week testing period. Adrenal enucleation or denervation of the adrenal gland by suprarenal ganglionectomy prevented vagotomy-induced decrease in baseline paw withdrawal threshold and enhancement of bradykinin-induced hyperalgesia. In animals that had a demonstrated decrease in baseline paw withdrawal threshold and enhancement of bradykinin-induced hyperalgesia 2 weeks after vagotomy, additional denervation of the adrenal medulla significantly reversed these effects over a 3 week period.

These results imply that both the decrease in baseline paw withdrawal threshold and enhancement of bradykinin-induced hyperalgesic behavior after vagotomy are dependent on a hormonal signal released from the adrenal medulla and suggest a novel mechanism of sensitization of cutaneous nociceptors.

Key words: bradykinin; hyperalgesia; nociception; pain; sympathoadrenal system; vagus

---

Copyright © 1998 Society for Neuroscience  0270-6474/98/1883043-07$05.00/0

This article has been cited by other articles:

				W. R. Reed, H. K. Chadha, and C. H. Hubscher Effects of 17{beta}-Estradiol on Responses of Viscerosomatic Convergent Thalamic Neurons in the Ovariectomized Female Rat J Neurophysiol, August 1, 2009; 102(2): 1062 - 1074. [Abstract] [Full Text] [PDF]

				S. G. Khasar, J. Burkham, O. A. Dina, A. S. Brown, O. Bogen, N. Alessandri-Haber, P. G. Green, D. B. Reichling, and J. D. Levine Stress Induces a Switch of Intracellular Signaling in Sensory Neurons in a Model of Generalized Pain J. Neurosci., May 28, 2008; 28(22): 5721 - 5730. [Abstract] [Full Text] [PDF]

				C. H. Hubscher and R. D. Johnson Effects of Chronic Dorsal Column Lesions on Pelvic Viscerosomatic Convergent Medullary Reticular Formation Neurons J Neurophysiol, December 1, 2004; 92(6): 3596 - 3600. [Abstract] [Full Text] [PDF]

				C. Vogel, R. Mossner, M. Gerlach, T. Heinemann, D. L. Murphy, P. Riederer, K.-P. Lesch, and C. Sommer Absence of Thermal Hyperalgesia in Serotonin Transporter-Deficient Mice J. Neurosci., January 15, 2003; 23(2): 708 - 715. [Abstract] [Full Text] [PDF]

				K. O. Aley, A. Martin, T. McMahon, J. Mok, J. D. Levine, and R. O. Messing Nociceptor Sensitization by Extracellular Signal-Regulated Kinases J. Neurosci., September 1, 2001; 21(17): 6933 - 6939. [Abstract] [Full Text] [PDF]

				E. Lancaster, E. J. Oh, and D. Weinreich Vagotomy Decreases Excitability in Primary Vagal Afferent Somata J Neurophysiol, January 1, 2001; 85(1): 247 - 253. [Abstract] [Full Text] [PDF]

				F. J.-P. Miao, W. Janig, and J. D Levine Nociceptive neuroendocrine negative feedback control of neurogenic inflammation activated by capsaicin in the rat paw: role of the adrenal medulla J. Physiol., September 15, 2000; 527(3): 601 - 610. [Abstract] [Full Text] [PDF]

				S. G. Khasar, G. McCarter, and J. D. Levine Epinephrine Produces a beta -Adrenergic Receptor-Mediated Mechanical Hyperalgesia and In Vitro Sensitization of Rat Nociceptors J Neurophysiol, March 1, 1999; 81(3): 1104 - 1112. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help