 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, May 1, 1998, 18(9):3327-3335
Development of the Mouse Inner Ear and Origin of Its Sensory Organs
Hakim Morsli1, Daniel Choo1, Allen Ryan2, Randy Johnson3, and Doris K. Wu1 1 National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, 2 Departments of Surgery/Otolaryngology and Neurosciences, School of Medicine, and Veterans Administration Medical Center, University of California at San Diego, La Jolla, California 92093-0666, and 3 M. D. Anderson Cancer Center, University of Texas, Department of Biochemistry and Molecular Biology, Houston, Texas 77030-4095
The molecular mechanisms dictating the morphogenesis and differentiation of the mammalian inner ear are largely unknown. To better elucidate the normal development of this organ, two approaches were taken. First, the membranous labyrinths of mouse inner ears ranging from 10.25 to 17 d postcoitum (dpc) were filled with paint to reveal their gross development. Particular attention was focused on the developing utricle, saccule, and cochlea. Second, we used bone morphogenetic protein 4 (BMP4) and lunatic fringe (Fng) as molecular markers to identify the origin of the sensory structures. Our data showed that BMP4 was an early marker for the superior, lateral, and posterior cristae, whereas Fng served as an early marker for the macula utriculi, macula sacculi, and the sensory portion of the cochlea. The posterior crista was the first organ to appear at 11.5 dpc and was followed by the superior crista, the lateral crista, and the macula utriculi at 12 dpc. The macula sacculi and the cochlea were present at 12 dpc but became distinguishable from each other by 13 dpc. Based on the gene expression patterns, the anterior and lateral cristae may share a common origin. Similarly, three sensory organs, the macula utriculi, macula sacculi, and cochlea, seem to arise from a single region of the otocyst.
Key words: inner ear development; sensory organs; lunatic fringe; BMP4; NT-3; Brn3.1
Copyright © 1998 Society for Neuroscience 0270-6474/98/1893327-09$05.00/0
This article has been cited by other articles:
D. Zou, C. Erickson, E.-H. Kim, D. Jin, B. Fritzsch, and P.-X. Xu
Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear
Hum. Mol. Genet., November 1, 2008; 17(21): 3340 - 3356.
[Abstract] [Full Text] [PDF]
C. S. Jayasena, T. Ohyama, N. Segil, and A. K. Groves
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
Development, July 1, 2008; 135(13): 2251 - 2261.
[Abstract] [Full Text] [PDF]
Z. Chen, M. Montcouquiol, R. Calderon, N. A. Jenkins, N. G. Copeland, M. W. Kelley, and K. Noben-Trauth
Jxc1/Sobp, Encoding a Nuclear Zinc Finger Protein, Is Critical for Cochlear Growth, Cell Fate, and Patterning of the Organ of Corti
J. Neurosci., June 25, 2008; 28(26): 6633 - 6641.
[Abstract] [Full Text] [PDF]
T. Hayashi, C. A. Ray, and O. Bermingham-McDonogh
Fgf20 Is Required for Sensory Epithelial Specification in the Developing Cochlea
J. Neurosci., June 4, 2008; 28(23): 5991 - 5999.
[Abstract] [Full Text] [PDF]
C.-H. Hwang and D. K. Wu
Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans
Hum. Mol. Genet., March 15, 2008; 17(6): 844 - 853.
[Abstract] [Full Text] [PDF]
A. Li, J. Xue, and E. H. Peterson
Architecture of the Mouse Utricle: Macular Organization and Hair Bundle Heights
J Neurophysiol, February 1, 2008; 99(2): 718 - 733.
[Abstract] [Full Text] [PDF]
S. Raft, E. J. Koundakjian, H. Quinones, C. S. Jayasena, L. V. Goodrich, J. E. Johnson, N. Segil, and A. K. Groves
Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development
Development, December 15, 2007; 134(24): 4405 - 4415.
[Abstract] [Full Text] [PDF]
E. P. Hatch, C. A. Noyes, X. Wang, T. J. Wright, and S. L. Mansour
Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium
Development, October 15, 2007; 134(20): 3615 - 3625.
[Abstract] [Full Text] [PDF]
S. A. Sajan, M. E. Warchol, and M. Lovett
Toward a Systems Biology of Mouse Inner Ear Organogenesis: Gene Expression Pathways, Patterns and Network Analysis
Genetics, September 1, 2007; 177(1): 631 - 653.
[Abstract] [Full Text] [PDF]
S. Xu, P. D. Witmer, S. Lumayag, B. Kovacs, and D. Valle
MicroRNA (miRNA) Transcriptome of Mouse Retina and Identification of a Sensory Organ-specific miRNA Cluster
J. Biol. Chem., August 24, 2007; 282(34): 25053 - 25066.
[Abstract] [Full Text] [PDF]
N. Daudet, L. Ariza-McNaughton, and J. Lewis
Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear
Development, June 15, 2007; 134(12): 2369 - 2378.
[Abstract] [Full Text] [PDF]
J. Bok, D. K. Dolson, P. Hill, U. Ruther, D. J. Epstein, and D. K. Wu
Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear
Development, May 1, 2007; 134(9): 1713 - 1722.
[Abstract] [Full Text] [PDF]
L. S. Tang, H. M. Alger, and F. A. Pereira
COUP-TFI controls Notch regulation of hair cell and support cell differentiation
Development, September 15, 2006; 133(18): 3683 - 3693.
[Abstract] [Full Text] [PDF]
R. Brooker, K. Hozumi, and J. Lewis
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
Development, April 1, 2006; 133(7): 1277 - 1286.
[Abstract] [Full Text] [PDF]
Z. Lin, R. Cantos, M. Patente, and D. K. Wu
Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
Development, May 15, 2005; 132(10): 2309 - 2318.
[Abstract] [Full Text] [PDF]
N. Daudet and J. Lewis
Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation
Development, February 1, 2005; 132(3): 541 - 551.
[Abstract] [Full Text] [PDF]
R. D. Hawkins and M. Lovett
The developmental genetics of auditory hair cells
Hum. Mol. Genet., October 1, 2004; 13(suppl_2): R289 - R296.
[Abstract] [Full Text] [PDF]
K. F. Barald and M. W. Kelley
From placode to polarization: new tunes in inner ear development
Development, September 1, 2004; 131(17): 4119 - 4130.
[Abstract] [Full Text] [PDF]
S. Raft, S. Nowotschin, J. Liao, and B. E. Morrow
Suppression of neural fate and control of inner ear morphogenesis by Tbx1
Development, April 15, 2004; 131(8): 1801 - 1812.
[Abstract] [Full Text] [PDF]
H. Ozaki, K. Nakamura, J.-i. Funahashi, K. Ikeda, G. Yamada, H. Tokano, H.-o. Okamura, K. Kitamura, S. Muto, H. Kotaki, et al.
Six1 controls patterning of the mouse otic vesicle
Development, February 1, 2004; 131(3): 551 - 562.
[Abstract] [Full Text] [PDF]
Y. Alvarez, M. T. Alonso, V. Vendrell, L. C. Zelarayan, P. Chamero, T. Theil, M. R. Bosl, S. Kato, M. Maconochie, D. Riethmacher, et al.
Requirements for FGF3 and FGF10 during inner ear formation
Development, December 22, 2003; 130(25): 6329 - 6338.
[Abstract] [Full Text] [PDF]
W. Zheng, L. Huang, Z.-B. Wei, D. Silvius, B. Tang, and P.-X. Xu
The role of Six1 in mammalian auditory system development
Development, September 1, 2003; 130(17): 3989 - 4000.
[Abstract] [Full Text] [PDF]
F. Vitelli, A. Viola, M. Morishima, T. Pramparo, A. Baldini, and E. Lindsay
TBX1 is required for inner ear morphogenesis
Hum. Mol. Genet., August 15, 2003; 12(16): 2041 - 2048.
[Abstract] [Full Text] [PDF]
D. L. Thompson, L. M. Gerlach-Bank, K. F. Barald, and R. J. Koenig
Retinoic Acid Repression of Bone Morphogenetic Protein 4 in Inner Ear Development
Mol. Cell. Biol., April 1, 2003; 23(7): 2277 - 2286.
[Abstract] [Full Text] [PDF]
P. Chen, J. E. Johnson, H. Y. Zoghbi, and N. Segil
The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
Development, March 7, 2003; 129(10): 2495 - 2505.
[Abstract] [Full Text] [PDF]
L. M. Peters, D. W. Anderson, A. J. Griffith, K. M. Grundfast, T. B. San Agustin, A. C. Madeo, T. B. Friedman, and R. J. Morell
Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28
Hum. Mol. Genet., November 1, 2002; 11(23): 2877 - 2885.
[Abstract] [Full Text] [PDF]
J. Bryant, R. J Goodyear, and G. P Richardson
Sensory organ development in the inner ear: molecular and cellular mechanisms
Br. Med. Bull., October 1, 2002; 63(1): 39 - 57.
[Abstract] [Full Text] [PDF]
M. M. Riccomagno, L. Martinu, M. Mulheisen, D. K. Wu, and D. J. Epstein
Specification of the mammalian cochlea is dependent on Sonic hedgehog
Genes & Dev., September 15, 2002; 16(18): 2365 - 2378.
[Abstract] [Full Text] [PDF]
T. Ponnio, Q. Burton, F. A. Pereira, D. K. Wu, and O. M. Conneely
The Nuclear Receptor Nor-1 Is Essential for Proliferation of the Semicircular Canals of the Mouse Inner Ear
Mol. Cell. Biol., February 1, 2002; 22(3): 935 - 945.
[Abstract] [Full Text] [PDF]
I. Farinas, K. R. Jones, L. Tessarollo, A. J. Vigers, E. Huang, M. Kirstein, D. C. de Caprona, V. Coppola, C. Backus, L. F. Reichardt, et al.
Spatial Shaping of Cochlear Innervation by Temporally Regulated Neurotrophin Expression
J. Neurosci., August 15, 2001; 21(16): 6170 - 6180.
[Abstract] [Full Text] [PDF]
B. Boeda, D. Weil, and C. Petit
A specific promoter of the sensory cells of the inner ear defined by transgenesis
Hum. Mol. Genet., July 1, 2001; 10(15): 1581 - 1589.
[Abstract] [Full Text] [PDF]
E. J. Huang, W. Liu, B. Fritzsch, L. M. Bianchi, L. F. Reichardt, and M. Xiang
Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons
Development, July 1, 2001; 128(13): 2421 - 2432.
[Abstract] [Full Text] [PDF]
A. E. Kiernan, N. Ahituv, H. Fuchs, R. Balling, K. B. Avraham, K. P. Steel, and M. H. de Angelis
The Notch ligand Jagged1 is required for inner ear sensory development
PNAS, March 16, 2001; (2001) 71496998.
[Abstract] [Full Text]
L. A. Everett, I. A. Belyantseva, K. Noben-Trauth, R. Cantos, A. Chen, S. I. Thakkar, S. L. Hoogstraten-Miller, B. Kachar, D. K. Wu, and E. D. Green
Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome
Hum. Mol. Genet., January 1, 2001; 10(2): 153 - 161.
[Abstract] [Full Text] [PDF]
M. Liu, F. A. Pereira, S. D. Price, M.-j. Chu, C. Shope, D. Himes, R. A. Eatock, W. E. Brownell, A. Lysakowski, and M.-J. Tsai
Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems
Genes & Dev., November 15, 2000; 14(22): 2839 - 2854.
[Abstract] [Full Text]
R. Cantos, L. K. Cole, D. Acampora, A. Simeone, and D. K. Wu
Patterning of the mammalian cochlea
PNAS, October 24, 2000; 97(22): 11707 - 11713.
[Abstract] [Full Text] [PDF]
J. Weir, M. N. Rivolta, and M. C. Holley
Notch Signaling and the Emergence of Auditory Hair Cells
Arch Otolaryngol Head Neck Surg, October 1, 2000; 126(10): 1244 - 1248.
[Abstract] [Full Text] [PDF]
U. Pirvola, B. Spencer-Dene, L. Xing-Qun, P. Kettunen, I. Thesleff, B. Fritzsch, C. Dickson, and J. Ylikoski
FGF/FGFR-2(IIIb) Signaling Is Essential for Inner Ear Morphogenesis
J. Neurosci., August 15, 2000; 20(16): 6125 - 6134.
[Abstract] [Full Text] [PDF]
D. W. Anderson, F. J. Probst, I. A. Belyantseva, R. A. Fridell, L. Beyer, D. M. Martin, D. Wu, B. Kachar, T. B. Friedman, Y. Raphael, et al.
The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells
Hum. Mol. Genet., July 22, 2000; 9(12): 1729 - 1738.
[Abstract] [Full Text] [PDF]
L. Gerlach, M. Hutson, J. Germiller, D Nguyen-Luu, J. Victor, and K. Barald
Addition of the BMP4 antagonist, noggin, disrupts avian inner ear development
Development, January 1, 2000; 127(1): 45 - 54.
[Abstract] [PDF]
L. A. Everett, H. Morsli, D. K. Wu, and E. D. Green
Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear
PNAS, August 17, 1999; 96(17): 9727 - 9732.
[Abstract] [Full Text] [PDF]
D. Phippard, L. Lu, D. Lee, J. C. Saunders, and E. B. Crenshaw III
Targeted Mutagenesis of the POU-Domain Gene Brn4/Pou3f4 Causes Developmental Defects in the Inner Ear
J. Neurosci., July 15, 1999; 19(14): 5980 - 5989.
[Abstract] [Full Text] [PDF]
H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu
Otx1 and Otx2 activities are required for the normal development of the mouse inner ear
Development, January 6, 1999; 126(11): 2335 - 2343.
[Abstract] [PDF]
D Acampora, V Avantaggiato, F Tuorto, P Barone, M Perera, D Choo, D Wu, G Corte, and A Simeone
Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes
Development, January 4, 1999; 126(7): 1417 - 1426.
[Abstract] [PDF]
P Chen and N Segil
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti
Development, January 4, 1999; 126(8): 1581 - 1590.
[Abstract] [PDF]
J Adam, A Myat, I Le Roux, M Eddison, D Henrique, D Ish-Horowicz, and J Lewis
Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development
Development, January 12, 1998; 125(23): 4645 - 4654.
[Abstract] [PDF]
M Xiang, W. Gao, T Hasson, and J. Shin
Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells
Development, January 10, 1998; 125(20): 3935 - 3946.
[Abstract] [PDF]
A. E. Kiernan, N. Ahituv, H. Fuchs, R. Balling, K. B. Avraham, K. P. Steel, and M. Hrabe de Angelis
The Notch ligand Jagged1 is required for inner ear sensory development
PNAS, March 27, 2001; 98(7): 3873 - 3878.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|