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The Journal of Neuroscience, May 15, 1999, 19(10):3973-3981

Song-Induced Phosphorylation of cAMP Response Element-Binding Protein in the Songbird Brain

Hironobu Sakaguchi^{1, 2}, Kazuhiro Wada³, Masao Maekawa¹, Toshikazu Watsuji³, and Masatoshi Hagiwara³

¹ Department of Physiology, Dokkyo University, School of Medicine, and ² Intelligence and Synthesis, Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, Mibu, Tochigi 321-0293, Japan, and ³ Department of Functional Genomics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan

We have investigated the participation of cAMP response element-binding protein (CREB) in the response of the songbird brain to a natural auditory stimulus, a conspecific song. The cells in the two song control nuclei, the higher vocal center (HVC) and area X of zebra finches (Taeniopygia guttata), were intensely stained with an anti-CREB monoclonal antibody. Double-labeling studies showed that CREB immunoreactivity was detected only in area X-projecting neurons in the HVC. The cloned CREB cDNA from zebra finches (zCREB) is highly homologous to mammalian  CREB. Phosphorylation of zCREB at Ser¹¹⁹ in area X-projecting HVC neurons was induced by hearing tape-recorded conspecific songs of zebra finches, but not by birdsongs of another species or white noise. These results raise the possibility that zCREB plays a crucial role in the sensory process of song learning.

Key words: CREB; birdsong; zebra finch; higher vocal center; phosphorylation; transcription factor

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Copyright © 1999 Society for Neuroscience  0270-6474/99/19103973-09$05.00/0

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