WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Advertisement
 QUICK SEARCH:   [advanced]


     
-


HOME
  |  
SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (325)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Katona, I.
Right arrow Articles by Freund, T. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Katona, I.
Right arrow Articles by Freund, T. F.

 Previous Article  |  Next Article 

The Journal of Neuroscience, June 1, 1999, 19(11):4544-4558

Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

István Katona1, Beáta Sperlágh1, Attila Sík1, Attila Käfalvi1, E. Sylvester Vizi1, Ken Mackie2, and Tamás F. Freund1

1 Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1450, Hungary, and 2 Departments of Anesthesiology, and Physiology and Biophysics, University of Washington, Seattle, Washington 98195

To understand the functional significance and mechanisms of action in the CNS of endogenous and exogenous cannabinoids, it is crucial to identify the neural elements that serve as the structural substrate of these actions. We used a recently developed antibody against the CB1 cannabinoid receptor to study this question in hippocampal networks. Interneurons with features typical of basket cells showed a selective, intense staining for CB1 in all hippocampal subfields and layers. Most of them (85.6%) contained cholecystokinin (CCK), which corresponded to 96.9% of all CCK-positive interneurons, whereas only 4.6% of the parvalbumin (PV)-containing basket cells expressed CB1. Accordingly, electron microscopy revealed that CB1-immunoreactive axon terminals of CCK-containing basket cells surrounded the somata and proximal dendrites of pyramidal neurons, whereas PV-positive basket cell terminals in similar locations were negative for CB1. The synthetic cannabinoid agonist WIN 55,212-2 (0.01-3 µM) reduced dose-dependently the electrical field stimulation-induced [3H]GABA release from superfused hippocampal slices, with an EC50 value of 0.041 µM. Inhibition of GABA release by WIN 55,212-2 was not mediated by inhibition of glutamatergic transmission because the WIN 55,212-2 effect was not reduced by the glutamate blockers AP5 and CNQX. In contrast, the CB1 cannabinoid receptor antagonist SR 141716A (1 µM) prevented this effect, whereas by itself it did not change the outflow of [3H]GABA.

These results suggest that cannabinoid-mediated modulation of hippocampal interneuron networks operate largely via presynaptic receptors on CCK-immunoreactive basket cell terminals. Reduction of GABA release from these terminals is the likely mechanism by which both endogenous and exogenous CB1 ligands interfere with hippocampal network oscillations and associated cognitive functions.

Key words: interneurons; cannabinoids; GABA; inhibition; cholecystokinin; parvalbumin; hippocampus, anxiety


Copyright © 1999 Society for Neuroscience  0270-6474/99/19114544-15$05.00/0


This article has been cited by other articles:


Home page
J. Neurophysiol.Home page
A. Sheinin, G. Talani, M. I. Davis, and D. M. Lovinger
Endocannabinoid- and mGluR5-Dependent Short-Term Synaptic Depression in an Isolated Neuron/Bouton Preparation From the Hippocampal CA1 Region
J Neurophysiol, August 1, 2008; 100(2): 1041 - 1052.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
T. Klausberger and P. Somogyi
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
Science, July 4, 2008; 321(5885): 53 - 57.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
D. A. Edwards, L. Zhang, and B. E. Alger
Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus
PNAS, June 10, 2008; 105(23): 8142 - 8147.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
H. J. Kim, J. J. Waataja, and S. A. Thayer
Cannabinoids Inhibit Network-Driven Synapse Loss between Hippocampal Neurons in Culture
J. Pharmacol. Exp. Ther., June 1, 2008; 325(3): 850 - 858.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
A. Ludanyi, L. Eross, S. Czirjak, J. Vajda, P. Halasz, M. Watanabe, M. Palkovits, Z. Magloczky, T. F. Freund, and I. Katona
Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus
J. Neurosci., March 19, 2008; 28(12): 2976 - 2990.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
L. L. Glickfeld, B. V. Atallah, and M. Scanziani
Complementary Modulation of Somatic Inhibition by Opioids and Cannabinoids
J. Neurosci., February 20, 2008; 28(8): 1824 - 1832.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
B. Pan, C. J. Hillard, and Q.-s. Liu
Endocannabinoid Signaling Mediates Cocaine-Induced Inhibitory Synaptic Plasticity in Midbrain Dopamine Neurons
J. Neurosci., February 6, 2008; 28(6): 1385 - 1397.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Physiol Rev, October 1, 2007; 87(4): 1215 - 1284.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
J. K. Makara, I. Katona, G. Nyiri, B. Nemeth, C. Ledent, M. Watanabe, J. de Vente, T. F. Freund, and N. Hajos
Involvement of Nitric Oxide in Depolarization-Induced Suppression of Inhibition in Hippocampal Pyramidal Cells during Activation of Cholinergic Receptors
J. Neurosci., September 19, 2007; 27(38): 10211 - 10222.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
M.-H. Kang-Park, W. A. Wilson, C. M. Kuhn, S. D. Moore, and H. S. Swartzwelder
Differential Sensitivity of GABAA Receptor-Mediated IPSCs to Cannabinoids in Hippocampal Slices From Adolescent and Adult Rats
J Neurophysiol, September 1, 2007; 98(3): 1223 - 1230.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
E. Carter and X.-J. Wang
Cannabinoid-Mediated Disinhibition and Working Memory: Dynamical Interplay of Multiple Feedback Mechanisms in a Continuous Attractor Model of Prefrontal Cortex
Cereb Cortex, September 1, 2007; 17(suppl_1): i16 - i26.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
A. B. Ali
Presynaptic Inhibition of GABAA Receptor-Mediated Unitary IPSPs by Cannabinoid Receptors at Synapses Between CCK-Positive Interneurons in Rat Hippocampus
J Neurophysiol, August 1, 2007; 98(2): 861 - 869.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
J. J. Tukker, P. Fuentealba, K. Hartwich, P. Somogyi, and T. Klausberger
Cell Type-Specific Tuning of Hippocampal Interneuron Firing during Gamma Oscillations In Vivo
J. Neurosci., August 1, 2007; 27(31): 8184 - 8189.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
E. Szabadits, C. Cserep, A. Ludanyi, I. Katona, J. Gracia-Llanes, T. F. Freund, and G. Nyiri
Hippocampal GABAergic Synapses Possess the Molecular Machinery for Retrograde Nitric Oxide Signaling
J. Neurosci., July 25, 2007; 27(30): 8101 - 8111.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
P. J. Zhu and D. M. Lovinger
Persistent Synaptic Activity Produces Long-Lasting Enhancement of Endocannabinoid Modulation and Alters Long-Term Synaptic Plasticity
J Neurophysiol, June 1, 2007; 97(6): 4386 - 4389.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
H. Huang, C. Acuna-Goycolea, Y. Li, H. M. Cheng, K. Obrietan, and A. N. van den Pol
Cannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal
J. Neurosci., May 2, 2007; 27(18): 4870 - 4881.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
M. Uchigashima, M. Narushima, M. Fukaya, I. Katona, M. Kano, and M. Watanabe
Subcellular Arrangement of Molecules for 2-Arachidonoyl-Glycerol-Mediated Retrograde Signaling and Its Physiological Contribution to Synaptic Modulation in the Striatum
J. Neurosci., April 4, 2007; 27(14): 3663 - 3676.
[Abstract] [Full Text] [PDF]


Home page
NeuroscientistHome page
Y. Hashimotodani, T. Ohno-Shosaku, and M. Kano
Endocannabinoids and Synaptic Function in the CNS
Neuroscientist, April 1, 2007; 13(2): 127 - 137.
[Abstract] [PDF]


Home page
J. Neurophysiol.Home page
E. L. Hill, T. Gallopin, I. Ferezou, B. Cauli, J. Rossier, P. Schweitzer, and B. Lambolez
Functional CB1 Receptors Are Broadly Expressed in Neocortical GABAergic and Glutamatergic Neurons
J Neurophysiol, April 1, 2007; 97(4): 2580 - 2589.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
H. Alle and J. R. P. Geiger
GABAergic Spill-Over Transmission onto Hippocampal Mossy Fiber Boutons
J. Neurosci., January 24, 2007; 27(4): 942 - 950.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
K. Chen, A. Neu, A. L. Howard, C. Foldy, J. Echegoyen, L. Hilgenberg, M. Smith, K. Mackie, and I. Soltesz
Prevention of Plasticity of Endocannabinoid Signaling Inhibits Persistent Limbic Hyperexcitability Caused by Developmental Seizures
J. Neurosci., January 3, 2007; 27(1): 46 - 58.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
D. A. Fortin and E. S. Levine
Differential Effects of Endocannabinoids on Glutamatergic and GABAergic Inputs to Layer 5 Pyramidal Neurons
Cereb Cortex, January 1, 2007; 17(1): 163 - 174.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
S. M. Eggan and D. A. Lewis
Immunocytochemical Distribution of the Cannabinoid CB1 Receptor in the Primate Neocortex: A Regional and Laminar Analysis
Cereb Cortex, January 1, 2007; 17(1): 175 - 191.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
A. Neu, C. Foldy, and I. Soltesz
Postsynaptic origin of CB1-dependent tonic inhibition of GABA release at cholecystokinin-positive basket cell to pyramidal cell synapses in the CA1 region of the rat hippocampus
J. Physiol., January 1, 2007; 578(1): 233 - 247.
[Abstract] [Full Text] [PDF]


Home page
Learn. Mem.Home page
A. F. Hoffman, M. Oz, R. Yang, A. H. Lichtman, and C. R. Lupica
Opposing actions of chronic {Delta}9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
Learn. Mem., January 1, 2007; 14(1-2): 63 - 74.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
A. A. Biro, N. B. Holderith, and Z. Nusser
Release Probability-Dependent Scaling of the Postsynaptic Responses at Single Hippocampal GABAergic Synapses
J. Neurosci., November 29, 2006; 26(48): 12487 - 12496.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
M. E. Hofmann, B. Nahir, and C. J. Frazier
Endocannabinoid-Mediated Depolarization-Induced Suppression of Inhibition in Hilar Mossy Cells of the Rat Dentate Gyrus
J Neurophysiol, November 1, 2006; 96(5): 2501 - 2512.
[Abstract] [Full Text] [PDF]


Home page
Am. J. PsychiatryHome page
P. D. Skosnik, G. P. Krishnan, E. E. Aydt, H. A. Kuhlenshmidt, and B. F. O'Donnell
Psychophysiological Evidence of Altered Neural Synchronization in Cannabis Use: Relationship to Schizotypy
Am J Psychiatry, October 1, 2006; 163(10): 1798 - 1805.
[Abstract] [Full Text] [PDF]


Home page
Pharmacol. Rev.Home page
P. Pacher, S. Batkai, and G. Kunos
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pharmacol. Rev., September 1, 2006; 58(3): 389 - 462.
[Abstract] [Full Text] [PDF]


Home page
Pharmacol. Rev.Home page
M. Raiteri
Functional pharmacology in human brain.
Pharmacol. Rev., June 1, 2006; 58(2): 162 - 193.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
I. Katona, G. M. Urban, M. Wallace, C. Ledent, K.-M. Jung, D. Piomelli, K. Mackie, and T. F. Freund
Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses
J. Neurosci., May 24, 2006; 26(21): 5628 - 5637.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
M. R. Domenici, S. C. Azad, G. Marsicano, A. Schierloh, C. T. Wotjak, H.-U. Dodt, W. Zieglgansberger, B. Lutz, and G. Rammes
Cannabinoid Receptor Type 1 Located on Presynaptic Terminals of Principal Neurons in the Forebrain Controls Glutamatergic Synaptic Transmission
J. Neurosci., May 24, 2006; 26(21): 5794 - 5799.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
T. Yoshida, M. Fukaya, M. Uchigashima, E. Miura, H. Kamiya, M. Kano, and M. Watanabe
Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor.
J. Neurosci., May 3, 2006; 26(18): 4740 - 4751.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
C. Leterrier, J. Laine, M. Darmon, H. Boudin, J. Rossier, and Z. Lenkei
Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors.
J. Neurosci., March 22, 2006; 26(12): 3141 - 3153.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
Y. Kawamura, M. Fukaya, T. Maejima, T. Yoshida, E. Miura, M. Watanabe, T. Ohno-Shosaku, and M. Kano
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum.
J. Neurosci., March 15, 2006; 26(11): 2991 - 3001.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
U. Pagotto, G. Marsicano, D. Cota, B. Lutz, and R. Pasquali
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
Endocr. Rev., February 1, 2006; 27(1): 73 - 100.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
C. Foldy, A. Neu, M. V. Jones, and I. Soltesz
Presynaptic, Activity-Dependent Modulation of Cannabinoid Type 1 Receptor-Mediated Inhibition of GABA Release
J. Neurosci., February 1, 2006; 26(5): 1465 - 1469.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
P. Berghuis, M. B. Dobszay, X. Wang, S. Spano, F. Ledda, K. M. Sousa, G. Schulte, P. Ernfors, K. Mackie, G. Paratcha, et al.
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
PNAS, December 27, 2005; 102(52): 19115 - 19120.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
T. Klausberger, L. F. Marton, J. O'Neill, J. H. J. Huck, Y. Dalezios, P. Fuentealba, W. Y. Suen, E. Papp, T. Kaneko, M. Watanabe, et al.
Complementary Roles of Cholecystokinin- and Parvalbumin-Expressing GABAergic Neurons in Hippocampal Network Oscillations
J. Neurosci., October 19, 2005; 25(42): 9782 - 9793.
[Abstract] [Full Text] [PDF]


Home page
NeuroscientistHome page
Y. Zilberter, T. Harkany, and C. D. Holmgren
Dendritic Release of Retrograde Messengers Controls Synaptic Transmission in Local Neocortical Networks
Neuroscientist, August 1, 2005; 11(4): 334 - 344.
[Abstract] [PDF]


Home page
J. Neurosci.Home page
A. L. Bodor, I. Katona, G. Nyiri, K. Mackie, C. Ledent, N. Hajos, and T. F. Freund
Endocannabinoid Signaling in Rat Somatosensory Cortex: Laminar Differences and Involvement of Specific Interneuron Types
J. Neurosci., July 20, 2005; 25(29): 6845 - 6856.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
C. Bernard, M. Milh, Y. M. Morozov, Y. Ben-Ari, T. F. Freund, and H. Gozlan
Altering cannabinoid signaling during development disrupts neuronal activity
PNAS, June 28, 2005; 102(26): 9388 - 9393.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
A. Kofalvi, R. J. Rodrigues, C. Ledent, K. Mackie, E. S. Vizi, R. A. Cunha, and B. Sperlagh
Involvement of Cannabinoid Receptors in the Regulation of Neurotransmitter Release in the Rodent Striatum: A Combined Immunochemical and Pharmacological Analysis
J. Neurosci., March 16, 2005; 25(11): 2874 - 2884.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
P. Somogyi and T. Klausberger
Defined types of cortical interneurone structure space and spike timing in the hippocampus
J. Physiol., January 1, 2005; 562(1): 9 - 26.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
C. Foldy, J. Dyhrfjeld-Johnsen, and I. Soltesz
Structure of cortical microcircuit theory
J. Physiol., January 1, 2005; 562(1): 47 - 54.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
M. Galarreta, F. Erdelyi, G. Szabo, and S. Hestrin
Electrical Coupling among Irregular-Spiking GABAergic Interneurons Expressing Cannabinoid Receptors
J. Neurosci., November 3, 2004; 24(44): 9770 - 9778.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
D. A. Fortin, J. Trettel, and E. S. Levine
Brief Trains of Action Potentials Enhance Pyramidal Neuron Excitability Via Endocannabinoid-Mediated Suppression of Inhibition
J Neurophysiol, October 1, 2004; 92(4): 2105 - 2112.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
A. V. Derbenev, T. C. Stuart, and B. N. Smith
Cannabinoids suppress synaptic input to neurones of the rat dorsal motor nucleus of the vagus nerve
J. Physiol., September 15, 2004; 559(3): 923 - 938.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
D. A. Rusakov, A. Wuerz, and D. M. Kullmann
Heterogeneity and Specificity of Presynaptic Ca2+ Current Modulation by mGluRs at Individual Hippocampal Synapses
Cereb Cortex, July 1, 2004; 14(7): 748 - 758.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
S. P. Brown, P. K. Safo, and W. G. Regehr
Endocannabinoids Inhibit Transmission at Granule Cell to Purkinje Cell Synapses by Modulating Three Types of Presynaptic Calcium Channels
J. Neurosci., June 16, 2004; 24(24): 5623 - 5631.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
T. Harkany, C. Holmgren, W. Hartig, T. Qureshi, F. A. Chaudhry, J. Storm-Mathisen, M. B. Dobszay, P. Berghuis, G. Schulte, K. M. Sousa, et al.
Endocannabinoid-Independent Retrograde Signaling at Inhibitory Synapses in Layer 2/3 of Neocortex: Involvement of Vesicular Glutamate Transporter 3
J. Neurosci., May 26, 2004; 24(21): 4978 - 4988.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
M. Galante and M. A. Diana
Group I Metabotropic Glutamate Receptors Inhibit GABA Release at Interneuron-Purkinje Cell Synapses through Endocannabinoid Production
J. Neurosci., May 19, 2004; 24(20): 4865 - 4874.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
J. Trettel, D. A. Fortin, and E. S. Levine
Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex
J. Physiol., April 1, 2004; 556(1): 95 - 107.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
A. Losonczy, A. A. Biro, and Z. Nusser
Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneurons
PNAS, February 3, 2004; 101(5): 1362 - 1367.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
N. G. Bazan
Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor
J. Lipid Res., December 1, 2003; 44(12): 2221 - 2233.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
L. Yao, P. Fan, Z. Jiang, W. S. Mailliard, A. S. Gordon, and I. Diamond
Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-{beta}{gamma} dimers
PNAS, November 25, 2003; 100(24): 14379 - 14384.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
G. Marsicano, S. Goodenough, K. Monory, H. Hermann, M. Eder, A. Cannich, S. C. Azad, M. G. Cascio, S. O. Gutierrez, M. van der Stelt, et al.
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
Science, October 3, 2003; 302(5642): 84 - 88.
[Abstract] [Full Text] [PDF]