QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Serpe, C. J. Articles by Jones, K. J. Search for Related Content PubMed PubMed Citation Articles by Serpe, C. J. Articles by Jones, K. J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, 1999:RC7:1-5

RAPID COMMUNICATION
Exacerbation of Facial Motoneuron Loss after Facial Nerve Transection in Severe Combined Immunodeficient (scid) Mice

Craig J. Serpe^{1, 3}, Adam P. Kohm¹, Christopher B. Huppenbauer^{1, 3}, Virginia M. Sanders^{1, 2}, and Kathryn J. Jones^{1, 3}

Departments of ¹ Cell Biology, Neurobiology, and Anatomy and ² Microbiology and Immunology, Loyola University Medical Center, Illinois 60153, ³ Department of Rehabilitation, Research and Development, Hines Veterans Administration Hospital, Hines, Illinois 60141

The immune system functions to protect an organism against microbial infections and may be involved in the reparative response to nerve injury. The goal of this study was to determine whether the immune system plays a role in regulating motoneuron survival after a peripheral nerve injury. After a right facial nerve axotomy, facial motoneuron (FMN) survival in C.B-17 (+/+) wild-type mice was found to be 87 ± 3.0% of the unaxotomized left side control. In contrast, facial nerve axotomy in C.B-17 (/) severe combined immunodeficient (scid) mice, lacking functional T and B lymphocytes, resulted in an average FMN survival of 55 ± 3.5% relative to the unaxotomized left side control. This represented an ~40% decrease in FMN survival compared with wild-type controls. The reconstitution of scid mice with wild-type splenocytes containing T and B lymphocytes restored FMN survival in these mice to the level of the wild-type controls. These results suggest that immune cells associated with acquired immunity play a role in regulating motoneuron survival after a peripheral nerve injury.

Key words: scid; T and B Lymphocytes; neuroimmune interactions; FMN; acquired immunity; reconstitution

---

Copyright © 1999 Society for Neuroscience  0270-6474/99/$05.00/0

This article has been cited by other articles:

				A. Brunn, O. Utermohlen, M. Carstov, M. S. Ruiz, H. Miletic, D. Schluter, and M. Deckert CD4 T Cells Mediate Axonal Damage and Spinal Cord Motor Neuron Apoptosis in Murine P0106-125-Induced Experimental Autoimmune Neuritis Am. J. Pathol., July 1, 2008; 173(1): 93 - 105. [Abstract] [Full Text] [PDF]

				C. W. Ip, A. Kroner, M. Bendszus, C. Leder, I. Kobsar, S. Fischer, H. Wiendl, K.-A. Nave, and R. Martini Immune Cells Contribute to Myelin Degeneration and Axonopathic Changes in Mice Overexpressing Proteolipid Protein in Oligodendrocytes J. Neurosci., August 2, 2006; 26(31): 8206 - 8216. [Abstract] [Full Text] [PDF]

				C. Ling, M. Sandor, M. Suresh, and Z. Fabry Traumatic Injury and the Presence of Antigen Differentially Contribute to T-Cell Recruitment in the CNS J. Neurosci., January 18, 2006; 26(3): 731 - 741. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help