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Previous Article | Next Article
The Journal of Neuroscience, June 15, 1999, 19(12):4772-4777
Regulation of the UNC-18-Caenorhabditis elegans Syntaxin Complex by UNC-13
Toshihiro Sassa1, Shin-ichi Harada2, Hisamitu Ogawa4, James B. Rand5, Ichiro N. Maruyama6, and Ryuji Hosono3 1 Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-0042, Japan, 2 Center for Biomedical Research and Education and 3 Department of Physical Information, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan, 4 Department of Biology, Fujita Health University, Aichi 470-1192, Japan, 5 Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, and 6 Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037
The Caenorhabditis elegans unc-13, unc-18, and unc-64 genes are required for normal synaptic transmission. The UNC-18 protein binds to the unc-64 gene product C. elegans syntaxin (Ce syntaxin). However, it is not clear how this protein complex is regulated. We show that UNC-13 transiently interacts with the UNC-18-Ce syntaxin complex, resulting in rapid displacement of UNC-18 from the complex. Genetic and biochemical evidence is presented that UNC-13 contributes to the modulation of the interaction between UNC-18 and Ce syntaxin.
Key words: UNC-18; Ce syntaxin; UNC-13; SNARE complex; synaptic vesicle; exocytosis
Copyright © 1999 Society for Neuroscience 0270-6474/99/19124772-06$05.00/0
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