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The Journal of Neuroscience, June 15, 1999, 19(12):5119-5123

Basolateral Amygdala Noradrenergic Influences on Memory Storage Are Mediated by an Interaction between - and ₁-Adrenoceptors

Barbara Ferry, Benno Roozendaal, and James L. McGaugh

Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697-3800

Extensive evidence indicates that norepinephrine modulates memory storage through an activation of -adrenoceptors in the basolateral nucleus of the amygdala (BLA). Recent findings suggest that the effects of -adrenergic activation on memory storage are influenced by ₁-adrenoceptor stimulation. Pharmacological findings indicate that activation of postsynaptic ₁-adrenoceptors potentiates -adrenoceptor-mediated activation of cAMP formation. The present study examined whether inactivation of ₁-adrenoceptors in the BLA would alter the dose-response effects on memory storage of intra-BLA infusions of a -adrenoceptor agonist, as well as that of a synthetic cAMP analog. Male Sprague Dawley rats received bilateral microinfusions into the BLA of either the -adrenoceptor agonist clenbuterol (3-3000 pmol in 0.2 µl) or 8-bromoadenosine 3':5'-cyclic monophosphate (8-bromo-cAMP) (0.2-7 nmol in 0.2 µl) alone or together with the ₁-adrenoceptor antagonist prazosin (0.2 nmol) immediately after training in an inhibitory avoidance task. Retention was tested 48 hr later. Clenbuterol induced a dose-dependent enhancement of retention, and prazosin attenuated the dose-response effects of clenbuterol. Posttraining intra-BLA infusions of 8-bromo-cAMP also induced a dose-dependent enhancement of retention latencies. However, concurrent infusion of prazosin did not alter the dose-response effects of 8-bromo-cAMP. These findings are consistent with the view that ₁-adrenoceptors affect memory storage by modulating -adrenoceptor activation in the BLA. Moreover, these findings are consistent with those of pharmacological studies indicating that -adrenoceptors modulate memory storage by a direct coupling to adenylate cyclase, whereas ₁-receptors act indirectly by influencing the -adrenoceptor-mediated influence on cAMP formation.

Key words: basolateral amygdala; ₁-adrenoceptor; -adrenoceptor; norepinephrine; memory storage; cAMP

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Copyright © 1999 Society for Neuroscience  0270-6474/99/19125119-05$05.00/0

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