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The Journal of Neuroscience, 1999, 0:RC12:1-8

RAPID COMMUNICATION
GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei

J. Hikke van Doorninck¹, Jacqueline van der Wees¹, Alar Karis^{1, 3}, Erika Goedknegt², J. Douglas Engel⁴, Michiel Coesmans², Mandy Rutteman^{1, 2}, Frank Grosveld¹, and Chris I. De Zeeuw²

Departments of ¹ Cell Biology and Genetics and ² Anatomy, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands, ³ Institute of Molecular and Cell Biology, Tartu University, EE2400 Tartu, Estonia, and ⁴ Department of Biochemistry and Molecular Biology, Northwestern University, Chicago, Illinois 60611

The GATA-3 transcription factor shows a specific and restricted expression pattern in the developing and adult mouse brain. In the present study we investigated the role of GATA-3 in the caudal raphe system, which is known to operate as a modulator of motor activity. We demonstrate that virtually all neurons in the caudal raphe nuclei that express GATA-3 also produce serotonin. Absence of GATA-3, as analyzed in chimeric / mice, affects the cytoarchitecture of serotonergic neurons in the caudal raphe nuclei. As a result the chimeras show a serious defect in their locomotor performance on a rotating rod. In sum, we conclude that GATA-3 plays a major role in the development of the serotonergic neurons of the caudal raphe nuclei, and that it is crucial for their role in locomotion.

Key words: locomotion; rotorod; transcription factors; (tau-)lacZ; nucleus raphes obscurus; nucleus raphes pallidus; rhombomere 4

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Copyright © 1999 Society for Neuroscience  0270-6474/99/$05.00/0

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