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The Journal of Neuroscience, July 1, 1999, 19(13):5493-5505
Prospective Coding for Objects in Primate Prefrontal Cortex
Gregor
Rainer,
S. Chenchal
Rao, and
Earl K.
Miller
Department of Brain and Cognitive Sciences, Center for Learning and
Memory, and RIKEN-MIT Neuroscience Center, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139
We examined neural activity in prefrontal (PF) cortex of monkeys
performing a delayed paired associate task. Monkeys were cued
with a sample object. Then, after a delay, a test object was presented.
If the test object was the object associated with the sample during
training (i.e., its target), they had to release a lever. Monkeys could
bridge the delay by remembering the sample (a sensory-related code)
and/or thinking ahead to the expected target (a prospective code).
Examination of the monkeys' behavior suggested that they were relying
on a prospective code. During and shortly after sample presentation,
neural activity in the lateral PF cortex primarily reflected the
sample. Toward the end of the delay, however, PF activity began to
reflect the anticipated target, which indicated a prospective code.
These results provide further confirmation that PF cortex does not
simply buffer incoming visual inputs, but instead selectively processes
information relevant to current behavioral demands, even when this
information must be recalled from long-term memory.
Key words:
prefrontal cortex; pair association; working memory; associative memory; physiology; vision; long-term memory; recall; monkey
Copyright © 1999 Society for Neuroscience 0270-6474/99/19135493-13$05.00/0
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