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Previous Article | Next Article
The Journal of Neuroscience, July 15, 1999, 19(14):5847-5860
The Stoned Proteins Regulate Synaptic Vesicle Recycling in the Presynaptic Terminal
Tim Fergestad, Warren S. Davis, and Kendal Broadie Department of Biology, University of Utah, Salt Lake City, Utah 84112
The Drosophila stoned locus was identified 25 years ago on the basis of stress-sensitive behavioral mutants (Grigliatti et al., 1973). The locus is dicistronic and encodes two distinct proteins, stoned A and stoned B, which are expressed specifically in presynaptic terminals at central and peripheral synapses. Several stoned mutant alleles cause embryonic lethality, suggesting that these proteins are essential for synaptic function. Physiological analyses at the stoned synapse reveal severe neurotransmission defects, including reduced and asynchronous neurotransmitter release and rapid fatigue after repetitive stimulation. At the EM level, stoned synapses show a depletion of synaptic vesicles and a concomitant increase in membrane-recycling intermediates. Mutant terminals also display a specific mislocalization of the synaptic vesicle protein synaptotagmin. These results suggest that the stoned proteins are essential for the recycling of synaptic vesicle membrane and are required for the proper sorting of synaptotagmin during endocytosis.
Key words: Drosophila; neuromuscular junction; synapse; stoned; synaptotagmin; endocytosis
Copyright © 1999 Society for Neuroscience 0270-6474/99/19145847-14$05.00/0
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