 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, August 1, 1999, 19(15):6610-6614
Orbitofrontal Cortex and Representation of Incentive Value in Associative Learning
Michela Gallagher, Robert W. McMahan, and Geoffrey Schoenbaum Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218
Clinical evidence indicates that damage to ventromedial prefrontal cortex disrupts goal-directed actions that are guided by motivational and emotional factors. As a consequence, patients with such damage characteristically engage in maladaptive behaviors. Other research has shown that neurons in the corresponding orbital region of prefrontal cortex in laboratory animals encode information regarding the incentive properties of goals or expected events. The present study investigates the effect of neurotoxic orbitofrontal cortex (OFC) lesions in the rat on responses that are normally influenced by associations between a conditioned stimulus (CS) and the incentive value of reinforcement. Rats were first trained to associate a visual CS with delivery of food pellets to a food cup. As a consequence of learning, rats approached the food cup during the CS in anticipation of reinforcement. In a second training phase, injection of LiCl followed consumption of the food unconditioned stimulus (US) in the home cage, a procedure used to alter the incentive value of the US. Subsequently, rats were returned to the conditioning chamber, and their responding to the CS in the absence of the food US was tested. Lesions of OFC did not affect either the initial acquisition of a conditioned response to the light CS in the first training phase or taste aversion learning in the second training phase. In the test for devaluation, however, OFC rats exhibited no change in conditioned responding to the visual CS. This outcome contrasts with the behavior of control rats; after devaluation of the US a significant decrease occurred in approach to the food cup during presentation of the CS. The results reveal an inability of a cue to access representational information about the incentive value of associated reinforcement after OFC damage.
Key words: orbitofrontal; devaluation; goal neglect; prefrontal; associative learning; agranular insular
Copyright © 1999 Society for Neuroscience 0270-6474/99/19156610-05$05.00/0
This article has been cited by other articles:
C. Padoa-Schioppa
Range-Adapting Representation of Economic Value in the Orbitofrontal Cortex
J. Neurosci., November 4, 2009; 29(44): 14004 - 14014.
[Abstract] [Full Text] [PDF]
M. R. Roesch, T. Singh, P. L. Brown, S. E. Mullins, and G. Schoenbaum
Ventral Striatal Neurons Encode the Value of the Chosen Action in Rats Deciding between Differently Delayed or Sized Rewards
J. Neurosci., October 21, 2009; 29(42): 13365 - 13376.
[Abstract] [Full Text] [PDF]
V. S. Chib, A. Rangel, S. Shimojo, and J. P. O'Doherty
Evidence for a Common Representation of Decision Values for Dissimilar Goods in Human Ventromedial Prefrontal Cortex
J. Neurosci., September 30, 2009; 29(39): 12315 - 12320.
[Abstract] [Full Text] [PDF]
M. McDannald and G. Schoenbaum
Toward a Model of Impaired Reality Testing in Rats
Schizophr Bull, July 1, 2009; 35(4): 664 - 667.
[Abstract] [Full Text] [PDF]
M.S. Man, H.F. Clarke, and A.C. Roberts
The Role of the Orbitofrontal Cortex and Medial Striatum in the Regulation of Prepotent Responses to Food Rewards
Cereb Cortex, April 1, 2009; 19(4): 899 - 906.
[Abstract] [Full Text] [PDF]
S.C. Walker, T.W. Robbins, and A.C. Roberts
Differential Contributions of Dopamine and Serotonin to Orbitofrontal Cortex Function in the Marmoset
Cereb Cortex, April 1, 2009; 19(4): 889 - 898.
[Abstract] [Full Text] [PDF]
E. van Duuren, J. Lankelma, and C. M. A. Pennartz
Population Coding of Reward Magnitude in the Orbitofrontal Cortex of the Rat
J. Neurosci., August 20, 2008; 28(34): 8590 - 8603.
[Abstract] [Full Text] [PDF]
P. C. HOLLAND
Cognitive versus stimulus-response theories of learning
Learn Behav, August 1, 2008; 36(3): 227 - 241.
[Abstract] [PDF]
T. Furuyashiki, P. C. Holland, and M. Gallagher
Rat Orbitofrontal Cortex Separately Encodes Response and Outcome Information during Performance of Goal-Directed Behavior
J. Neurosci., May 7, 2008; 28(19): 5127 - 5138.
[Abstract] [Full Text] [PDF]
E. C. Kerfoot, I. Agarwal, H. J. Lee, and P. C. Holland
Control of appetitive and aversive taste-reactivity responses by an auditory conditioned stimulus in a devaluation task: A FOS and behavioral analysis
Learn. Mem., August 29, 2007; 14(9): 581 - 589.
[Abstract] [Full Text] [PDF]
E. A. Murray, J. P. O'Doherty, and G. Schoenbaum
What We Know and Do Not Know about the Functions of the Orbitofrontal Cortex after 20 Years of Cross-Species Studies
J. Neurosci., August 1, 2007; 27(31): 8166 - 8169.
[Abstract] [Full Text] [PDF]
M. Gil, R. J. De Marco, and R. Menzel
Learning reward expectations in honeybees
Learn. Mem., July 12, 2007; 14(7): 491 - 496.
[Abstract] [Full Text] [PDF]
E. van Duuren, F. A. N. Escamez, R. N.J.M.A. Joosten, R. Visser, A. B. Mulder, and C. M.A. Pennartz
Neural coding of reward magnitude in the orbitofrontal cortex of the rat during a five-odor olfactory discrimination task
Learn. Mem., June 11, 2007; 14(6): 446 - 456.
[Abstract] [Full Text] [PDF]
R.J Dolan
The human amygdala and orbital prefrontal cortex in behavioural regulation
Phil Trans R Soc B, May 29, 2007; 362(1481): 787 - 799.
[Abstract] [Full Text] [PDF]
S. B. Ostlund and B. W. Balleine
Orbitofrontal Cortex Mediates Outcome Encoding in Pavlovian But Not Instrumental Conditioning
J. Neurosci., May 2, 2007; 27(18): 4819 - 4825.
[Abstract] [Full Text] [PDF]
Y Chudasama, J. Kralik, and E. Murray
Rhesus Monkeys with Orbital Prefrontal Cortex Lesions Can Learn to Inhibit Prepotent Responses in the Reversed Reward Contingency Task
Cereb Cortex, May 1, 2007; 17(5): 1154 - 1159.
[Abstract] [Full Text] [PDF]
S. Pecina, K. S. Smith, and K. C. Berridge
Hedonic Hot Spots in the Brain
Neuroscientist, December 1, 2006; 12(6): 500 - 511.
[Abstract] [PDF]
A. Izquierdo, R. K. Suda, and E. A. Murray
Comparison of the Effects of Bilateral Orbital Prefrontal Cortex Lesions and Amygdala Lesions on Emotional Responses in Rhesus Monkeys
J. Neurosci., September 14, 2005; 25(37): 8534 - 8542.
[Abstract] [Full Text] [PDF]
S. B. Ostlund and B. W. Balleine
Lesions of Medial Prefrontal Cortex Disrupt the Acquisition But Not the Expression of Goal-Directed Learning
J. Neurosci., August 24, 2005; 25(34): 7763 - 7770.
[Abstract] [Full Text] [PDF]
G. Schoenbaum and B. Setlow
Cocaine Makes Actions Insensitive to Outcomes but not Extinction: Implications for Altered Orbitofrontal-Amygdalar Function
Cereb Cortex, August 1, 2005; 15(8): 1162 - 1169.
[Abstract] [Full Text] [PDF]
M. A. McDannald, M. P. Saddoris, M. Gallagher, and P. C. Holland
Lesions of Orbitofrontal Cortex Impair Rats' Differential Outcome Expectancy Learning But Not Conditioned Stimulus-Potentiated Feeding
J. Neurosci., May 4, 2005; 25(18): 4626 - 4632.
[Abstract] [Full Text] [PDF]
F. Roullet, F. Lienard, F. Datiche, and M. Cattarelli
Fos protein expression in olfactory-related brain areas after learning and after reactivation of a slowly acquired olfactory discrimination task in the rat
Learn. Mem., May 1, 2005; 12(3): 307 - 317.
[Abstract] [Full Text] [PDF]
S. M. L. Cox, A. Andrade, and I. S. Johnsrude
Learning to Like: A Role for Human Orbitofrontal Cortex in Conditioned Reward
J. Neurosci., March 9, 2005; 25(10): 2733 - 2740.
[Abstract] [Full Text] [PDF]
A. W. Johnson, D. M. Bannerman, N. P. Rawlins, R. Sprengel, and M. A. Good
Impaired Outcome-Specific Devaluation of Instrumental Responding in Mice with a Targeted Deletion of the AMPA Receptor Glutamate Receptor 1 Subunit
J. Neurosci., March 2, 2005; 25(9): 2359 - 2365.
[Abstract] [Full Text] [PDF]
H. S. Crombag, G. Gorny, Y. Li, B. Kolb, and T. E. Robinson
Opposite Effects of Amphetamine Self-administration Experience on Dendritic Spines in the Medial and Orbital Prefrontal Cortex
Cereb Cortex, March 1, 2005; 15(3): 341 - 348.
[Abstract] [Full Text] [PDF]
R. A. Fuchs, K. A. Evans, M. P. Parker, and R. E. See
Differential Involvement of Orbitofrontal Cortex Subregions in Conditioned Cue-Induced and Cocaine-Primed Reinstatement of Cocaine Seeking in Rats
J. Neurosci., July 21, 2004; 24(29): 6600 - 6610.
[Abstract] [Full Text] [PDF]
G. Schoenbaum
Affect, Action, and Ambiguity and the Amygdala-Orbitofrontal Circuit. Focus on "Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys"
J Neurophysiol, May 1, 2004; 91(5): 1938 - 1939.
[Full Text] [PDF]
A. Izquierdo and E. A. Murray
Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys
J Neurophysiol, May 1, 2004; 91(5): 2023 - 2039.
[Abstract] [Full Text] [PDF]
S. Datta, V. Mavanji, J. Ulloor, and E. H. Patterson
Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity
J. Neurosci., February 11, 2004; 24(6): 1416 - 1427.
[Abstract] [Full Text] [PDF]
I. K. Goerendt, A. D. Lawrence, and D. J. Brooks
Reward Processing in Health and Parkinson's Disease: Neural Organization and Reorganization
Cereb Cortex, January 1, 2004; 14(1): 73 - 80.
[Abstract] [Full Text] [PDF]
C. L. Pickens, M. P. Saddoris, B. Setlow, M. Gallagher, P. C. Holland, and G. Schoenbaum
Different Roles for Orbitofrontal Cortex and Basolateral Amygdala in a Reinforcer Devaluation Task
J. Neurosci., December 3, 2003; 23(35): 11078 - 11084.
[Abstract] [Full Text] [PDF]
A. Pears, J. A. Parkinson, L. Hopewell, B. J. Everitt, and A. C. Roberts
Lesions of the Orbitofrontal but not Medial Prefrontal Cortex Disrupt Conditioned Reinforcement in Primates
J. Neurosci., December 3, 2003; 23(35): 11189 - 11201.
[Abstract] [Full Text] [PDF]
G. Schoenbaum and B. Setlow
Lesions of Nucleus Accumbens Disrupt Learning about Aversive Outcomes
J. Neurosci., October 29, 2003; 23(30): 9833 - 9841.
[Abstract] [Full Text] [PDF]
J. A. Gottfried, J. O'Doherty, and R. J. Dolan
Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex
Science, August 22, 2003; 301(5636): 1104 - 1107.
[Abstract] [Full Text] [PDF]
P. Blundell, G. Hall, and S. Killcross
Preserved Sensitivity to Outcome Value after Lesions of the Basolateral Amygdala
J. Neurosci., August 20, 2003; 23(20): 7702 - 7709.
[Abstract] [Full Text] [PDF]
H. C. Cromwell and W. Schultz
Effects of Expectations for Different Reward Magnitudes on Neuronal Activity in Primate Striatum
J Neurophysiol, May 1, 2003; 89(5): 2823 - 2838.
[Abstract] [Full Text] [PDF]
I. Bohn, C. Giertler, and W. Hauber
Orbital Prefrontal Cortex and Guidance of Instrumental Behavior of Rats by Visuospatial Stimuli Predicting Reward Magnitude
Learn. Mem., May 1, 2003; 10(3): 177 - 186.
[Abstract] [Full Text] [PDF]
S. Killcross and E. Coutureau
Coordination of Actions and Habits in the Medial Prefrontal Cortex of Rats
Cereb Cortex, April 1, 2003; 13(4): 400 - 408.
[Abstract] [Full Text] [PDF]
G. Schoenbaum, B. Setlow, S. L. Nugent, M. P. Saddoris, and M. Gallagher
Lesions of Orbitofrontal Cortex and Basolateral Amygdala Complex Disrupt Acquisition of Odor-Guided Discriminations and Reversals
Learn. Mem., March 1, 2003; 10(2): 129 - 140.
[Abstract] [Full Text] [PDF]
A. N. Mead and D. N. Stephens
Selective Disruption of Stimulus-Reward Learning in Glutamate Receptor gria1 Knock-Out Mice
J. Neurosci., February 1, 2003; 23(3): 1041 - 1048.
[Abstract] [Full Text] [PDF]
B. W. Balleine, A. S. Killcross, and A. Dickinson
The Effect of Lesions of the Basolateral Amygdala on Instrumental Conditioning
J. Neurosci., January 15, 2003; 23(2): 666 - 675.
[Abstract] [Full Text] [PDF]
D. M. Small, R. J. Zatorre, A. Dagher, A. C. Evans, and M. Jones-Gotman
Changes in brain activity related to eating chocolate: From pleasure to aversion
Brain, September 1, 2001; 124(9): 1720 - 1733.
[Abstract] [Full Text] [PDF]
G. Schoenbaum and B. Setlow
Integrating Orbitofrontal Cortex into Prefrontal Theory: Common Processing Themes across Species and Subdivisions
Learn. Mem., May 1, 2001; 8(3): 134 - 147.
[Abstract] [Full Text] [PDF]
C. R. Savage, T. Deckersbach, S. Heckers, A. D. Wagner, D. L. Schacter, N. M. Alpert, A. J. Fischman, and S. L. Rauch
Prefrontal regions supporting spontaneous and directed application of verbal learning strategies: Evidence from PET
Brain, January 1, 2001; 124(1): 219 - 231.
[Abstract] [Full Text] [PDF]
S. Datta
Avoidance Task Training Potentiates Phasic Pontine-Wave Density in the Rat: A Mechanism for Sleep-Dependent Plasticity
J. Neurosci., November 15, 2000; 20(22): 8607 - 8613.
[Abstract] [Full Text] [PDF]
W. Hauber, I. Bohn, and C. Giertler
NMDA, But Not Dopamine D2, Receptors in the Rat Nucleus Accumbens Are Involved in Guidance of Instrumental Behavior by Stimuli Predicting Reward Magnitude
J. Neurosci., August 15, 2000; 20(16): 6282 - 6288.
[Abstract] [Full Text] [PDF]
G. Schoenbaum, A. A. Chiba, and M. Gallagher
Changes in Functional Connectivity in Orbitofrontal Cortex and Basolateral Amygdala during Learning and Reversal Training
J. Neurosci., July 1, 2000; 20(13): 5179 - 5189.
[Abstract] [Full Text] [PDF]
M. G. Baxter, A. Parker, C. C. C. Lindner, A. D. Izquierdo, and E. A. Murray
Control of Response Selection by Reinforcer Value Requires Interaction of Amygdala and Orbital Prefrontal Cortex
J. Neurosci., June 1, 2000; 20(11): 4311 - 4319.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|