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The Journal of Neuroscience, August 15, 1999, 19(16):6767-6773

Transistor Probes Local Potassium Conductances in the Adhesion Region of Cultured Rat Hippocampal Neurons

Stefano Vassanelli and Peter Fromherz

Department of Membrane and Neurophysics, Max-Planck-Institute for Biochemistry, D-82152 Martinsried/München, Germany

Adhesion interactions of neurons in a tissue may affect the ion conductance of the plasma membrane, inducing selective localization and modulation of channels. We studied the adhesion region of cultured neurons from rat hippocampus as a defined model where such effects could be observed electrophysiologically, taking advantage of extracellular recording by a transistor integrated in the substrate. We observed the K+ current through the region of soma adhesion under voltage-clamp and compared it with the current through the whole cell. We found that the specific A-type conductance was depleted, even completely, in the region of adhesion, whereas the specific K-type conductance was enhanced up to a factor of 12. The electrophysiological approach opens a new way to investigate targeting of ion channels in the cell membrane as a function of adhesion processes.

Key words: transistor; potassium; conductance; channel, localization; A-type; K-type; adhesion

Copyright © 1999 Society for Neuroscience  0270-6474/99/19166767-07$05.00/0


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