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The Journal of Neuroscience, January 15, 1999, 19(2):599-609
Subthalamic Nucleus Neurons Switch from Single-Spike Activity to Burst-Firing Mode
Corinne Beurrier1, Patrice Congar2, Bernard Bioulac1, and Constance Hammond3 1 Université de Bordeaux II, Centre National de la Recherche Scientifique Unitié Mixte de Recherche 5543, 33076 Bordeaux cédex, France, 2 Université René Descartes, Institut National de la Santé et de la Recherche Médicale U 29, 75674 Paris cédex 14, France, and 3 Centre Paul Broca, Institut National de la Santé et de la Recherche Médicale U 159, 75014 Paris, France
The modification of the discharge pattern of subthalamic nucleus (STN) neurons from single-spike activity to mixed burst-firing mode is one of the characteristics of parkinsonism in rat and primates. However, the mechanism of this process is not yet understood. Intrinsic firing patterns of STN neurons were examined in rat brain slices with intracellular and patch-clamp techniques. Almost half of the STN neurons that spontaneously discharged in the single-spike mode had the intrinsic property of switching to pure or mixed burst-firing mode when the membrane was hyperpolarized from
41.3 ± 1.0 mV (range,
Key words: tonic and bursting activities of STN neurons in slices; burst ionic mechanisms; low-threshold spike; Ca2+-dependent plateau potential; intracellular and patch-clamp recordings; Parkinson's disease
Copyright © 1999 Society for Neuroscience 0270-6474/99/192599-11$05.00/0
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