QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (26) Citing Articles via Google Scholar Google Scholar Articles by Nichol, K. A. Articles by Cunningham, A. M. Search for Related Content PubMed PubMed Citation Articles by Nichol, K. A. Articles by Cunningham, A. M.

 Previous Article  |  Next Article 

The Journal of Neuroscience, December 1, 1999, 19(23):10295-10304

Conservation of Expression of Neuropeptide Y5 Receptor between Human and Rat Hypothalamus and Limbic Regions Suggests an Integral Role in Central Neuroendocrine Control

Kerry Anne Nichol¹, Adrienne Morey², Michelle Heather Couzens¹, John Shine¹, Herbert Herzog¹, and Anne Marie Cunningham¹

¹ Neurobiology Program, Garvan Institute of Medical Research, and ²  Department of Anatomical Pathology, St Vincent's Hospital, Darlinghurst, New South Wales 2010, Australia

Neuropeptide Y receptors belong to the G-protein-coupled receptor superfamily and mediate a wide variety of physiological functions, including blood pressure regulation, hormone release, appetite control, seizure propensity, cognition, and emotion. The recent description of a new neuropeptide Y receptor, Y5, expressed in hypothalamic nuclei in rat brain, raised the possibility that Y5 was the receptor mediating the feeding and appetite-related functions of neuropeptide Y. This was supported by subsequent data showing a downregulation of this "feeding" receptor in the brain of the obese Zucker rat (Widdowson, 1997). We have performed a detailed analysis of Y5 expression in rat brain using in situ hybridization histochemistry with digoxygenin-labeled riboprobes and compared this to expression of Y5 in human brain regions. mRNA for the human Y5 receptor was highly expressed in human hypothalamic and thalamic nuclei. In particular, the arcuate and paraventricular nuclei of the hypothalamus, midline thalamic nuclei, and amygdala showed very high levels of expression with high levels in hippocampus. The striking conservation of expression of the rat and human Y5 receptors in relevant hypothalamic and other nuclei implies sharing of a major neuroendocrine functional role by this receptor.

Key words: NPY; Y5; in situ hybridization; appetite; hypothalamus; paraventricular; arcuate; thalamus

---

Copyright © 1999 Society for Neuroscience  0270-6474/99/192310295-10$05.00/0

This article has been cited by other articles:

				M. M. Kamiji and A. Inui Neuropeptide Y Receptor Selective Ligands in the Treatment of Obesity Endocr. Rev., October 1, 2007; 28(6): 664 - 684. [Abstract] [Full Text] [PDF]

				N. Kakui and K. Kitamura Direct Evidence that Stimulation of Neuropeptide Y Y5 Receptor Activates Hypothalamo-Pituitary-Adrenal Axis in Conscious Rats via both Corticotropin-Releasing Factor- and Arginine Vasopressin-Dependent Pathway Endocrinology, June 1, 2007; 148(6): 2854 - 2862. [Abstract] [Full Text] [PDF]

				M. Kuramochi, T. Onaka, D. Kohno, S. Kato, and T. Yada Galanin-Like Peptide Stimulates Food Intake via Activation of Neuropeptide Y Neurons in the Hypothalamic Dorsomedial Nucleus of the Rat Endocrinology, April 1, 2006; 147(4): 1744 - 1752. [Abstract] [Full Text] [PDF]

				M. M. Berglund, P. A. Hipskind, and D. R. Gehlert Recent Developments in Our Understanding of the Physiological Role of PP-Fold Peptide Receptor Subtypes Experimental Biology and Medicine, March 1, 2003; 228(3): 217 - 244. [Abstract] [Full Text] [PDF]

				A. V. Turnbull, L. Ellershaw, D. J. Masters, S. Birtles, S. Boyer, D. Carroll, P. Clarkson, S. J.G. Loxham, P. McAulay, J. L. Teague, et al. Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats Diabetes, August 1, 2002; 51(8): 2441 - 2449. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help