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The Journal of Neuroscience, December 15, 1999, 19(24):11040-11048
Evidence of a Functional Relationship between the Nucleus
Accumbens Shell and Lateral Hypothalamus Subserving the Control of
Feeding Behavior
Thomas R.
Stratford and
Ann E.
Kelley
Department of Psychiatry, University of Wisconsin-Madison Medical
School, Madison, Wisconsin 53719
Inhibition of neurons in the nucleus accumbens shell (AcbSh) with
local injections of GABA agonists or glutamate antagonists elicits an
intense, but specific, feeding response resembling that seen after
stimulation of the lateral hypothalamus (LH). To help characterize the
contribution of the LH to the expression of AcbSh-mediated feeding, we
used the immunohistochemical detection of the nuclear protein Fos to
determine whether inhibition of AcbSh cells results in an activation of
LH neurons. Injections of the GABAA agonist muscimol into
the AcbSh greatly increased the number of cells exhibiting Fos-like
immunoreactivity in the LH, as well as in the lateral septum,
paraventricular hypothalamic nucleus, ventral tegmental area,
substantia nigra pars compacta, and nucleus of the solitary tract.
Blocking activation of LH neurons with the selective NMDA receptor
blocker D( )-AP-5 is known to suppress
deprivation-induced feeding. We found that injections of
D()-AP5 into the LH also dose-dependently suppressed
AcbSh-mediated feeding.
It is likely that inhibition of GABAergic neurons in the AcbSh is
responsible for eliciting this feeding. If a behaviorally relevant
GABAergic projection terminates in the LH, we should be able to mimic
the effects seen after inhibition of the projection neurons by applying
a GABA receptor blocker to the area. However, injections of the
GABAA receptor blocker bicuculline or the GABAB receptor blocker saclofen did not significantly affect food intake. Thus, it appears that the expression of the feeding response depends on
an NMDA-preferring receptor-mediated activation of LH neurons and is
not the result of disinhibiting LH cells by disrupting transmission at
GABA synapses.
Key words:
nucleus accumbens shell; lateral hypothalamus; feeding
behavior; c-fos; GABA; NMDA; D()-AP-5
Copyright © 1999 Society for Neuroscience 0270-6474/99/192411040-09$05.00/0
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