QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (61) Citing Articles via Google Scholar Google Scholar Articles by Wilensky, A. E. Articles by LeDoux, J. E. Search for Related Content PubMed PubMed Citation Articles by Wilensky, A. E. Articles by LeDoux, J. E.

 Previous Article  |  Next Article 

The Journal of Neuroscience, 1999, 19:RC48:1-5

RAPID COMMUNICATION
Functional Inactivation of the Amygdala before But Not after Auditory Fear Conditioning Prevents Memory Formation

Ann E. Wilensky, Glenn E. Schafe, and Joseph E. LeDoux

W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003

Two competing theories predict different effects on memory consolidation when the amygdala is inactivated after fear conditioning. One theory, based on studies using inhibitory avoidance training, proposes that the amygdala modulates the strength of fear learning, and post-training amygdala manipulations interfere with memory consolidation. The other, based on studies using Pavlovian fear conditioning, hypothesizes that fear learning occurs in the amygdala, and post-training manipulations after acquisition will not affect memory consolidation. We infused the GABA_A agonist muscimol (4.4 nmol/side) or vehicle into lateral and basal amygdala (LBA) of rats either before or immediately after tone-foot shock Pavlovian fear conditioning. Pre-training infusions eliminated acquisition, whereas post-training infusions had no effect. These findings indicate that synaptic activity in LBA is necessary during learning, but that amygdala inactivation directly after training does not affect memory consolidation. Results suggest that essential aspects of plasticity underlying auditory fear conditioning take place within LBA during learning.

Key words: muscimol; learning; memory consolidation; amygdala; auditory fear conditioning; GABA

---

Copyright © 0000 Society for Neuroscience  0270-6474/0/$05.00/0

This article has been cited by other articles:

				M. Adachi, A. E. Autry, H. E. Covington III, and L. M. Monteggia MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome J. Neurosci., April 1, 2009; 29(13): 4218 - 4227. [Abstract] [Full Text] [PDF]

				M. R Delgado, J. Li, D. Schiller, and E. A Phelps The role of the striatum in aversive learning and aversive prediction errors Phil Trans R Soc B, December 12, 2008; 363(1511): 3787 - 3800. [Abstract] [Full Text] [PDF]

				J. R. Bergado-Acosta, S. Sangha, R. T. Narayanan, K. Obata, H.-C. Pape, and O. Stork Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory Learn. Mem., March 5, 2008; 15(3): 163 - 171. [Abstract] [Full Text] [PDF]

				D. W. DuBois, A. Perlegas, D. W. Floyd, J. L. Weiner, and B. A. McCool Distinct Functional Characteristics of the Lateral/Basolateral Amygdala GABAergic System in C57BL/6J and DBA/2J Mice J. Pharmacol. Exp. Ther., August 1, 2006; 318(2): 629 - 640. [Abstract] [Full Text] [PDF]

				S. Maren Building and Burying Fear Memories in the Brain Neuroscientist, February 1, 2005; 11(1): 89 - 99. [Abstract] [PDF]

				D. Pare, G. J. Quirk, and J. E. Ledoux New Vistas on Amygdala Networks in Conditioned Fear J Neurophysiol, July 1, 2004; 92(1): 1 - 9. [Abstract] [Full Text] [PDF]

				P. SAH, E. S. L. FABER, M. LOPEZ DE ARMENTIA, and J. POWER The Amygdaloid Complex: Anatomy and Physiology Physiol Rev, July 1, 2003; 83(3): 803 - 834. [Abstract] [Full Text] [PDF]

				M. E. Cain, B. S. Kapp, and C. B. Puryear The Contribution of the Amygdala to Conditioned Thalamic Arousal J. Neurosci., December 15, 2002; 22(24): 11026 - 11034. [Abstract] [Full Text] [PDF]

				E. M. Slimko, S. McKinney, D. J. Anderson, N. Davidson, and H. A. Lester Selective Electrical Silencing of Mammalian Neurons In Vitro by the Use of Invertebrate Ligand-Gated Chloride Channels J. Neurosci., September 1, 2002; 22(17): 7373 - 7379. [Abstract] [Full Text] [PDF]

				E. P. Bauer, G. E. Schafe, and J. E. LeDoux NMDA Receptors and L-Type Voltage-Gated Calcium Channels Contribute to Long-Term Potentiation and Different Components of Fear Memory Formation in the Lateral Amygdala J. Neurosci., June 15, 2002; 22(12): 5239 - 5249. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help