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The Journal of Neuroscience, February 15, 1999, 19(4):1446-1463
The Organization of Cerebellar and Basal Ganglia Outputs to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Herpes Simplex Virus Type 1
John E. Hoover1 and Peter L. Strick2, 3 1 Department of Biology, Millersville University, Millersville, Pennsylvania 17551, 2 Research Service (151S), Veterans Affairs Medical Center, Syracuse, New York 13210, and 3 Departments of Neurosurgery and Neuroscience and Physiology, State University of New York Health Science Center, Syracuse, New York 13210
We used retrograde transneuronal transport of herpes simplex virus type 1 to map the origin of cerebellar and basal ganglia "projections" to leg, arm, and face areas of the primary motor cortex (M1). Four to five days after virus injections into M1, we observed many densely labeled neurons in localized regions of the output nuclei of the cerebellum and basal ganglia. The largest numbers of these neurons were found in portions of the dentate nucleus and the internal segment of the globus pallidus (GPi). Smaller numbers of labeled neurons were found in portions of the interpositus nucleus and the substantia nigra pars reticulata. The distribution of neuronal labeling varied with the cortical injection site. For example, within the dentate, neurons labeled from leg M1 were located rostrally, those from face M1 caudally, and those from arm M1 at intermediate levels. In each instance, labeled neurons were confined to approximately the dorsal third of the nucleus. Within GPi, neurons labeled from leg M1 were located in dorsal and medial regions, those from face M1 in ventral and lateral regions, and those from arm M1 in intermediate regions. These results demonstrate that M1 is the target of somatotopically organized outputs from both the cerebellum and basal ganglia. Surprisingly, the projections to M1 originate from only 30% of the volume of the dentate and <15% of GPi. Thus, the majority of the outputs from the cerebellum and basal ganglia are directed to cortical areas other than M1.
Key words: primary motor cortex; cerebellum; basal ganglia; thalamus; transneuronal transport; herpes simplex virus; primate; motor control
Copyright © 1999 Society for Neuroscience 0270-6474/99/1941446-18$05.00/0
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