 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, March 1, 1999, 19(5):1657-1662
Ischemic Tolerance in Murine Cortical Cell Culture: Critical Role for NMDA Receptors
Margaret C. Grabb and Dennis W. Choi Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110
Murine cortical cultures containing both neurons and glia (days in vitro 13-15) were exposed to periods of oxygen-glucose deprivation (5-30 min) too brief to induce neuronal death. Cultures "preconditioned" by sublethal oxygen-glucose deprivation exhibited 30-50% less neuronal death than controls when exposed to a 45-55 min period of oxygen-glucose deprivation 24 hr later. This preconditioning-induced neuroprotection was specific in that neuronal death induced by exposure to excitotoxins or to staurosporine was not attenuated. Neuroprotection was lost if the time between the preconditioning and severe insult were decreased to 7 hr or increased to 72 hr and was blocked if the NMDA antagonist 100 µM 3-((D)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid was applied during the preconditioning insult. This was true even if the duration of preconditioning was increased as far as possible (while still remaining sublethal). A similar preconditioning effect was also produced by sublethal exposure to high K+, glutamate, or NMDA but not to kainate or trans-1-aminocyclopentane-1,3-dicarboxylic acid.
Key words: glutamate; cerebral preconditioning; NMDA; kainate; metabotropic; ischemia
Copyright © 1999 Society for Neuroscience 0270-6474/99/1951657-06$05.00/0
This article has been cited by other articles:
J. S. Tauskela, H. Fang, M. Hewitt, E. Brunette, T. Ahuja, J.-P. Thivierge, T. Comas, and G. A. R. Mealing
Elevated Synaptic Activity Preconditions Neurons against an in Vitro Model of Ischemia
J. Biol. Chem., December 12, 2008; 283(50): 34667 - 34676.
[Abstract] [Full Text] [PDF]
M. Chen, T.-J. Lu, X.-J. Chen, Y. Zhou, Q. Chen, X.-Y. Feng, L. Xu, W.-H. Duan, and Z.-Q. Xiong
Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance
Stroke, November 1, 2008; 39(11): 3042 - 3048.
[Abstract] [Full Text] [PDF]
B. P. Head, H. H. Patel, Y. M. Tsutsumi, Y. Hu, T. Mejia, R. C. Mora, P. A. Insel, D. M. Roth, J. C. Drummond, and P. M. Patel
Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death
FASEB J, March 1, 2008; 22(3): 828 - 840.
[Abstract] [Full Text] [PDF]
S. Papadia and G. E. Hardingham
The Dichotomy of NMDA Receptor Signaling
Neuroscientist, December 1, 2007; 13(6): 572 - 579.
[Abstract] [PDF]
K. Chu, S.-T. Lee, D.-I. Sinn, S.-Y. Ko, E.-H. Kim, J.-M. Kim, S.-J. Kim, D.-K. Park, K.-H. Jung, E.-C. Song, et al.
Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 (EAAT2) Upregulation
Stroke, January 1, 2007; 38(1): 177 - 182.
[Abstract] [Full Text] [PDF]
J. C. de Rivero Vaccari, G. P. Casey, S. Aleem, W.-M. Park, and R. A. Corriveau
NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death
PNAS, November 7, 2006; 103(45): 16971 - 16976.
[Abstract] [Full Text] [PDF]
F. X. Soriano, S. Papadia, F. Hofmann, N. R. Hardingham, H. Bading, and G. E. Hardingham
Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability.
J. Neurosci., April 26, 2006; 26(17): 4509 - 4518.
[Abstract] [Full Text] [PDF]
T. Kaneko, K. Yokoyama, and K. Makita
Late preconditioning with isoflurane in cultured rat cortical neurones
Br. J. Anaesth., November 1, 2005; 95(5): 662 - 668.
[Abstract] [Full Text] [PDF]
B. Miao, X.-H. Yin, D.-S. Pei, Q.-G. Zhang, and G.-Y. Zhang
Neuroprotective Effects of Preconditioning Ischemia on Ischemic Brain Injury through Down-regulating Activation of JNK1/2 via N-Methyl-D-aspartate Receptor-mediated Akt1 Activation
J. Biol. Chem., June 10, 2005; 280(23): 21693 - 21699.
[Abstract] [Full Text] [PDF]
Y.-F. Lin, K. Raab-Graham, Y. N. Jan, and L. Y. Jan
NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection
PNAS, May 18, 2004; 101(20): 7799 - 7804.
[Abstract] [Full Text] [PDF]
H. Tanaka, H. Yokota, T. Jover, I. Cappuccio, A. Calderone, M. Simionescu, M. V. L. Bennett, and R. S. Zukin
Ischemic Preconditioning: Neuronal Survival in the Face of Caspase-3 Activation
J. Neurosci., March 17, 2004; 24(11): 2750 - 2759.
[Abstract] [Full Text] [PDF]
C. Romera, O. Hurtado, S. H. Botella, I. Lizasoain, A. Cardenas, P. Fernandez-Tome, J. C. Leza, P. Lorenzo, and M. A. Moro
In Vitro Ischemic Tolerance Involves Upregulation of Glutamate Transport Partly Mediated by the TACE/ADAM17-Tumor Necrosis Factor-{alpha} Pathway
J. Neurosci., February 11, 2004; 24(6): 1350 - 1357.
[Abstract] [Full Text] [PDF]
J. S. Tauskela, E. Brunette, R. Monette, T. Comas, and P. Morley
Preconditioning of cortical neurons by oxygen-glucose deprivation: tolerance induction through abbreviated neurotoxic signaling
Am J Physiol Cell Physiol, October 1, 2003; 285(4): C899 - C911.
[Abstract] [Full Text] [PDF]
K. Prass, A. Scharff, K. Ruscher, D. Lowl, C. Muselmann, I. Victorov, K. Kapinya, U. Dirnagl, and A. Meisel
Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by Erythropoietin
Stroke, August 1, 2003; 34(8): 1981 - 1986.
[Abstract] [Full Text] [PDF]
W. Deng, P. A. Rosenberg, J. J. Volpe, and F. E. Jensen
Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors
PNAS, May 27, 2003; 100(11): 6801 - 6806.
[Abstract] [Full Text] [PDF]
A. P. Raval, K. R. Dave, D. Mochly-Rosen, T. J. Sick, and M. A. Perez-Pinzon
epsilon PKC Is Required for the Induction of Tolerance by Ischemic and NMDA-Mediated Preconditioning in the Organotypic Hippocampal Slice
J. Neurosci., January 15, 2003; 23(2): 384 - 391.
[Abstract] [Full Text] [PDF]
K. Ruscher, D. Freyer, M. Karsch, N. Isaev, D. Megow, B. Sawitzki, J. Priller, U. Dirnagl, and A. Meisel
Erythropoietin Is a Paracrine Mediator of Ischemic Tolerance in the Brain: Evidence from an In Vitro Model
J. Neurosci., December 1, 2002; 22(23): 10291 - 10301.
[Abstract] [Full Text] [PDF]
Y. Konishi, K. Lindholm, L.-B. Yang, R. Li, and Y. Shen
Isolation of Living Neurons from Human Elderly Brains Using the Immunomagnetic Sorting DNA-Linker System
Am. J. Pathol., November 1, 2002; 161(5): 1567 - 1576.
[Abstract] [Full Text] [PDF]
A. Wick, W. Wick, J. Waltenberger, M. Weller, J. Dichgans, and J. B. Schulz
Neuroprotection by Hypoxic Preconditioning Requires Sequential Activation of Vascular Endothelial Growth Factor Receptor and Akt
J. Neurosci., August 1, 2002; 22(15): 6401 - 6407.
[Abstract] [Full Text] [PDF]
N. J. Alkayed, T. Goyagi, H.-D. Joh, J. Klaus, D. R. Harder, R. J. Traystman, and P. D. Hurn
Neuroprotection and P450 2C11 Upregulation After Experimental Transient Ischemic Attack
Stroke, June 1, 2002; 33(6): 1677 - 1684.
[Abstract] [Full Text] [PDF]
H. Tanaka, A. Calderone, T. Jover, S. Y. Grooms, H. Yokota, R. S. Zukin, and M. V. L. Bennett
Ischemic preconditioning acts upstream of GluR2 down-regulation to afford neuroprotection in the hippocampal CA1
PNAS, February 6, 2002; (2002) 261713299.
[Abstract] [Full Text] [PDF]
G.-W. Lu and H.-Y. Liu
Downregulation of nitric oxide in the brain of mice during their hypoxic preconditioning
J Appl Physiol, September 1, 2001; 91(3): 1193 - 1198.
[Abstract] [Full Text] [PDF]
K. Nandagopal, T. M. Dawson, and V. L. Dawson
Critical Role for Nitric Oxide Signaling in Cardiac and Neuronal Ischemic Preconditioning and Tolerance
J. Pharmacol. Exp. Ther., April 12, 2001; 297(2): 474 - 478.
[Abstract] [Full Text]
R. Tremblay, B. Chakravarthy, K. Hewitt, J. Tauskela, P. Morley, T. Atkinson, and J. P. Durkin
Transient NMDA Receptor Inactivation Provides Long-Term Protection to Cultured Cortical Neurons from a Variety of Death Signals
J. Neurosci., October 1, 2000; 20(19): 7183 - 7192.
[Abstract] [Full Text] [PDF]
M. Gonzalez-Zulueta, A. B. Feldman, L. J. Klesse, R. G. Kalb, J. F. Dillman, L. F. Parada, T. M. Dawson, and V. L. Dawson
Requirement for nitric oxide activation of p21ras/extracellular regulated kinase in neuronal ischemic preconditioning
PNAS, January 4, 2000; 97(1): 436 - 441.
[Abstract] [Full Text] [PDF]
H. Tanaka, A. Calderone, T. Jover, S. Y. Grooms, H. Yokota, R. S. Zukin, and M. V. L. Bennett
Ischemic preconditioning acts upstream of GluR2 down-regulation to afford neuroprotection in the hippocampal CA1
PNAS, February 19, 2002; 99(4): 2362 - 2367.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|