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The Journal of Neuroscience, March 15, 1999, 19(6):2171-2180
Adult Subventricular Zone Neuronal Precursors Continue to Proliferate and Migrate in the Absence of the Olfactory Bulb
Barry Kirschenbaum1, Fiona Doetsch1, Carlos Lois2, and Arturo Alvarez-Buylla1 1 The Rockefeller University, New York, New York 10021, and 2 California Institute of Technology, Pasadena, California 91125
Neurons continue to be born in the subventricular zone (SVZ) of the lateral ventricles of adult mice. These cells migrate as a network of chains through the SVZ and the rostral migratory stream (RMS) into the olfactory bulb (OB), where they differentiate into mature neurons. The OB is the only known target for these neuronal precursors. Here, we show that, after elimination of the OB, the SVZ and RMS persist and become dramatically larger. The proportion of dividing [bromodeoxyuridine (BrdU)-labeled] or dying (pyknotic or terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end-labeled) cells in the RMS was not significantly affected at 3 d or 3 weeks after bulbectomy (OBX). However, by 3 months after OBX, the percentage of BrdU-labeled cells in the RMS decreased by half and that of dying cells doubled. Surprisingly, the rostral migration of precursors continued along the RMS after OBX. This was demonstrated by focal microinjections of BrdU and grafts of SVZ cells carrying LacZ under the control of a neuron-specific promoter gene. Results indicate that the OB is not essential for proliferation and the directional migration of SVZ precursors.
Key words: bulbectomy; adult; subventricular zone; neuronal precursors; subependymal layer; cell death
Copyright © 1999 Society for Neuroscience 0270-6474/99/1962171-10$05.00/0
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