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The Journal of Neuroscience, April 1, 1999, 19(7):2647-2657

Cortical Visuomotor Integration during Eye Pursuit and Eye-Finger Pursuit

Nobuyuki Nishitani¹, Kimmo Uutela¹, Hiroshi Shibasaki², and Riitta Hari^{1, 3}

¹ Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland, ² Department of Brain Pathophysiology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan, and ³ Department of Clinical Neurosciences, Helsinki University Central Hospital, FIN-00290, Helsinki, Finland

To elucidate cortical mechanisms of visuomotor integration, we recorded whole-scalp neuromagnetic signals from six normal volunteers while they were viewing a black dot moving linearly at the speed of 4°/sec within a virtual rectangle. The dot changed its direction randomly once every 0.3-2 sec. The subject either (1) fixated a cross in the center of the screen (eye fixation task), (2) followed the moving dot with the eyes (eye pursuit task), or (3) followed the dot with both the eyes and the right index finger (eye-finger pursuit task). Prominent magnetic signals, triggered by the changes of the direction of the dot, were seen in all conditions, but they were clearly enhanced by the tasks and were strongest during the eye-finger pursuit task and over the anterior inferior parietal lobule (aIPL). Source modeling indicated activation of aIPL [Brodmann's area (BA) 40], the posterosuperior parietal lobule (SPL; BA 7), the dorsolateral frontal cortex (DLF; BA 6), and the occipital cortex (BA 18/19). The activation first peaked in the occipital areas, then in the aIPL and DLF, and some 50 msec later in the SPL. Our results suggest that all these areas are involved in visuomotor transformation, with aIPL playing a crucial role in this process.

Key words: visuomotor integration; eye-finger pursuit; smooth pursuit; fixation; MEG; anterior inferior parietal lobule; human

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Copyright © 1999 Society for Neuroscience  0270-6474/99/1972647-11$05.00/0

This article has been cited by other articles:

				A. Ledberg, S. L. Bressler, M. Ding, R. Coppola, and R. Nakamura Large-Scale Visuomotor Integration in the Cerebral Cortex Cereb Cortex, January 1, 2007; 17(1): 44 - 62. [Abstract] [Full Text] [PDF]

				S. Levanen, K. Uutela, S. Salenius, and R. Hari Cortical Representation of Sign Language: Comparison of Deaf Signers and Hearing Non-signers Cereb Cortex, June 1, 2001; 11(6): 506 - 512. [Abstract] [Full Text] [PDF]

				N. Nishitani and R. Hari Temporal dynamics of cortical representation for action PNAS, January 18, 2000; 97(2): 913 - 918. [Abstract] [Full Text] [PDF]

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