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The Journal of Neuroscience, January 1, 2000, 20(1):114-122
Electrophysiological Characterization of Voltage-Gated K+ Currents in Cerebellar Basket and Purkinje Cells: Kv1 and Kv3 Channel Subfamilies Are Present in Basket Cell Nerve Terminals
Andrew P. Southan and Brian Robertson Electrophysiology Group, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, United Kingdom
To understand the processes underlying fast synaptic transmission in the mammalian CNS, we must have detailed knowledge of the identity, location, and physiology of the ion channels in the neuronal membrane. From labeling studies we can get clues regarding the distribution of ion channels, but electrophysiological methods are required to determine the importance of each ion channel in CNS transmission. Dendrotoxin-sensitive potassium channel subunits are highly concentrated in cerebellar basket cell nerve terminals, and we have previously shown that they are responsible for a significant fraction of the voltage-gated potassium current in this region. Here, we further investigate the characteristics and pharmacology of the voltage-dependent potassium currents in these inhibitory nerve terminals and compare these observations with those obtained from somatic recordings in basket and Purkinje cell soma regions. We find that
-DTX blocks basket cell nerve terminal currents and not somatic currents, and the IC50 for
Key words: potassium channels; cerebellum; synapse; basket cell; electrophysiology; mouse
Copyright © 2000 Society for Neuroscience 0270-6474/0/201114-09$05.00/0
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