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The Journal of Neuroscience, January 1, 2000, 20(1):375-386
Dependence of GABAergic Synaptic Areas on the Interneuron Type and Target Size
Yoshiyuki Kubota1 and Yasuo Kawaguchi1, 2 1 Laboratory for Neural Circuits, Bio-Mimetic Control Research Center, The Institute of Physical and Chemical Research (RIKEN), Moriyama, Nagoya 463-0003, Japan, and 2 Laboratory of Cerebral Circuitry, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan
In the neostriatum, several types of interneuron with distinct firing patterns and expression of neuroactive substances are known to exist. We found two types of neostriatal interneurons, parvalbumin-containing fast-spiking (FS) cells and somatostatin-containing low-threshold spike (LTS) cells to both be immunoreactive for GABA at their axon terminals in immersion-fixed brain slices from rat. To reveal the differences in synaptic connections between these two types of GABAergic interneurons, the postsynaptic target and their synaptic structure were compared by three-dimensional reconstructions from electron microscopic images of intracellularly stained axon terminals. FS cells made a greater proportion of synaptic contacts onto somata than LTS cells. Although terminal boutons of FS and LTS cells were similar in volume, their synaptic junctional areas differed in size distribution and relation to the dimensions of postsynaptic dendritic shafts or spines. Whereas the synaptic junctional areas of FS cells (0.024-0.435 µm2; n = 28) sharply and linearly increased with the circumference of the postsynaptic dendrites or spines (0.939-5.146 µm), the slope for the junctional area of LTS cells (0.02-0.103 µm2; n = 29) against circumference (0.844-4.252 µm) was less steep, and a much weaker correlation was seen. In addition to the differences in firing patterns, expressed molecules, axonal arborizations, and postsynaptic targets, this variation in dependency of the synaptic area on the target size suggests functional differentiation of GABAergic interneurons.
Key words: neostriatum; interneuron; GABA; parvalbumin; somatostatin; fast spiking cell; low threshold spike; postsynaptic structure; synaptic junctional area
Copyright © 2000 Society for Neuroscience 0270-6474/0/201375-12$05.00/0
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