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The Journal of Neuroscience, June 15, 2000, 20(12):4563-4572
The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response
Element-Binding Protein to Control Long-Term Potentiation-Dependent
Gene Expression in the Dentate Gyrus In Vivo
Sabrina
Davis1,
Peter
Vanhoutte2,
Christiane
Pagès2,
Jocelyne
Caboche2, and
Serge
Laroche1
1 Laboratoire de Neurobiologie de l'Apprentissage, de
la Mémoire, et de la Communication, Centre National de la
Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR)
8620, Université Paris Sud, 91405 Orsay, France, and
2 Laboratoire de Neurochimie-Anatomie, Institut des
Neurosciences, CNRS UMR 7624, Universtité Pierre et Marie Curie,
75005 Paris, France
The mitogen-activated protein kinase/extracellular signal-regulated
kinase (MAPK/ERK) signaling cascade contributes to synaptic plasticity and to long-term memory formation, yet whether MAPK/ERK controls activity-dependent gene expression critical for long-lasting changes at the synapse and what the events underlying transduction of
the signal are remain uncertain. Here we show that induction of
long-term potentiation (LTP) in the dentate gyrus in
vivo leads to rapid phosphorylation and nuclear translocation
of MAPK/ERK. Following a similar time course, the two downstream
transcriptional targets of MAPK/ERK, cAMP response element-binding
protein (CREB) and the ternary complex factor Elk-1, a key
transcriptional-regulator of serum response element (SRE)-driven gene
expression, were hyperphosphorylated and the immediate early gene
zif268 was upregulated. The mRNA encoding MAP kinase phosphatase MKP-1
was upregulated at the time point when MAPK/ERK phosphorylation had
returned to basal levels, suggesting a negative feedback loop to
regulate deactivation of MAPK/ERK. We also show that inhibition of the
MAPK/ERK cascade by the MAPK kinase MEK inhibitor SL327
prevented CREB and Elk-1 phosphorylation, and LTP-dependent gene
induction, resulting in rapidly decaying LTP. In conclusion, we suggest
that Elk-1 forms an important link in the MAP kinase pathway to
transduce signals from the cell surface to the nucleus to activate the
genetic machinery necessary for the maintenance of synaptic plasticity
in the dentate gyrus. Thus, MAPK/ERK activation is required for
LTP-dependent transcriptional regulation and we suggest this is
regulated by two parallel signaling pathways, the MAPK/ERK-Elk-1
pathway targeting SRE and the MAPK/ERK-CREB pathway targeting CRE.
Key words:
hippocampus; LTP; MAPK/ERK; Elk-1 phosphorylation; zif268; transcriptional regulation
Copyright © 2000 Society for Neuroscience 0270-6474/00/20124563-10$05.00/0
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|
|
|
|
|
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14(6):
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|
|
|
|
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27(22):
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|
|
|
|
|
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|
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281(40):
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|
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|
|
|
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|
|
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|
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|
|
|
|
|
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|
|
|
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|
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26(22):
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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103(13):
5155 - 5160.
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|
|
|
|
|
|
|
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26(3):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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J. Physiol.,
January 1, 2006;
570(1):
97 - 111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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December 1, 2005;
135(12):
2987S - 2992S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Navakkode, S. Sajikumar, and J. U. Frey
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25(46):
10664 - 10670.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. A. Mohamed, W. Yao, D. Fioravante, P. D. Smolen, and J. H. Byrne
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J. Biol. Chem.,
July 22, 2005;
280(29):
27035 - 27043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Refojo, C. Echenique, M. B. Muller, J. M. H. M. Reul, J. M. Deussing, W. Wurst, I. Sillaber, M. Paez-Pereda, F. Holsboer, and E. Arzt
Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas
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April 26, 2005;
102(17):
6183 - 6188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Mao, L. Yang, Q. Tang, S. Samdani, G. Zhang, and J. Q. Wang
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J. Neurosci.,
March 9, 2005;
25(10):
2741 - 2752.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-C. Corvol, E. Valjent, M. Toutant, H. Enslen, T. Irinopoulou, S. Lev, D. Herve, and J.-A. Girault
Depolarization Activates ERK and Proline-rich Tyrosine Kinase 2 (PYK2) Independently in Different Cellular Compartments in Hippocampal Slices
J. Biol. Chem.,
January 7, 2005;
280(1):
660 - 668.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Palozza, S. Serini, N. Maggiano, G. Tringali, P. Navarra, F. O. Ranelletti, and G. Calviello
{beta}-Carotene Downregulates the Steady-State and Heregulin-{alpha}-Induced COX-2 Pathways in Colon Cancer Cells
J. Nutr.,
January 1, 2005;
135(1):
129 - 136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Levenson, K. J. O'Riordan, K. D. Brown, M. A. Trinh, D. L. Molfese, and J. D. Sweatt
Regulation of Histone Acetylation during Memory Formation in the Hippocampus
J. Biol. Chem.,
September 24, 2004;
279(39):
40545 - 40559.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Liu, Y. J. Suzuki, R. M. Day, and B. L. Fanburg
Rho Kinase-Induced Nuclear Translocation of ERK1/ERK2 in Smooth Muscle Cell Mitogenesis Caused by Serotonin
Circ. Res.,
September 17, 2004;
95(6):
579 - 586.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-Y. Cheng and D. F. Clayton
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J. Neurosci.,
August 25, 2004;
24(34):
7503 - 7513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Naska, M. C. Cenni, E. Menna, and L. Maffei
ERK signaling is required for eye-specific retino-geniculate segregation
Development,
August 1, 2004;
131(15):
3559 - 3570.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Tong, R. Balazs, P. L. Thornton, and C. W. Cotman
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J. Neurosci.,
July 28, 2004;
24(30):
6799 - 6809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Sharma and T. J. Carew
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Learn. Mem.,
July 1, 2004;
11(4):
373 - 378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Mizoguchi, K. Yamada, M. Mizuno, T. Mizuno, A. Nitta, Y. Noda, and T. Nabeshima
Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like Gene-1 Signaling Pathway via the Activation of Dopamine Receptors
Mol. Pharmacol.,
May 1, 2004;
65(5):
1293 - 1301.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. M. Khan and A. G. Watts
Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels of the Phosphorylated Forms of p44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) in Rat Hypothalamic Parvicellular Paraventricular Neurons
Endocrinology,
January 1, 2004;
145(1):
351 - 359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. C. Abraham and J. M. Williams
Properties and Mechanisms of LTP Maintenance
Neuroscientist,
December 1, 2003;
9(6):
463 - 474.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.A. Lemon, D.R. Boreham, and C.D. Rollo
A Dietary Supplement Abolishes Age-Related Cognitive Decline in Transgenic Mice Expressing Elevated Free Radical Processes
Experimental Biology and Medicine,
July 1, 2003;
228(7):
800 - 810.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Dickey, J. F. Loring, J. Montgomery, M. N. Gordon, P. S. Eastman, and D. Morgan
Selectively Reduced Expression of Synaptic Plasticity-Related Genes in Amyloid Precursor Protein + Presenilin-1 Transgenic Mice
J. Neurosci.,
June 15, 2003;
23(12):
5219 - 5226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kelly, S. Laroche, and S. Davis
Activation of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase in Hippocampal Circuitry Is Required for Consolidation and Reconsolidation of Recognition Memory
J. Neurosci.,
June 15, 2003;
23(12):
5354 - 5360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-L. Chien, K.-C. Liang, C.-M. Teng, S.-C. Kuo, F.-Y. Lee, and W.-M. Fu
Enhancement of Long-Term Potentiation by a Potent Nitric Oxide-Guanylyl Cyclase Activator, 3-(5-Hydroxymethyl-2-furyl)-1-benzyl-indazole
Mol. Pharmacol.,
June 1, 2003;
63(6):
1322 - 1328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. C. Yang, Y. L. Ma, S. K. Chen, C. W. Wang, and E. H. Y. Lee
Focal Adhesion Kinase Is Required, But Not Sufficient, for the Induction of Long-Term Potentiation in Dentate Gyrus Neurons In Vivo
J. Neurosci.,
May 15, 2003;
23(10):
4072 - 4080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Opazo, A. M. Watabe, S. G. N. Grant, and T. J. O'Dell
Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms
J. Neurosci.,
May 1, 2003;
23(9):
3679 - 3688.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Sharma, C. M. Sherff, J. Shobe, M. W. Bagnall, M. A. Sutton, and T. J. Carew
Differential Role of Mitogen-Activated Protein Kinase in Three Distinct Phases of Memory for Sensitization in Aplysia
J. Neurosci.,
May 1, 2003;
23(9):
3899 - 3907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. N. Coogan and H. D. Piggins
Circadian and Photic Regulation of Phosphorylation of ERK1/2 and Elk-1 in the Suprachiasmatic Nuclei of the Syrian Hamster
J. Neurosci.,
April 1, 2003;
23(7):
3085 - 3093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Selcher, E. J. Weeber, J. Christian, T. Nekrasova, G. E. Landreth, and J. D. Sweatt
A Role for ERK MAP Kinase in Physiologic Temporal Integration in Hippocampal Area CA1
Learn. Mem.,
January 1, 2003;
10(1):
26 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hetman, S.-L. Hsuan, A. Habas, M. J. Higgins, and Z. Xia
ERK1/2 Antagonizes Glycogen Synthase Kinase-3beta -induced Apoptosis in Cortical Neurons
J. Biol. Chem.,
December 13, 2002;
277(51):
49577 - 49584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Moon and J. J. Pestka
Vomitoxin-Induced Cyclooxygenase-2 Gene Expression in Macrophages Mediated by Activation of ERK and p38 but Not JNK Mitogen-Activated Protein Kinases
Toxicol. Sci.,
October 1, 2002;
69(2):
373 - 382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Messaoudi, S.-W. Ying, T. Kanhema, S. D. Croll, and C. R. Bramham
Brain-Derived Neurotrophic Factor Triggers Transcription-Dependent, Late Phase Long-Term Potentiation In Vivo
J. Neurosci.,
September 1, 2002;
22(17):
7453 - 7461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Rosenblum, M. Futter, K. Voss, M. Erent, P. A. Skehel, P. French, L. Obosi, M. W. Jones, and T. V. P. Bliss
The Role of Extracellular Regulated Kinases I/II in Late-Phase Long-Term Potentiation
J. Neurosci.,
July 1, 2002;
22(13):
5432 - 5441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Dudek and R. D. Fields
Somatic action potentials are sufficient for late-phase LTP-related cell signaling
PNAS,
March 19, 2002;
99(6):
3962 - 3967.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Thiels, B. I. Kanterewicz, E. D. Norman, J. M. Trzaskos, and E. Klann
Long-Term Depression in the Adult Hippocampus In Vivo Involves Activation of Extracellular Signal-Regulated Kinase and Phosphorylation of Elk-1
J. Neurosci.,
March 15, 2002;
22(6):
2054 - 2062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-W. Ying, M. Futter, K. Rosenblum, M. J. Webber, S. P. Hunt, T. V. P. Bliss, and C. R. Bramham
Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of Arc Synthesis
J. Neurosci.,
March 1, 2002;
22(5):
1532 - 1540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Giovannini, R. D. Blitzer, T. Wong, K. Asoma, P. Tsokas, J. H. Morrison, R. Iyengar, and E. M. Landau
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J. Neurosci.,
September 15, 2001;
21(18):
7053 - 7062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
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S. M. Rodrigues, G. E. Schafe, and J. E. LeDoux
Intra-Amygdala Blockade of the NR2B Subunit of the NMDA Receptor Disrupts the Acquisition But Not the Expression of Fear Conditioning
J. Neurosci.,
September 1, 2001;
21(17):
6889 - 6896.
[Abstract]
[Full Text]
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Y. Dai, C. Yu, V. Singh, L. Tang, Z. Wang, R. McInistry, P. Dent, and S. Grant
Pharmacological Inhibitors of the Mitogen-activated Protein Kinase (MAPK) Kinase/MAPK Cascade Interact Synergistically with UCN-01 to Induce Mitochondrial Dysfunction and Apoptosis in Human Leukemia Cells
Cancer Res.,
July 1, 2001;
61(13):
5106 - 5115.
[Abstract]
[Full Text]
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K. T. Dineley, M. Westerman, D. Bui, K. Bell, K. H. Ashe, and J. D. Sweatt
{beta}-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal {alpha}7 Nicotinic Acetylcholine Receptors: In Vitro and In Vivo Mechanisms Related to Alzheimer's Disease
J. Neurosci.,
June 15, 2001;
21(12):
4125 - 4133.
[Abstract]
[Full Text]
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M. Sato, K. Suzuki, and S. Nakanishi
NMDA Receptor Stimulation and Brain-Derived Neurotrophic Factor Upregulate Homer 1a mRNA via the Mitogen-Activated Protein Kinase Cascade in Cultured Cerebellar Granule Cells
J. Neurosci.,
June 1, 2001;
21(11):
3797 - 3805.
[Abstract]
[Full Text]
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P. Dent and S. Grant
Pharmacologic Interruption of the Mitogen-activated Extracellular-regulated Kinase/Mitogen-activated Protein Kinase Signal Transduction Pathway: Potential Role in PromotingCytotoxic Drug Action
Clin. Cancer Res.,
April 1, 2001;
7(4):
775 - 783.
[Full Text]
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S. C. Pandey, A. Roy, and N. Mittal
Effects of Chronic Ethanol Intake and Its Withdrawal on the Expression and Phosphorylation of the CREB Gene Transcription Factor in Rat Cortex
J. Pharmacol. Exp. Ther.,
March 1, 2001;
296(3):
857 - 868.
[Abstract]
[Full Text]
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G.-Y. Wu, K. Deisseroth, and R. W. Tsien
Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway
PNAS,
February 15, 2001;
(2001)
51634198.
[Abstract]
[Full Text]
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J. C. Selcher, T. Nekrasova, R. Paylor, G. E. Landreth, and J. D. Sweatt
Mice Lacking the ERK1 Isoform of MAP Kinase Are Unimpaired in Emotional Learning
Learn. Mem.,
January 1, 2001;
8(1):
11 - 19.
[Abstract]
[Full Text]
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E. Valjent, J.-C. Corvol, C. Pages, M.-J. Besson, R. Maldonado, and J. Caboche
Involvement of the Extracellular Signal-Regulated Kinase Cascade for Cocaine-Rewarding Properties
J. Neurosci.,
December 1, 2000;
20(23):
8701 - 8709.
[Abstract]
[Full Text]
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G.-Y. Wu, K. Deisseroth, and R. W. Tsien
Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway
PNAS,
February 27, 2001;
98(5):
2808 - 2813.
[Abstract]
[Full Text]
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S. M. Dudek and R. D. Fields
Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Activation in Somatodendritic Compartments: Roles of Action Potentials, Frequency, and Mode of Calcium Entry
J. Neurosci.,
January 15, 2001;
21(2):
RC122 - RC122.
[Abstract]
[Full Text]
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K.-T. Lu, D. L. Walker, and M. Davis
Mitogen-Activated Protein Kinase Cascade in the Basolateral Nucleus of Amygdala Is Involved in Extinction of Fear-Potentiated Startle
J. Neurosci.,
August 15, 2001;
21(16):
RC162 - RC162.
[Abstract]
[Full Text]
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