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The Journal of Neuroscience, July 15, 2000, 20(14):5420-5436
Different Subthreshold Mechanisms Underlie Song Selectivity in
Identified HVc Neurons of the Zebra Finch
Richard
Mooney
Department of Neurobiology, Duke University Medical Center, Durham,
North Carolina 27710
Songbirds learn and maintain their songs via auditory experience.
Neurons in many telencephalic nuclei important to song production and
development are song selective, firing more to forward auditory playback of the bird's own song (BOS) than to reverse BOS or
conspecific songs. Elucidating circuits that generate these responses
can localize where auditory experience influences vocalization,
bridging cellular and systems analyses of song learning. Song-selective responses in many song nuclei, including the vocal premotor nucleus robustus archistriatalis (RA) and the basal ganglia homolog area X, are
thought to originate in nucleus HVc (used as a proper name), which contains interneurons and relay cells that innervate either RA or
area X. Previous studies indicated that only X-projecting neurons have
auditory responses, leaving open the source of RA's auditory input and
the degree to which song selectivity may be refined in HVc. Here,
in vivo intracellular recordings from morphologically and electrophysiologically identified HVc neurons revealed that both
relay cell types fire song-selectively. However, their firing arises
via markedly different subthreshold processes, and only X-projecting
neurons appear to be sites for auditory refinement. RA-projecting
neurons exhibited purely depolarizing subthreshold responses that were
highly song selective and that were excitatory. In contrast,
subthreshold responses of X-projecting neurons included less-selective
depolarizing and highly selective hyperpolarizing components. Within
individual birds, these BOS-evoked hyperpolarizations closely matched
interneuronal firing, suggesting that HVc interneurons make restricted
inputs onto X-projecting neurons. Because of the two relay cell types'
subthreshold differences, factors affecting their resting membrane
potentials could enable them to transmit distinct song representations
to their targets.
Key words:
HVc; in vivo intracellular; vocal learning; songbirds; song; auditory selectivity; communication; zebra finch
Copyright © 2000 Society for Neuroscience 0270-6474/00/20145420-17$05.00/0
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