 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, August 1, 2000, 20(15):5764-5774
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Tarik F. Haydar, Feng Wang, Michael L. Schwartz, and Pasko Rakic Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510
Recent studies have implicated the classical neurotransmitters GABA and glutamate in the regulation of neural progenitor proliferation. We now show that GABA and glutamate have opposite effects on the two neural progenitor populations in the ventricular zones (VZs) and subventricular zones (SVZs) of the embryonic cerebrum. Application of either molecule to organotypic slice cultures dramatically increases proliferation in the VZ by shortening the cell cycle, whereas proliferation in the SVZ is decreased. These disparate effects, measured both by bromodeoxyuridine uptake and the expansion of retrovirally labeled progenitor clones, are mimicked by the application of specific GABA and glutamate agonists and are blocked by antagonists. Thus, the relative contributions of the VZ and SVZ to neocortical growth may be regulated by differential responsiveness to GABA and glutamate.
Key words: neurogenesis; neurotransmitter; progenitor; cell cycle; cerebral cortex; corticogenesis
Copyright © 2000 Society for Neuroscience 0270-6474/00/20155764-11$05.00/0
This article has been cited by other articles:
T. Kowalczyk, A. Pontious, C. Englund, R. A. M. Daza, F. Bedogni, R. Hodge, A. Attardo, C. Bell, W. B. Huttner, and R. F. Hevner
Intermediate Neuronal Progenitors (Basal Progenitors) Produce Pyramidal-Projection Neurons for All Layers of Cerebral Cortex
Cereb Cortex, October 1, 2009; 19(10): 2439 - 2450.
[Abstract] [Full Text] [PDF]
D. M. Feliciano and A. M. Edelman
Repression of Ca2+/Calmodulin-dependent Protein Kinase IV Signaling Accelerates Retinoic Acid-induced Differentiation of Human Neuroblastoma Cells
J. Biol. Chem., September 25, 2009; 284(39): 26466 - 26481.
[Abstract] [Full Text] [PDF]
D. D. Wang and A. R. Kriegstein
Defining the role of GABA in cortical development
J. Physiol., May 1, 2009; 587(9): 1873 - 1879.
[Abstract] [Full Text] [PDF]
X. Liu, K. Hashimoto-Torii, M. Torii, T. F. Haydar, and P. Rakic
The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone
PNAS, August 19, 2008; 105(33): 11802 - 11807.
[Abstract] [Full Text] [PDF]
Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Physiol Rev, October 1, 2007; 87(4): 1215 - 1284.
[Abstract] [Full Text] [PDF]
L. Cancedda, H. Fiumelli, K. Chen, and M.-m. Poo
Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons In Vivo
J. Neurosci., May 9, 2007; 27(19): 5224 - 5235.
[Abstract] [Full Text] [PDF]
J.-Y. Joo, B.-W. Kim, J.-S. Lee, J.-Y. Park, S. Kim, Y.-J. Yun, S.-H. Lee, S.-H. Lee, H. Rhim, and H. Son
Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells
J. Cell Sci., April 15, 2007; 120(8): 1358 - 1370.
[Abstract] [Full Text] [PDF]
J. Berger, S. Berger, T. C. Tuoc, M. D'Amelio, F. Cecconi, J. A. Gorski, K. R. Jones, P. Gruss, and A. Stoykova
Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis
Development, April 1, 2007; 134(7): 1311 - 1322.
[Abstract] [Full Text] [PDF]
J. R. McDearmid, M. Liao, and P. Drapeau
Glycine receptors regulate interneuron differentiation during spinal network development
PNAS, June 20, 2006; 103(25): 9679 - 9684.
[Abstract] [Full Text] [PDF]
J. S. Gal, Y. M. Morozov, A. E. Ayoub, M. Chatterjee, P. Rakic, and T. F. Haydar
Molecular and Morphological Heterogeneity of Neural Precursors in the Mouse Neocortical Proliferative Zones
J. Neurosci., January 18, 2006; 26(3): 1045 - 1056.
[Abstract] [Full Text] [PDF]
J.-C. Platel, S. Boisseau, A. Dupuis, J. Brocard, A. Poupard, M. Savasta, M. Villaz, and M. Albrieux
Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate
PNAS, December 27, 2005; 102(52): 19174 - 19179.
[Abstract] [Full Text] [PDF]
T. Tarui, T. Takahashi, R.S. Nowakowski, N.L. Hayes, P.G. Bhide, and V.S. Caviness
Overexpression of p27Kip1, Probability of Cell Cycle Exit, and Laminar Destination of Neocortical Neurons
Cereb Cortex, September 1, 2005; 15(9): 1343 - 1355.
[Abstract] [Full Text] [PDF]
J. M. Gohlke, W. C. Griffith, and E. M. Faustman
A Systems-Based Computational Model for Dose-Response Comparisons of Two Mode of Action Hypotheses for Ethanol-Induced Neurodevelopmental Toxicity
Toxicol. Sci., August 1, 2005; 86(2): 470 - 484.
[Abstract] [Full Text] [PDF]
W. J. Moody and M. M. Bosma
Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells
Physiol Rev, July 1, 2005; 85(3): 883 - 941.
[Abstract] [Full Text] [PDF]
C. Zimmer, M.-C. Tiveron, R. Bodmer, and H. Cremer
Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons
Cereb Cortex, December 1, 2004; 14(12): 1408 - 1420.
[Abstract] [Full Text] [PDF]
Z Xie, K. P. M Currie, and A. P Fox
Etomidate elevates intracellular calcium levels and promotes catecholamine secretion in bovine chromaffin cells
J. Physiol., November 1, 2004; 560(3): 677 - 690.
[Abstract] [Full Text] [PDF]
L. G. Costa, L. Steardo, and V. Cuomo
Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects
Pharmacol. Rev., March 1, 2004; 56(1): 103 - 147.
[Abstract] [Full Text] [PDF]
Z. Xie, K.P.M. Currie, A. L. Cahill, and A. P. Fox
Role of Cl- Co-Transporters in the Excitation Produced by GABAA Receptors in Juvenile Bovine Adrenal Chromaffin Cells
J Neurophysiol, December 1, 2003; 90(6): 3828 - 3837.
[Abstract] [Full Text] [PDF]
P. W. Land and A. P. Monaghan
Expression of the Transcription Factor, tailless, Is Required for Formation of Superficial Cortical Layers
Cereb Cortex, September 1, 2003; 13(9): 921 - 931.
[Abstract] [Full Text] [PDF]
V. Gallo and T. Haydar
GABA: Exciting Again in Its Own Right
J. Physiol., August 1, 2003; 550(3): 665 - 665.
[Full Text] [PDF]
D D Wang, D D Krueger, and A Bordey
GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation
J. Physiol., August 1, 2003; 550(3): 785 - 800.
[Abstract] [Full Text] [PDF]
J. Viti, A. Gulacsi, and L. Lillien
Wnt Regulation of Progenitor Maturation in the Cortex Depends on Shh or Fibroblast Growth Factor 2
J. Neurosci., July 2, 2003; 23(13): 5919 - 5927.
[Abstract] [Full Text] [PDF]
F. Barnabe-Heider and F. D. Miller
Endogenously Produced Neurotrophins Regulate Survival and Differentiation of Cortical Progenitors via Distinct Signaling Pathways
J. Neurosci., June 15, 2003; 23(12): 5149 - 5160.
[Abstract] [Full Text] [PDF]
T. Weissman, S. C. Noctor, B. K. Clinton, L. S. Honig, and A. R. Kriegstein
Neurogenic Radial Glial Cells in Reptile, Rodent and Human: from Mitosis to Migration
Cereb Cortex, June 1, 2003; 13(6): 550 - 559.
[Abstract] [Full Text] [PDF]
L. Nguyen, B. Malgrange, I. Breuskin, L. Bettendorff, G. Moonen, S. Belachew, and J.-M. Rigo
Autocrine/Paracrine Activation of the GABAA Receptor Inhibits the Proliferation of Neurogenic Polysialylated Neural Cell Adhesion Molecule-Positive (PSA-NCAM+) Precursor Cells from Postnatal Striatum
J. Neurosci., April 15, 2003; 23(8): 3278 - 3294.
[Abstract] [Full Text] [PDF]
H. L. Picken Bahrey and W. J. Moody
Early Development of Voltage-Gated Ion Currents and Firing Properties in Neurons of the Mouse Cerebral Cortex
J Neurophysiol, April 1, 2003; 89(4): 1761 - 1773.
[Abstract] [Full Text] [PDF]
N. Ohtani, T. Goto, C. Waeber, and P. G. Bhide
Dopamine Modulates Cell Cycle in the Lateral Ganglionic Eminence
J. Neurosci., April 1, 2003; 23(7): 2840 - 2850.
[Abstract] [Full Text] [PDF]
K. C. Luk, T. E. Kennedy, and A. F. Sadikot
Glutamate Promotes Proliferation of Striatal Neuronal Progenitors by an NMDA Receptor-Mediated Mechanism
J. Neurosci., March 15, 2003; 23(6): 2239 - 2250.
[Abstract] [Full Text] [PDF]
A. E. Csillik, E. Okuno, B. Csillik, E. Knyihar, and L. Vecsei
Expression of Kynurenine Aminotransferase in the Subplate of the Rat and Its Possible Role in the Regulation of Programmed Cell Death
Cereb Cortex, November 1, 2002; 12(11): 1193 - 1201.
[Abstract] [Full Text] [PDF]
R. Pearson, M. Catsicas, D. Becker, and P. Mobbs
Purinergic and Muscarinic Modulation of the Cell Cycle and Calcium Signaling in the Chick Retinal Ventricular Zone
J. Neurosci., September 1, 2002; 22(17): 7569 - 7579.
[Abstract] [Full Text] [PDF]
I. L. Hanganu, W. Kilb, and H. J. Luhmann
Functional Synaptic Projections onto Subplate Neurons in Neonatal Rat Somatosensory Cortex
J. Neurosci., August 15, 2002; 22(16): 7165 - 7176.
[Abstract] [Full Text] [PDF]
J.M. Soria and M. Valdeolmillos
Receptor-activated Calcium Signals in Tangentially Migrating Cortical Cells
Cereb Cortex, August 1, 2002; 12(8): 831 - 839.
[Abstract] [Full Text] [PDF]
H. Wichterle, D. H. Turnbull, S. Nery, G. Fishell, and A. Alvarez-Buylla
In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain
Development, October 1, 2001; 128(19): 3759 - 3771.
[Abstract] [Full Text] [PDF]
M. S. Lidow and Z.-M. Song
Effect of Cocaine on Cell Proliferation in the Cerebral Wall of Monkey Fetuses
Cereb Cortex, June 1, 2001; 11(6): 545 - 551.
[Abstract] [Full Text] [PDF]
V. Tarabykin, A. Stoykova, N. Usman, and P. Gruss
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression
Development, June 1, 2001; 128(11): 1983 - 1993.
[Abstract] [Full Text] [PDF]
D. Maric, Q.-Y. Liu, I. Maric, S. Chaudry, Y.-H. Chang, S. V. Smith, W. Sieghart, J.-M. Fritschy, and J. L. Barker
GABA Expression Dominates Neuronal Lineage Progression in the Embryonic Rat Neocortex and Facilitates Neurite Outgrowth via GABAA Autoreceptor/Cl{-} Channels
J. Neurosci., April 1, 2001; 21(7): 2343 - 2360.
[Abstract] [Full Text] [PDF]
C. Dehay, P. Savatier, V. Cortay, and H. Kennedy
Cell-Cycle Kinetics of Neocortical Precursors Are Influenced by Embryonic Thalamic Axons
J. Neurosci., January 1, 2001; 21(1): 201 - 214.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|