 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, August 1, 2000, 20(15):5775-5781
BDNF Protects the Neonatal Brain from Hypoxic-Ischemic Injury In Vivo via the ERK Pathway
Byung Hee Han1 and David M. Holtzman1, 2, 3 Departments of 1 Neurology and 2 Molecular Biology and Pharmacology and the 3 Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110
Neurotrophins activate several different intracellular signaling pathways that in some way exert neuroprotective effects. In vitro studies of sympathetic and cerebellar granule neurons have demonstrated that the survival effects of neurotrophins can be mediated via activation of the phosphatidylinositol 3-kinase (PI3-kinase) pathway. Neurotrophin-mediated protection of other neuronal types in vitro can be mediated via the extracellular signal-related protein kinase (ERK) pathway. Whether either of these pathways contributes to the neuroprotective effects of neurotrophins in the brain in vivo has not been determined. Brain-derived neurotrophic factor (BDNF) is markedly neuroprotective against neonatal hypoxic-ischemic (H-I) brain injury in vivo. We assessed the role of the ERK and PI3-kinase pathways in neonatal H-I brain injury in the presence and absence of BDNF. Intracerebroventricular administration of BDNF to postnatal day 7 rats resulted in phosphorylation of ERK1/2 and the PI3-kinase substrate AKT within minutes. Effects were greater on ERK activation and occurred in neurons. Pharmacological inhibition of ERK, but not the PI3-kinase pathway, inhibited the ability of BDNF to block H-I-induced caspase-3 activation and tissue loss. These findings suggest that neuronal ERK activation in the neonatal brain mediates neuroprotection against H-I brain injury, a model of cerebral palsy.
Key words: cerebral palsy; neurotrophin; MAP kinase; PI3-kinase; ischemia; apoptosis
Copyright © 2000 Society for Neuroscience 0270-6474/00/20155775-07$05.00/0
This article has been cited by other articles:
M. F. Wendland, J. Faustino, T. West, C. Manabat, D. M. Holtzman, and Z. S. Vexler
Early Diffusion-Weighted MRI as a Predictor of Caspase-3 Activation After Hypoxic-Ischemic Insult in Neonatal Rodents
Stroke, June 1, 2008; 39(6): 1862 - 1868.
[Abstract] [Full Text] [PDF]
F. Zhang, S. Wang, A. P. Signore, and J. Chen
Neuroprotective Effects of Leptin Against Ischemic Injury Induced by Oxygen-Glucose Deprivation and Transient Cerebral Ischemia
Stroke, August 1, 2007; 38(8): 2329 - 2336.
[Abstract] [Full Text] [PDF]
A. Woronowicz, S. R. Amith, V. W Davis, P. Jayanth, K. De Vusser, W. Laroy, R. Contreras, S. O Meakin, and M. R Szewczuk
Trypanosome trans-sialidase mediates neuroprotection against oxidative stress, serum/glucose deprivation, and hypoxia-induced neurite retraction in Trk-expressing PC12 cells
Glycobiology, July 1, 2007; 17(7): 725 - 734.
[Abstract] [Full Text] [PDF]
W.-R. Schabitz, T. Steigleder, C. M. Cooper-Kuhn, S. Schwab, C. Sommer, A. Schneider, and H. G. Kuhn
Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis
Stroke, July 1, 2007; 38(7): 2165 - 2172.
[Abstract] [Full Text] [PDF]
H. Taniguchi, I. Mohri, H. Okabe-Arahori, K. Aritake, K. Wada, T. Kanekiyo, S. Narumiya, M. Nakayama, K. Ozono, Y. Urade, et al.
Prostaglandin D2 Protects Neonatal Mouse Brain from Hypoxic Ischemic Injury
J. Neurosci., April 18, 2007; 27(16): 4303 - 4312.
[Abstract] [Full Text] [PDF]
U. Kilic, E. Kilic, A. Jarve, Z. Guo, A. Spudich, K. Bieber, U. Barzena, C. L. Bassetti, H. H. Marti, and D. M. Hermann
Human Vascular Endothelial Growth Factor Protects Axotomized Retinal Ganglion Cells In Vivo by Activating ERK-1/2 and Akt Pathways
J. Neurosci., November 29, 2006; 26(48): 12439 - 12446.
[Abstract] [Full Text] [PDF]
E. M. Szego, K. Barabas, J. Balog, N. Szilagyi, K. S. Korach, G. Juhasz, and I. M. Abraham
Estrogen Induces Estrogen Receptor {alpha}-Dependent cAMP Response Element-Binding Protein Phosphorylation via Mitogen Activated Protein Kinase Pathway in Basal Forebrain Cholinergic Neurons In Vivo
J. Neurosci., April 12, 2006; 26(15): 4104 - 4110.
[Abstract] [Full Text] [PDF]
L. Wei, B. H. Han, Y. Li, C. L. Keogh, D. M. Holtzman, and S. P. Yu
Cell Death Mechanism and Protective Effect of Erythropoietin after Focal Ischemia in the Whisker-Barrel Cortex of Neonatal Rats
J. Pharmacol. Exp. Ther., April 1, 2006; 317(1): 109 - 116.
[Abstract] [Full Text] [PDF]
ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor, phosphorylated extracellular signal-regulated kinase, and caspase3 after spinal cord ischemia in rabbits.
J. Thorac. Cardiovasc. Surg., March 1, 2006; 131(3): 644 - 650.
C.-C. Huang, P.-H. Chou, C.-H. Yang, and K.-S. Hsu
Neonatal isolation accelerates the developmental switch in the signalling cascades for long-term potentiation induction
J. Physiol., December 15, 2005; 569(3): 789 - 799.
[Abstract] [Full Text] [PDF]
K. G. Brywe, A.-L. Leverin, M. Gustavsson, C. Mallard, R. Granata, S. Destefanis, M. Volante, H. Hagberg, E. Ghigo, and J. Isgaard
Growth Hormone-Releasing Peptide Hexarelin Reduces Neonatal Brain Injury and Alters Akt/Glycogen Synthase Kinase-3{beta} Phosphorylation
Endocrinology, November 1, 2005; 146(11): 4665 - 4672.
[Abstract] [Full Text] [PDF]
M. Alonso, P. Bekinschtein, M. Cammarota, M. R.M. Vianna, I. Izquierdo, and J. H. Medina
Endogenous BDNF is required for long-term memory formation in the rat parietal cortex
Learn. Mem., September 1, 2005; 12(5): 504 - 510.
[Abstract] [Full Text] [PDF]
N. Miwa and D. R. Storm
Odorant-Induced Activation of Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase in the Olfactory Bulb Promotes Survival of Newly Formed Granule Cells
J. Neurosci., June 1, 2005; 25(22): 5404 - 5412.
[Abstract] [Full Text] [PDF]
I. Husson, C.-M. Rangon, V. Lelievre, A.-P. Bemelmans, P. Sachs, J. Mallet, B. E. Kosofsky, and P. Gressens
BDNF-induced White Matter Neuroprotection and Stage-dependent Neuronal Survival Following a Neonatal Excitotoxic Challenge
Cereb Cortex, March 1, 2005; 15(3): 250 - 261.
[Abstract] [Full Text] [PDF]
Veeranna, T. Kaji, B. Boland, T. Odrljin, P. Mohan, B. S. Basavarajappa, C. Peterhoff, A. Cataldo, A. Rudnicki, N. Amin, et al.
Calpain Mediates Calcium-Induced Activation of the Erk1,2 MAPK Pathway and Cytoskeletal Phosphorylation in Neurons: Relevance to Alzheimer's Disease
Am. J. Pathol., September 1, 2004; 165(3): 795 - 805.
[Abstract] [Full Text] [PDF]
S. Naska, M. C. Cenni, E. Menna, and L. Maffei
ERK signaling is required for eye-specific retino-geniculate segregation
Development, August 1, 2004; 131(15): 3559 - 3570.
[Abstract] [Full Text] [PDF]
J. Kipnis, H. Cohen, M. Cardon, Y. Ziv, and M. Schwartz
T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
PNAS, May 25, 2004; 101(21): 8180 - 8185.
[Abstract] [Full Text] [PDF]
M. Ueda, R. Fujita, T. Koji, and H. Ueda
The Cognition-Enhancer Nefiracetam Inhibits Both Necrosis and Apoptosis in Retinal Ischemic Models in Vitro and in Vivo
J. Pharmacol. Exp. Ther., April 1, 2004; 309(1): 200 - 207.
[Abstract] [Full Text]
D. J. Levinthal and D. B. DeFranco
Transient Phosphatidylinositol 3-Kinase Inhibition Protects Immature Primary Cortical Neurons from Oxidative Toxicity via Suppression of Extracellular Signal-regulated Kinase Activation
J. Biol. Chem., March 19, 2004; 279(12): 11206 - 11213.
[Abstract] [Full Text] [PDF]
L. Cancedda, E. Putignano, S. Impey, L. Maffei, G. M. Ratto, and T. Pizzorusso
Patterned Vision Causes CRE-Mediated Gene Expression in the Visual Cortex through PKA and ERK
J. Neurosci., August 6, 2003; 23(18): 7012 - 7020.
[Abstract] [Full Text] [PDF]
J. K. Wong, H. H. Le, A. Zsarnovszky, and S. M. Belcher
Estrogens and ICI182,780 (Faslodex) Modulate Mitosis and Cell Death in Immature Cerebellar Neurons via Rapid Activation of p44/p42 Mitogen-Activated Protein Kinase
J. Neurosci., June 15, 2003; 23(12): 4984 - 4995.
[Abstract] [Full Text] [PDF]
D. L. Hynds, M. L. Spencer, D. A. Andres, and D. M. Snow
Rit promotes MEK-independent neurite branching in human neuroblastoma cells
J. Cell Sci., May 15, 2003; 116(10): 1925 - 1935.
[Abstract] [Full Text] [PDF]
F. M. Benes, J. Walsh, S. Bhattacharyya, A. Sheth, and S. Berretta
DNA Fragmentation Decreased in Schizophrenia but Not Bipolar Disorder
Arch Gen Psychiatry, April 1, 2003; 60(4): 359 - 364.
[Abstract] [Full Text] [PDF]
S. Subramaniam, J. Strelau, and K. Unsicker
Growth Differentiation Factor-15 Prevents Low Potassium-induced Cell Death of Cerebellar Granule Neurons by Differential Regulation of Akt and ERK Pathways
J. Biol. Chem., March 7, 2003; 278(11): 8904 - 8912.
[Abstract] [Full Text] [PDF]
X. Wang, H. Wang, L. Xu, D. J. Rozanski, T. Sugawara, P. H. Chan, J. M. Trzaskos, and G. Z. Feuerstein
Significant Neuroprotection against Ischemic Brain Injury by Inhibition of the MEK1 Protein Kinase in Mice: Exploration of Potential Mechanism Associated with Apoptosis
J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 172 - 178.
[Abstract] [Full Text] [PDF]
W. Fu, C. Lu, and M. P. Mattson
Telomerase Mediates the Cell Survival-Promoting Actions of Brain-Derived Neurotrophic Factor and Secreted Amyloid Precursor Protein in Developing Hippocampal Neurons
J. Neurosci., December 15, 2002; 22(24): 10710 - 10719.
[Abstract] [Full Text] [PDF]
M. Hetman, S.-L. Hsuan, A. Habas, M. J. Higgins, and Z. Xia
ERK1/2 Antagonizes Glycogen Synthase Kinase-3beta -induced Apoptosis in Cortical Neurons
J. Biol. Chem., December 13, 2002; 277(51): 49577 - 49584.
[Abstract] [Full Text] [PDF]
J. Jaboin, C. J. Kim, D. R. Kaplan, and C. J. Thiele
Brain-derived Neurotrophic Factor Activation of TrkB Protects Neuroblastoma Cells from Chemotherapy-induced Apoptosis via Phosphatidylinositol 3'-Kinase Pathway
Cancer Res., November 15, 2002; 62(22): 6756 - 6763.
[Abstract] [Full Text] [PDF]
P. Bittigau, M. Sifringer, K. Genz, E. Reith, D. Pospischil, S. Govindarajalu, M. Dzietko, S. Pesditschek, I. Mai, K. Dikranian, et al.
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain
PNAS, November 12, 2002; 99(23): 15089 - 15094.
[Abstract] [Full Text] [PDF]
K. M. Dhandapani and D. W. Brann
Protective Effects of Estrogen and Selective Estrogen Receptor Modulators in the Brain
Biol Reprod, November 1, 2002; 67(5): 1379 - 1385.
[Abstract] [Full Text] [PDF]
B. H. Han, D. Xu, J. Choi, Y. Han, S. Xanthoudakis, S. Roy, J. Tam, J. Vaillancourt, J. Colucci, R. Siman, et al.
Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury
J. Biol. Chem., August 9, 2002; 277(33): 30128 - 30136.
[Abstract] [Full Text] [PDF]
A. Wick, W. Wick, J. Waltenberger, M. Weller, J. Dichgans, and J. B. Schulz
Neuroprotection by Hypoxic Preconditioning Requires Sequential Activation of Vascular Endothelial Growth Factor Receptor and Akt
J. Neurosci., August 1, 2002; 22(15): 6401 - 6407.
[Abstract] [Full Text] [PDF]
M. V. Johnston, W. Nakajima, and H. Hagberg
Mechanisms of Hypoxic Neurodegeneration in the Developing Brain
Neuroscientist, June 1, 2002; 8(3): 212 - 220.
[Abstract] [PDF]
Y. Zhu, G.-Y. Yang, B. Ahlemeyer, L. Pang, X.-M. Che, C. Culmsee, S. Klumpp, and J. Krieglstein
Transforming Growth Factor-beta 1 Increases Bad Phosphorylation and Protects Neurons Against Damage
J. Neurosci., May 15, 2002; 22(10): 3898 - 3909.
[Abstract] [Full Text] [PDF]
L. Cheng, P. Sapieha, P. Kittlerova, W. W. Hauswirth, and A. Di Polo
TrkB Gene Transfer Protects Retinal Ganglion Cells from Axotomy-Induced Death In Vivo
J. Neurosci., May 15, 2002; 22(10): 3977 - 3986.
[Abstract] [Full Text] [PDF]
Y. Shirayama, A. C.-H. Chen, S. Nakagawa, D. S. Russell, and R. S. Duman
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
J. Neurosci., April 15, 2002; 22(8): 3251 - 3261.
[Abstract] [Full Text] [PDF]
M. Stanciu and D. B. DeFranco
Prolonged Nuclear Retention of Activated Extracellular Signal-regulated Protein Kinase Promotes Cell Death Generated by Oxidative Toxicity or Proteasome Inhibition in a Neuronal Cell Line
J. Biol. Chem., February 1, 2002; 277(6): 4010 - 4017.
[Abstract] [Full Text] [PDF]
R.-R. Ji, K. Befort, G. J. Brenner, and C. J. Woolf
ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity
J. Neurosci., January 15, 2002; 22(2): 478 - 485.
[Abstract] [Full Text] [PDF]
N. Kinkl, J. Sahel, and D. Hicks
Alternate FGF2-ERK1/2 Signaling Pathways in Retinal Photoreceptor and Glial Cells in Vitro
J. Biol. Chem., November 16, 2001; 276(47): 43871 - 43878.
[Abstract] [Full Text] [PDF]
P. Calabresi, E. Saulle, G. A. Marfia, D. Centonze, R. Mulloy, B. Picconi, R. A. Hipskind, F. Conquet, and G. Bernardi
Activation of Metabotropic Glutamate Receptor Subtype 1/Protein Kinase C/Mitogen-Activated Protein Kinase Pathway Is Required for Postischemic Long-Term Potentiation in the Striatum
Mol. Pharmacol., October 1, 2001; 60(4): 808 - 815.
[Abstract] [Full Text] [PDF]
M. P. Lafuente, M. P. Villegas-Perez, P. Sobrado-Calvo, A. Garcia-Aviles, J. Miralles de Imperial, and M. Vidal-Sanz
Neuroprotective Effects of {alpha}2-Selective Adrenergic Agonists against Ischemia-Induced Retinal Ganglion Cell Death
Invest. Ophthalmol. Vis. Sci., August 1, 2001; 42(9): 2074 - 2084.
[Abstract] [Full Text] [PDF]
B. A. Ballif and J. Blenis
Molecular Mechanisms Mediating Mammalian Mitogen-activated Protein Kinase (MAPK) Kinase (MEK)-MAPK Cell Survival Signals
Cell Growth Differ., August 1, 2001; 12(8): 397 - 408.
[Full Text] [PDF]
K. Nandagopal, T. M. Dawson, and V. L. Dawson
Critical Role for Nitric Oxide Signaling in Cardiac and Neuronal Ischemic Preconditioning and Tolerance
J. Pharmacol. Exp. Ther., April 12, 2001; 297(2): 474 - 478.
[Abstract] [Full Text]
D. B. Wells, P. J. Tighe, K. G. Wooldridge, K. Robinson, and D. A. A. Ala' Aldeen
Differential Gene Expression during Meningeal-Meningococcal Interaction: Evidence for Self-Defense and Early Release of Cytokines and Chemokines
Infect. Immun., April 1, 2001; 69(4): 2718 - 2722.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|