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The Journal of Neuroscience, August 15, 2000, 20(16):6159-6165
Dissociable Neural Responses in Human Reward Systems
Rebecca Elliott1, Karl J. Friston1, and Raymond J. Dolan1, 2 1 Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom, and 2 Royal Free Hospital School of Medicine, London, NW3 2PF, United Kingdom
Reward is one of the most important influences shaping behavior. Single-unit recording and lesion studies in experimental animals have implicated a number of regions in response to reinforcing stimuli, in particular regions of the extended limbic system and the ventral striatum. In this experiment, functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts. Nine healthy volunteers were scanned using functional magnetic resonance imaging during the performance of a gambling task with financial rewards and penalties. We demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties. Furthermore, we show that neural responses in globus pallidus, thalamus, and subgenual cingulate were specific to high reward levels occurring in the context of increasing reward. Responses to both reward level in the context of increasing reward and penalty level in the context of increasing penalty were seen in caudate, insula, and ventral prefrontal cortex. These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced.
Key words: ventral striatum; hippocampus; orbitofrontal cortex; caudate; insula; gambling; decision-making
Copyright © 2000 Society for Neuroscience 0270-6474/00/20166159-07$05.00/0
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