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The Journal of Neuroscience, August 15, 2000, 20(16):6166-6172

Relationship among Discharges of Neighboring Neurons in the Rat Prefrontal Cortex During Spatial Working Memory Tasks

Min Whan Jung^{1, 3}, Yulin Qin⁵, Daeyeol Lee⁶, and Inhee Mook-Jung^{2, 4}

¹ Neuroscience Laboratory, Institute for Medical Sciences, ² Brain Disease Research Center, ³ Department of Physiology, and ⁴ Department of Anatomy, Ajou University School of Medicine, Suwon 442-721, Korea, ⁵ Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas 77030, and ⁶ Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, New York 14627

The relationship among discharges of neurons that were recorded simultaneously with tetrodes in the rat medial prefrontal cortex was analyzed. Spatial working memory tasks were divided into several distinct stages based on the behavioral correlates of individual neurons, and interneuronal correlation of signal (mean discharge rate at each stage) and noise (trial-to-trial deviation from the signal) was calculated. Behavioral correlates of neighboring neurons were quite heterogeneous and, accordingly, average signal correlation was relatively low (~0.16). Noise correlation was even lower (~0.06), but neuronal noise was more correlated among the neurons with similar signals. Spikes underlying the signal and noise correlation among the prefrontal cortical neurons were loosely synchronized over a few hundred milliseconds. These results suggest that neighboring prefrontal cortical neurons process largely independent information and have weakly correlated noise and that precisely synchronized spikes play a relatively minor role in producing the correlated signal and noise among these neurons.

Key words: single unit; signal correlation; noise correlation; cortical column; adjacent neurons; prefrontal cortex; synchronous firing; tetrode

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Copyright © 2000 Society for Neuroscience  0270-6474/00/20166166-07$05.00/0

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